There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Structure of 4-trans-Hydroxycyclohexylamine
CAS No.: 27489-62-9
*Storage: {[sel_prStorage]}
*Shipping: {[sel_prShipping]}
The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Synonyms: trans-4-Aminocyclohexan-1-ol
4.5
*For Research Use Only !
Change View
Size | Price | VIP Price | US Stock |
Global Stock |
In Stock | ||
{[ item.pr_size ]} |
Inquiry
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.discount_usd) ]} {[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} |
Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]} | Inquiry {[ item.pr_usastock ]} In Stock Inquiry - | {[ item.pr_chinastock ]} {[ item.pr_remark ]} In Stock 1-2 weeks - Inquiry - | Login | - + | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
1-2weeks
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price, item.pr_usd) ]}
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
In Stock
- +
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 27489-62-9 |
Formula : | C6H13NO |
M.W : | 115.17 |
SMILES Code : | O[C@H]1CC[C@H](N)CC1 |
Synonyms : |
trans-4-Aminocyclohexan-1-ol
|
MDL No. : | MFCD00067698 |
GHS Pictogram: |
![]() |
Signal Word: | Danger |
Hazard Statements: | H314 |
Precautionary Statements: | P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P260-P264-P280-P305+P351+P338-P405-P501 |
Class: | 8 |
UN#: | 3259 |
Packing Group: | Ⅲ |
Num. heavy atoms | 8 |
Num. arom. heavy atoms | 0 |
Fraction Csp3 | 1.0 |
Num. rotatable bonds | 0 |
Num. H-bond acceptors | 2.0 |
Num. H-bond donors | 2.0 |
Molar Refractivity | 32.71 |
TPSA ? Topological Polar Surface Area: Calculated from |
46.25 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
1.41 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
-0.06 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
0.25 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
0.21 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
0.39 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
0.44 |
Log S (ESOL):? ESOL: Topological method implemented from |
-0.52 |
Solubility | 35.1 mg/ml ; 0.305 mol/l |
Class? Solubility class: Log S scale |
Very soluble |
Log S (Ali)? Ali: Topological method implemented from |
-0.46 |
Solubility | 39.9 mg/ml ; 0.347 mol/l |
Class? Solubility class: Log S scale |
Very soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-0.1 |
Solubility | 92.3 mg/ml ; 0.802 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
No |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-7.05 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
1.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.91 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With potassium carbonate; In water monomer; at 20℃; for 0.5h; | K2CO3 (10.50 g, 75.97 mmol) was added to a solution of 190 (5.00 g, 43.41 mmol) in H2O(50 mL). N-(ethoxycarbonyl)phthalimide (10.24 g, 49.92 mmol) was added under stirring andthe reaction mixture was stirred for 30 min at room temperature. The resulting precipitate wasfiltered off and washed with H2O (50 mL). Removal of the residual solvent in vacuo affordedthe product as a beige solid (4.94 mg, 98%, Rf = 0.2 in EtOAc/PE 1/3), mp: 183-185 C (Lit.5mp: 177-178 C). 1H NMR (400 MHz, DMSO-d6): δ (ppm) 7.85 - 7.80 (m, 4H), 4.64 (d, J =4.3 Hz, 1H), 3.99 - 3.91 (m, 1H), 3.49 - 3.41 (m, 1H), 2.19 - 2.08 (m, 2H), 1.93 - 1.90 (m,2H), 1.69 - 1.66 (m, 2H), 1.32 - 1.21 (m, 2H). 13C NMR (100 MHz, DMSO-d6): δ (ppm) 168.30,134.80, 131.90, 123.40, 68.50, 49.90, 35.10, 27.80. HRMS (ESI-MS): m/z [M+H+] calculatedfor C14H16NO3+: 246.1125, found 246.1126; C14H15NO3 (245.28). |
