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Chemical Structure| 2832-19-1 Chemical Structure| 2832-19-1
Chemical Structure| 2832-19-1

2-Chloro-N-(hydroxymethyl)acetamide

CAS No.: 2832-19-1

4.5 *For Research Use Only !

Cat. No.: A824058 Purity: 97%

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Product Details of 2-Chloro-N-(hydroxymethyl)acetamide

CAS No. :2832-19-1
Formula : C3H6ClNO2
M.W : 123.54
SMILES Code : O=C(NCO)CCl
MDL No. :MFCD00021961
InChI Key :TXNSZCSYBXHETP-UHFFFAOYSA-N
Pubchem ID :62466

Safety of 2-Chloro-N-(hydroxymethyl)acetamide

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of 2-Chloro-N-(hydroxymethyl)acetamide

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2832-19-1 ]

[ 2832-19-1 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 2832-19-1 ]
  • [ 827-99-6 ]
  • [ 562080-94-8 ]
YieldReaction ConditionsOperation in experiment
33.8% In concentrated sulfuric acid; acetic acid; EXAMPLE 73 2-Chloro-N-(2-hydroxy-4-trifluoromethoxy-benzyl)-acetamide <strong>[827-99-6]3-(Trifluoromethoxy)phenol</strong> (4.827 g, 27 mmol) was dissolved in glacial acetic acid (20 mL). The mixture was cooled in an ice bath between 14-17° C. and concentrated sulfuric acid (2 mL) was slowly added keeping the temperature below 20° C. The mixture was cooled below 10° C. and N-hydroxymethyl-2-chloroacetamide (3.52 g, 28.5 mmol) was added. The mixture was warmed slowly to room temperature and stirred overnight. The mixture was then poured slowly into ice (200 mL) and the pH was adjusted to ~4-5 with KOH pellets, keeping the temperature below 5° C. The reaction mixture was warmed to room temperature and extracted twice with ethyl acetate (150 mL). The organic layer was collected and washed with NaHCO3 (sat., 30 mL). The organic layer was dried over MgSO4, filtered and the solvent removed to dryness. The mixture was purified by column chromatography (SiO2, 700 mL) using an eluent of hexane/ethyl acetate (10/2). Recovery: 2.42 g (33.8percent yield). 1H NMR (DMSO) delta=10.23 (1H, s), 8.56 (1H, st), 7.16-7.14 (1H, sd), 6.71-6.70 (2H, br), 4.18-4.17 (2H, d), 4.08 (2H, s).
 

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