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Chemical Structure| 280110-63-6 Chemical Structure| 280110-63-6

Structure of 280110-63-6

Chemical Structure| 280110-63-6

tert-Butyl 4-(N-hydroxycarbamimidoyl)piperidine-1-carboxylate

CAS No.: 280110-63-6

4.5 *For Research Use Only !

Cat. No.: A282275 Purity: 97%

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Product Details of [ 280110-63-6 ]

CAS No. :280110-63-6
Formula : C11H21N3O3
M.W : 243.30
SMILES Code : O=C(OC(C)(C)C)N1CCC(C(=N)NO)CC1
MDL No. :MFCD09951950

Safety of [ 280110-63-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 280110-63-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 280110-63-6 ]

[ 280110-63-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 280110-63-6 ]
  • [ 2991-28-8 ]
  • [ 1205637-32-6 ]
YieldReaction ConditionsOperation in experiment
Preparation Example 27To a solution of <strong>[2991-28-8]2,5-difluorobenzoic acid</strong> (1.95 g) in THF (40 mL) were added oxalyl chloride (1.5 mL) and a catalytic amount of DMF, followed by stirring at room temperature for 1 hour.The reaction liquid was concentrated under reduced pressure, and to the residue was added THF (40 mL).Under ice-cooling, tert-butyl 4-[amino(hydroxyimino)methyl]piperidine-1-carboxylate (2.5 g) and triethylamine (3.0 mL) were added thereto, followed by stirring at room temperature for 2 hours.To the reaction liquid were added ethyl acetate and water, and the organic phase was separated.The organic phase was washed with water and saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure.To a solution of the residue in THF (20 mL) was added a 1 M tetrabutylammonium fluoride/THF solution (10.3 mL), followed by stirring at 50°C for 30 minutes.The reaction liquid was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform).To the purified product was added 4 M hydrogen chloride/dioxane (40 mL), followed by stirring at room temperature for 2 hours.The reaction liquid was concentrated under reduced pressure, then to the residue was added THF, and the resulting solid was collected by filtration.The solid was washed with THF and ethyl acetate in this order, and dried under reduced pressure to obtain 4-[5-(2,5-difluorophenyl)-1,2,4-oxadiazol-3-yl]piperidine hydrochloride (2.58 g).
 

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