44% | With potassium carbonate; In water monomer; at 0 - 20℃; | A7 (5759mg, 50mmol) and N-ethoxycarbonylphthalimide (B1, 10960mg, 50mmol) were placed in a reaction flask, 110mL of water was added, the temperature was lowered to 0C, and K2CO3 (13820mg, 100mmol) was added in batches , returned to room temperature, and stirred overnight. Filtration, and the filter cake was washed with water (30 mL×3). The solid obtained by filtration was dissolved in ethanol (190 mL), water (380 mL) was added, the solid was left to stand for 1 h, the solid was precipitated, filtered, and the filter cake was washed with ethanol/water (1:2) mixed solvent (20 mL×3), and dried at room temperature overnight. , and then dried under reduced pressure at 45 C. for 1 h to obtain B2 (white solid, 5371 mg, yield 44%). |
With triethylamine; In tetrahydrofuran; for 18h;Heating / reflux; | Step 1: trans-2-(4-Hydroxy-cyclohexyl)-isoindole-1,3-dione A mixture of 31 grams of trans-4-aminocyclohexanol, 550 mL of anhydrous THF, 45 mL of triethylamine and 53 g of N-carboethoxy-phthalimide was heated to reflux for 18 h, cooled, and diluted with 1500 mL of ethyl acetate. The solution was washed with 250 mL of 10% HCl, 100 mL of saturated sodium bicarbonate then dried over magnesium sulfate. Concentration under reduced pressure gave 66 g of product as a white crystalline solid contaminated with ethyl carbamate. This material was sufficiently pure for the next step, although it could be recrystallized from boiling ethyl acetate-hexane. 1H NMR (400 MHz, CDCl3) 7.8 (m, 2H), 7.7 (m, 2H), 4.15 (m, 1H), 3.7 (m, 1H), 2.3 (dd, 2H), 2.1 (d, 2H), 1.78 (d, 2H), 1.4 (dd, 2H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
79% | With pyridinium p-toluenesulfonate; In N,N-dimethyl-formamide; toluene; for 15 - 17h;Heating / reflux;Product distribution / selectivity; | A) SOOgms (2.608mole) of Trans-4-aminocyclohexanol was dissolve in 1500mlDimethyl formamide and 1500ml of Toluene. Add 386gms(2.608mole) of Phthalicanhydride and 3gm(0.012mole) pyridinium p-toluene sulphonate. The reaction mixtureis refluxed and remove water continuously from water separator, maintain this conditionfor 15-17 hrs. Evaporate solvent under reduced pressure. Add chloroform (3000ml).Wash organic part with 1000ml of 5%NaHCO3, then wash with 1000ml of brine solution.After concentration of reaction mass, crystallize residue in Isopropyl alcohol.YIELD :503gms(79%)PURITY: 99.66% |
77% | With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene; at 130 - 135℃; for 10h;Heating / reflux;Product distribution / selectivity; | (C) 25gms (0.2123mole) Trans-4-aminocyclohexanol was dissolved in 125ml of tolueneand 125ml of DMF. Add 32.17gm(0.2123mole) phthalic anhydride and 0.25gm (0.0066mole ) of p-toluene sulphonic acid. Reflux mass at 130-135C for lOhrs. Removecontinuously water from water separator. Cool mass to 40C.remove solvent underreduced pressure. Dissolve mass in 250ml chloroform, washed chloroform layer with5%NaHCO3 solution and brine solution. Evaporate chloroform and residue wascrystallizing in isopropyl alcohol.YIELD: 41gms(77%) |
