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Structure of 28004-62-8

Chemical Structure| 28004-62-8

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Product Details of [ 28004-62-8 ]

CAS No. :28004-62-8
Formula : C8H6ClN3S
M.W : 211.67
SMILES Code : NC1=NN=C(C2=CC=C(Cl)C=C2)S1
MDL No. :MFCD00980966
InChI Key :OAVULPOOAHQYDZ-UHFFFAOYSA-N
Pubchem ID :668392

Safety of [ 28004-62-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 28004-62-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 28004-62-8 ]

[ 28004-62-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 14437-03-7 ]
  • [ 28004-62-8 ]
  • [ 13483-94-8 ]
  • 2
  • [ 60456-77-1 ]
  • [ 109-77-3 ]
  • [ 28004-62-8 ]
  • 5-amino-2-(4-chlorophenyl)-7-(furan-2-yl)-7H-(1,3,4)thiadiazolo(3,2-a)pyrimidine-6-carbonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% With sodium hydroxide; In ethanol; at 80℃; for 1.3h;Sonication; Green chemistry; General procedure: A 25 mL a beaker was charged with a mixture of an 5-(4-chlorophenyl)-1,3,4-thiadiazol-2 amine (0.01 mol) (1), malononitrile (0.01 mol) (2), suitable aldehyde (0.01 mol) (3) inethanol (10-12 mL) and the catalyst NaOH (20% mmol) and the reaction mixture was kept insidean Ultrasonicator acoustic chamber at 80 C at 20%. After completion of the reaction (monitored byTLC), the mixture was poured into ice cold water. The product obtained, was filtered and dried. Thecorresponding product was obtained in high purity after recrystallization of the crude product fromethanol. The authenticity of compounds was established by 1H-NMR, 13C-NMR, IR and HRMS.
 

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Related Parent Nucleus of
[ 28004-62-8 ]

Thiadiazoles

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