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Structure of 286440-92-4

Chemical Structure| 286440-92-4

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Product Details of [ 286440-92-4 ]

CAS No. :286440-92-4
Formula : C8H8F2O
M.W : 158.15
SMILES Code : FC1=CC=C(CCO)C=C1F
MDL No. :MFCD00143061
Boiling Point : No data available
InChI Key :LQIZHIYYOQHWNF-UHFFFAOYSA-N
Pubchem ID :2758313

Safety of [ 286440-92-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 286440-92-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 286440-92-4 ]

[ 286440-92-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 286440-92-4 ]
  • [ 175018-77-6 ]
YieldReaction ConditionsOperation in experiment
With sodium bicarbonate; sulfuric acid; hydrogen bromide; Preparation of 3,4-difluorophenethylbromide 17.59 g (111 mmol) of 2-(3,4-difluorophenyl)ethanol, 16 ml (137 mmol) of hydrogen bromide, 6.8 ml (234 mmol) of conc. sulfuric acid were added in the order, and the mixture was heated under reflux for 3 hrs. The reaction mixture was poured onto an ice-bath, an organic layer and an aqueous layer were separated, the aqueous layer was extracted with ether, the extract combined with the organic layer was washed with a saturated aqueous solution of sodium hydrogen carbonate, and dried over anhydrous magnesium sulfate. The solvent was distilled off, the solution condensed and purified by vacuum distillation to obtain 21.96 g (bp 68-70 C./2-4 Torr.) of oily product. The oily product was purified by column chromatography (elution solvent: hexane:ethyl acetate=3:1), the elude was further purified by vacuum distillation to obtain 19.79 g of the title compound (81%, bp 73-75 C./4 Torr.) as oily product.
With sulfuric acid; hydrogen bromide; In acetic acid; at 100.0℃; for 4.0h; A mixture of 2-(3,4-difluorophenyl)ethanol (5 g, 0.032 mol; see step (iii) above), HBr in acetic acid (51.84 mL of 49%, 0.64 mol) and 5 mL of sulfuric acid was stirred at 1000C for 4 h. The reaction mixture was poured onto ice and extracted with diethylether. The organic layer was washed with NaHCO3 and water and then dried over sodium sulfate. Solvent evaporation under reduced pressure, followed <n="90"/>by purification (three times) over silica gel (using petroleum ether as eluent), afforded 1.8 g of the title compound as a liquid.
 

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