71% | With pyridinium p-toluenesulfonate; In cyclohexane; N,N-dimethyl-formamide; at 90 - 95℃; for 19h;Heating / reflux;Product distribution / selectivity; | B) 25gms(0.2123mole) Trans-4-aminocyclohexanol was dissolve in 100ml cyclohexaneand 100ml DMF. Add 128.6gm(0.8689mole) phthalic anhydride and 0.25gm(0.001mole)pyridinium p-toluene sulphonate. Reflux mass at 90-95C for 19 hrs. Removecontinuously water from water separator. Cool mass to 40C, remove solvent underreduced pressure. Dissolve mass in 250ml chloroform, washed chloroform layer with5%NaHCC>3 solution and brine solution. Evaporate chloroform and residue wascrystallizing in isopropyl alcohol.YIELD: 38ems(71%) |
69.4% | With Pyridine hydrobromide; In N,N-dimethyl-formamide; toluene; at 130 - 135℃; for 15 - 17h;Heating / reflux;Product distribution / selectivity; | (D) 25gms(0.2123mole) Trans-4-aminocyclohexanol was dissolve in 125ml of tolueneand 125ml of DMF. Add 32.17gm(0.2123mole) phthalic anhydride and 0.25gm(0.0074mole) of pyridine hydrobromide. Reflux mass at 130-135C for 15-17 hrs. Removecontinuously water from water separator. Cool mass to 40C.remove solvent underreduced pressure. Dissolve mass in 250ml chloroform., washed chloroform layer with5%NaHCO3 solution and brine solution. Evaporate chloroform and residue wascrystallizing hi isopropyl alcohol.YIELD: 37gms(69.4%) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With NaH; In N,N-dimethyl-formamide; mineral oil; | Example 57A 4-(4-trans-aminocyclohexyloxy)-benzoic acid tert-butyl ester To a stirred solution of trans-4-aminocyclohexanol (345 mg, 3 mmol) in DMF (9 mL) at 0 C. was added 60% NaH in mineral oil (360 mg, 9 mmol). The reaction mixture was stirred at 0 C. for 1/2 hour and then <strong>[58656-98-7]ter<strong>[58656-98-7]t-butyl 4-fluorobenzoate</strong></strong> (706 mg, 3.6 mmol) was added. It was heated to 60 C. for 2 hours and stirred for 12 hours at room temperature. The reaction mixture was diluted with ethyl acetate and washed with water (3 times) and brine. The organic layer was dried (sodium sulfate), filtered, and concentrated under reduced pressure to provide the titled compound. MS (DCI) m/z 292 (M+H)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With NaH; In N,N-dimethyl-formamide; mineral oil; | Example 62A 4-trans(5-fluoro-pyridin-3-yloxy)cyclohexylamine To a stirred solution of trans-4-aminocyclohexanol (460 mg, 4 mmol) in DMF (5 mL) at 0° C. was added 60percent NaH in mineral oil (480 mg, 12 mmol). The reaction mixture was stirred at 0° C. for 1/2 hour and then <strong>[71902-33-5]3,5-difluoro-pyridine</strong> (560 mg, 4.8 mmol) was added. It was heated to 60° C. for 2 hours and stirred for 12 hours at room temperature. The reaction mixture was diluted with ethyl acetate and washed with water (3 times) and brine. The organic layer was dried (sodium sulfate), filtered, and concentrated under reduced pressure to provide the titled compound. MS (DCI) m/z 211 (M+H)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 150℃; for 0.5h;Sealed; microwave irradiation; | <strong>[298709-29-2]3,5-Difluoro-pyridine-2-carbonitrile</strong> (2 g, 14.27 mmol) and trans-1,4-aminocyclohexanol (1.644 g, 14.27 mmol) were dissolved in DMSO (12 mL). Diisopropyl-ethylamine (1.845 g, 14.27 mmol) was added and the reaction was sealed and heated to 150° C. for 30 minutes in the microwave. The reaction mixture was poured into saturated NH4Cl aq. solution (200 mL) and extracted 3 times with EtOAc (100 mL). The organics were dried with Na2SO4 and concentrated to a brown oil and purified on a 40-M (100 g) Biotage silica gel column using a 0 to 75percent EtOAc in Hexane gradient. 5-Fluoro-3-(4-hydroxy-cyclohexylamino)-pyridine-2-carbonitrile was isolated (1.214 g) as a white powder. LC/MS m/z=236 [M+H]+. | |
With potassium carbonate; In dimethyl sulfoxide; at 115℃; for 1h;Inert atmosphere; Microwave irradiation; | 500 mg of <strong>[298709-29-2]2-cyano-3,5-difluoropyridine</strong>, 493 mg of trans-4-aminocyclohexanol and 987 mg of potassium carbonate in 7.5 ml of dimethyl sulphoxide are charged to a 20 ml microwave tube-reactor.The mixture is then microwave-heated for 1 hour at 115° C.The reaction medium is run into 100 ml of water and 100 ml of ethyl acetate.The aqueous phase is re-extracted twice with 50 ml of ethyl acetate.The combined organic phases are washed with water and then with a saturated aqueous solution of sodium chloride, dried over sodium sulphate and concentrated under reduced pressure.After flash chromatography on silica gel (40-63 mum), elution being carried out with a mixture of ethyl acetate and cyclohexane (50:50 v/v), with the first eluted product being collected, 309 mg of 2-cyano-5-fluoro-3-(trans-4-hydroxycyclohexylamino)pyridine are obtained in the form of a white powder, the characteristics of which are the following:TLC on silica gel: Rf=0.20 (50/50 ethyl acetate/cyclohexane).1H NMR spectrum (400 MHz, delta in ppm, DMSO-d6): 1.20 to 1.47 (m, 4H); 1.75 to 1.89 (m, 4H); 3.32 to 3.45 (m, 2H); 4.54 (d, J=4.4 Hz, 1H); 6.23 (d, J=8.1 Hz, 1H); 7.30 (dd, J=12.1 and 2.3 Hz, 1H); 7.85 (d, J=2.4 Hz, 1H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
To a stirred solution of trans-4-aminocyclohexanol (345mg, 3 mmol) in DMF (9 mL) at 0 [C] was added 60% NaH in mineral oil (360 mg, 9 mmol). The reaction mixture was stirred at 0 C for [1/2 HOUR] and then <strong>[58656-98-7]ter<strong>[58656-98-7]t-butyl 4-fluorobenzoate</strong></strong> (706 mg, 3.6 mmol) was added. It was heated to 60 [C] for 2 hours and stirred for 12 hours at room temperature. The reaction mixture was diluted with ethyl acetate and washed with water (3 times) and brine. The organic layer was dried (sodium sulfate), filtered, and concentrated under reduced pressure to provide the titled compound. MS [(DCI) M/Z] 292 (M+H) [+.] |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
To a stirred solution of trans-4-aminocyclohexanol (460 mg, 4 mmol) in DMF (5 mL) at 0 [°C] was added 60percent NaH in mineral oil (480 mg, 12 mmol). The reaction mixture was stirred at 0 [°C] for [percent 2 HOUR] and then <strong>[71902-33-5]3,5-difluoro-pyridine</strong> (560 mg, 4.8 mmol) was added. It was heated to 60 [°C] for 2 hours and stirred for 12 hours at room temperature. The reaction mixture was diluted with ethyl acetate and washed with water (3 times) and brine. The organic layer was dried (sodium sulfate), filtered, and concentrated under reduced pressure to provide the titled compound. MS (DCI) m/z 211 (M+H) +. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In acetonitrile; at 60℃; | (0392) Trans-4-Aminocyclohexanol (0.5 g), 1-bromo-2-(2-bromoethoxyl)ethane (1.07 g) and triethylamine (2.42 ml) were dissolved in anhydrous acetonitrile (20 ml). The reaction mixture was heated at 60 C. overnight. The organic solvent was removed under vacuum. The residue was purified with flash column chromatography on silica gel eluting with 7%-10% methanol in dichloromethane to give the title compound. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In dimethyl sulfoxide; at 115℃; for 1h;microwave irradiation; | Example 128Synthesis of aminoacetic acid 4-trans-[2-carbamoyl-5-(quinolin-3-yl)-9H-carbazol-9-yl]pyridin-3-ylamino}cyclohexyl esterStage 1:500 mg of <strong>[298709-29-2]2-cyano-3,5-difluoropyridine</strong>, 493 mg of trans-4-aminocyclohexanol and 987 mg of potassium carbonate in 7.5 ml of dimethyl sulphoxide are introduced into a 5 ml microwave tube reactor.The mixture is then heated in the microwave for 1 hour at 115° C.The reaction medium is run into 100 ml of water and 100 ml of ethyl acetate.The aqueous phase is re-extracted twice with 50 ml of ethyl acetate.The combined organic phases are washed with water and then with a saturated aqueous solution of sodium chloride, dried over sodium sulphate and concentrated under reduced pressure.After purification by flash chromatography on 40 g of silica gel, elution being carried out with a mixture of ethyl acetate and cyclohexane (50/50 by volume), and the first eluted product being recovered, 309 mg of 2-cyano-5-fluoro-3-(4-trans-hydroxycyclohexylamino)pyridine are thus obtained in the form of a white powder, the characteristics of which are the following:TLC on silica gel: Rf=0.20 (ethyl acetate/cyclohexane 50/50).1H NMR spectrum (400 MHz, DMSO-d6, d ppm): 1.20-1.47 (m, 4 H) 1.75-1.89 (m, 4 H) 3.32-3.45 (m, 2 H) 4.54 (d, J=4.4 Hz, 1 H) 6.23 (d, J=8.1 Hz, 1 H) 7.30 (dd, J=12.1, 2.3 Hz, 1 H) 7.85 (d, J=2.4 Hz, 1 H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
A mixture of <strong>[313340-08-8]3,5-dichloro-6-ethylpyrazine-2-carboxamide</strong> (200 mg), 3-chloro-4-methylsulfonylaniline (374 mg) and NMP (1 mL) was stirred at 230 C. for 1 hour using a microwave reaction system. Thereafter, trans-4-aminocyclohexanol (524 mg) was added to the reaction liquid and stirred at 190 C. for 30 minutes using a microwave reaction system. After cooling, the reaction liquid was partitioned using ethyl acetate and water, and the organic layer was washed with saturated aqueous sodium hydrogen carbonate and saturated aqueous sodium chloride. After drying over anhydrous magnesium sulfate, the solvent was distilled off, and the residue was purified by silica gel column chromatography (eluent; chloroform:methanol=10:0 to 30:1) to give a crude product. This product was heated with ethanol and washed to give a light yellow solid. To the light yellow solid, ethyl acetate was added and heated, and insoluble materials were separated by filtration and the filtrate was concentrated. After the filtrate was concentrated, the residue was heated and washed with ethanol to give 3-[3-chloro-4-(methylsulfonyl)phenyl]amino}-6-ethyl-5-[(trans-4-hydroxycyclohexyl)amino]pyrazine-2-carboxamide (39 mg) as a light yellow solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72.5% | In N,N-dimethyl-formamide; toluene; at 25 - 130℃; for 12h; | 2-((1R,4R)-4-hydroxycyclohexyl) isoindoline-1,3-dione[00465] To a solution ofisobenzofuran-1,3-dione (25.0 g, 168 mmol) in DMF (160 mL)and toluene (160 mL) at 25 oc was added (1R,4R)-4-aminocyclohexanol (19.4 g, 168 mmol).The reaction was heated to 130 oc stirred at for 12 h. The reaction was diluted with H20 (200 mL), the mixture was filtered, and the filter cake was dried and evaporated under pressure to givethe title compound (30.0 g, 72.5% ). |
59% | In ethanol; for 48h;Reflux; | Example 41: Synthesis of trans-4-((6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3- d]pyPage 137 of 4072009184-0008 [00331] Synthesis of 2-(4-hydroxycyclohexyl)isoindoline-l,3-dione. A mixture of 4- aminocyclohexanol (3.9 g, 34 mmol) and isobenzofuran- l ,3-dione (4.9g, 34 mmol, 1.0 eq) in 100 mL of EtOH was heated at reflux for 2 days. EtOH was removed and the residue , was purified by column chromatography on silica gel (eluent with DCM) to give 2-(4- hydroxycyclohexyl)isoindoline-l ,3-dione as white solid (5.0 g, 59%). MS: m/z 246.0 (M+H)+. |
With isoquinoline; In N,N-dimethyl-formamide; toluene; at 130℃; for 16h; | 4-Aminocyclohexane-1-ol (3.3 g, 28.7 mmol) and phthalic anhydride (4.25 g, 28.7 mmol) were dissolved in toluene (80 mL) and DMF (35 mL),To this was added isoquinoline (0.19 g, 1.4 mmol).The reaction mixture was stirred at 130C for 16 hours. After the reaction is over,The reaction solution was diluted with ethyl acetate (50 mL), and washed successively with 5% aqueous sodium bicarbonate solution (50 mL*3) and brine (50 mL*3). The organic layers were combined and dried over anhydrous sodium sulfate.and then concentrated under reduced pressure,The residue was purified by silica gel column chromatography (eluted with pure ethyl acetate) to give compound L040-1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 0℃; for 1.5h; | To a solution of 2,4-dichloropyrimidine-5-carbonyl chloride (500 mg, 2.38 mmol) in dichloromethane (30 mL) was added methanol (87.6 mg, 2.73 mmol) and diisopropylethylamine (369 mg, 2.86 mmol) at 0 °C. The resulting mixture was stirred for 1 h at 0 °C. Then the solvent was removed. The residue (461mg, 94percent) was dissolved in IPA (20 mL) and followed by the addition of traw-4-aminocyclohexanol (301.6 mg, 2.62 mmol) then DIEA (461.4 mg, 3.57 mmol) dropwisely. The resulting mixture was stirred at 0 °C for 90 min. After which butylamine (208.8 mg, 2.86 mmol) was added, followed by DIEA (461.4 mg, 3.57 mmol). The resulting mixture was stirred at room temperature for 3 h. Water was then added. The resulting mixture was extracted with EtOAc (3X). The combined organic layers were dried (Na2SO4), filtered and concentrated. The residue was purified on ISCO to provide methyl 2-(butylamino)-4-(((trans-4-hydroxycyclohexyl)amino)pyrimidine-5- carboxylate (682.6 mg, 89percent over 3 steps). 1H NMR (400 MHz, CDCl3) delta 9.21 (s, 1H), 8.77 (s, 1H), 6.29 (s, 1H), 4.81-4.64 (m, 1H), 4.51 (s, 3H), 4.46-4.38 (m, 1H), 4.13-4.1 1 (m, 2H), 2.89-2.81 (m, 2H), 2.74 (d, J - 9.7 Hz, 2H), 2.35-2.25 (m, 2H), 2.23-2.00 (m, 6H), 1.67 (t, J = 7.2 Hz, 3H); 13C NMR (101 MHz, CDCl3) delta 167.9, 162.5, 161.3, 160.3, 95.5, 69.7, 51.2, 48.3, 41.1 , 33.8, 31.7, 30.3, 20.1, 13.8; MS m/z 323.20 [M+H]+. | |
With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 0℃; for 1.5h; | To a solution of 2,4-dichloropyrimidine-5-carbonyl chloride (500 mg, 2.38 mmol) in dichloromethane (30 mL) was added methanol (87.6 mg, 2.73 mmol) and diisopropyeihylamine (369 mg, 2,86 mmol) at 0 °C. The resulting mixture was stirred for 1 h at 0 °C. Then the solvent was removed. The residue (461rng, 94percent) was dissolved in IPA (20 ml,) and followed by the addition of trans-4-aminocyclohexanol (301.6 mg, 2.62 mmol) then DIEA (461.4 mg, 3.57 mmol) dropwiseiy. The resulting mixture was stirred at 0 °C for 90 min. After which buiyiamine (208,8 mg, 2.86 mmol) was added, followed by DIEA (461.4 mg., 3.57 mmol). The resulting mixture was stirred at room temperature for 3 h. Water was then added. The resulting mixture was extracted with EtOAc (3X). The combined organic layers were dried (Na2SO4, filtered and concentrated. The residue was purified on ISCO to give methyl 2-(butylamino)-4-((trans-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxylate (682.6 mg, 89percent over 3 steps). 1H NMR (400 MHz, CDCl3) delta 9.21 (s, 1H), S.77 (s, 1H), 6.29 (s, 1H), 4.81 - 4.64 (m, 1H), 4.51 (s, 3H), 4.46-4.38 (m, 1H), 4.13-4.1 (m, 2H), 2.89-2.81 (m, 2H), 2.74 (d, J - 9.7 Hz, 2H), 2.35 - 2.25 (m, 2H), 2.23 - 2.00 (m, 6H), 1 ,67 (t, J- 7.2 Hz, 3H); 13C NMR (101 MHz, CDCl3) delta 167.9, 162,5, 161.3, 160.3, 95.5, 69.7, 51.2, 48.3, 41. L 33.8, 31 ,7, 30.3, 20.1, 13,8; MS m/z 323.20 [M+H]+ | |
With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 0℃; for 1.5h; | Methyl 2-(butYlaminoV4-(((tra^^ (0734) (0735) To a solution of 2,4-dichloropyrimidine-5-carbonyl chloride (500 mg, 2.38 mmol) in dichloromethane (30 mL) was added methanol (87.6 mg, 2.73 mmol) and diisopropylethylamine (369 mg, 2.86 mmol) at 0 °C. The resulting mixture was stirred for 1 h at 0 °C. Then the solvent was removed. The residue (461mg, 94percent) was dissolved in IP A (20 mL) and followed by the addition of tra5'-4-aminocyclohexanol (301.6 mg, 2.62 mmol) then DIEA (461.4 mg, 3.57 mmol) dropwisely. The resulting mixture was stirred at 0 °C for 90 min. After which butylamine (208.8 mg, 2.86 mmol) was added, followed by DIEA (461.4 mg, 3.57 mmol). The resulting mixture was stirred at room temperature for 3 h. Water was then added. The resulting mixture was extracted with EtOAc (3X). The combined organic layers were dried filtered and concentrated. The residue was purified on ISCO to provide methyl 2-(butylamino)-4-(((traj,-4-hydroxycyclohexyl)amino)pyrimidine-5 - carboxylate (682.6 mg, 89percent over 3 steps). 1H NMR (400 MHz, CDC13) delta 9.21 (s, 1H), 8.77 (s, 1H), 6.29 (s, 1H), 4.81-4.64 (m, 1H), 4.51 (s, 3H), 4.46-4.38 (m, 1H), 4.13-4.11 (m, 2H), 2.89-2.81 (m, 2H), 2.74 (d, J = 9.7 Hz, 2H), 2.35-2.25 (m, 2H), 2.23-2.00 (m, 6H), 1.67 (t, J = 7.2 Hz, 3H); 13C NMR (101 MHz, CDC13) delta 167.9, 162.5, 161.3, 160.3, 95.5, 69.7, 51.2, 48.3, 41.1, 33.8, 31.7, 30.3, 20.1, 13.8; MS m/z 323.20 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
31% | In DMF (20 mL) was dissolved (s)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2 -(hydroxymethyl)tetrahydropyrrole-1-yl)-5-pyrimidine carboxylic acid (3.9 g, 10 mmol). The solution was cooled in an ice bath. HATU (5.67 g, 15 mmol) and DIPEA (1.93 g, 15 mmol) were added. After 20 min, trans-4-aminocyclohexanol (1.39 g, 12 mmol) was added in batches. The reaction was conducted overnight. LC-MS was used to monitor the reaction. Ethyl acetate (50 mL) and water (50 mL) were added. The separate aqueous phase was washed with ethyl acetate twice. The organic phase was combined, dried, concentrated and purified by silica gel column chromatography (VDCM:VMeOH = 15:1) to give the product (1.5 g, 31 % yield). Molecular formula: C24H32ClN5O4 Molecular weight: 489.21 LC-MS(M/e): 490.11 (M+H+) 1H-NMR (400 MHz, CDCl3): δ 9.63 (1H, s), 8.15 (1H, s), 7.35(1H, s), 7.19 (1H, d), 7.1 (1H, d), 6.26 (1H, s), 4.58 (2H, d), 4.05-4.13 (1H, m), 3.79-3.90 (6H, m), 3.56-3.69 (3H, m), 2.22-2.27 (2 H, m), 1.72-2.17 (8H, m), 1.26-1.45 (4H, m). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
31% | A mixture of 3,5-dichloro-6-methylpyrazine-2-carboxamide (3d,61 mg, 0.296 mmol), 3-(methanesulfonyl)aniline (56 mg, 0.327 mmol), DIPEA (51 muL, 0.293 mmol) and 1,4-dioxane (20 mL) in a sealed tube was stirred at 170 C for 40 h. After the mixture was cooled, saturated aqueous NaHCO3 solution was added, and the resulting slurry was extracted with EtOAc. The organic layer was dried over MgSO4 and concentrated in vacuo. To this residue were added 3-(methanesulfonyl)aniline (76 mg, 0.444 mmol) and DMI (1 mL), and the mixture was irradiated with microwaves at 220 C for 1 h. To this reaction mixture was added (1r,4r)-4-aminocyclohexan-1-ol (171 mg, 1.48 mmol), and the mixture was irradiated with microwaves at 190 C for 30 min. EtOAc was added to the reaction mixture, and the organic layer was washed with saturated aqueous NaHCO3 solution and brine, dried over anhydrous MgSO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (CHCl3/MeOH=100:0 to 30:1).The resulting product was washed with EtOAc to give 5d (38 mg, 31%)as a pale yellow solid. 1H NMR (DMSO-d6): delta 1.30-1.51 (4H, m),1.75-1.98 (4H, m), 2.27 (3H, s), 3.21 (3H, s), 3.36-3.48 (1H, m),3.87-4.00 (1H, m), 4.53 (1H, d, J=4.4 Hz), 6.72 (1H, d, J=8.0 Hz),7.33 (1H, d, J=2.0 Hz), 7.44-7.58 (2H, m), 7.68 (1H, d, J=2.4 Hz),7.95-8.03 (1H, m), 8.16-8.22 (1H, m), 11.60 (1H, s); MS (ESI) m/z[M+H]+ 420; HRMS (ESI) m/z Calcd for C19H26N5O4S [M+H]+:420.1700, Found: 420.1697. |
Tags: 27489-62-9 synthesis path| 27489-62-9 SDS| 27489-62-9 COA| 27489-62-9 purity| 27489-62-9 application| 27489-62-9 NMR| 27489-62-9 COA| 27489-62-9 structure
A283033 [6850-65-3]
4-Aminocyclohexan-1-ol(only contains trans)
Similarity: 1.00
A153433 [50910-54-8]
trans-4-Aminocyclohexanol hydrochloride
Similarity: 0.95
A321832 [76445-65-3]
4-Aminocyclohexanol hydrochloride
Similarity: 0.95
A353503 [56239-26-0]
cis-4-Aminocyclohexanol hydrochloride
Similarity: 0.95
A283033 [6850-65-3]
4-Aminocyclohexan-1-ol(only contains trans)
Similarity: 1.00
A153433 [50910-54-8]
trans-4-Aminocyclohexanol hydrochloride
Similarity: 0.95
A321832 [76445-65-3]
4-Aminocyclohexanol hydrochloride
Similarity: 0.95
A353503 [56239-26-0]
cis-4-Aminocyclohexanol hydrochloride
Similarity: 0.95
A283033 [6850-65-3]
4-Aminocyclohexan-1-ol(only contains trans)
Similarity: 1.00
A153433 [50910-54-8]
trans-4-Aminocyclohexanol hydrochloride
Similarity: 0.95
A321832 [76445-65-3]
4-Aminocyclohexanol hydrochloride
Similarity: 0.95
A353503 [56239-26-0]
cis-4-Aminocyclohexanol hydrochloride
Similarity: 0.95
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :
Total Compounds: mg
The concentration of the dissolution solution you need to prepare is mg/mL