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Chemical Structure| 27427-66-3 Chemical Structure| 27427-66-3
Chemical Structure| 27427-66-3
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Product Details of [ 27427-66-3 ]

CAS No. :27427-66-3
Formula : C5H3Cl2N3O
M.W : 192.00
SMILES Code : NC(=O)C1=C(Cl)N=NC(Cl)=C1
MDL No. :MFCD11646064
InChI Key :NXVUUPORAZUSGG-UHFFFAOYSA-N
Pubchem ID :262049

Safety of [ 27427-66-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 27427-66-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 27427-66-3 ]

[ 27427-66-3 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 27427-66-3 ]
  • [ 35857-93-3 ]
YieldReaction ConditionsOperation in experiment
99% at 90℃; for 1 h; A mixture of 3,6-dichloropyridazine-4-carboxamide (5.7 g, 29.69 mmol, 1.00 equiv) and phosphorus oxychloride (50 mL) was heated to reflux for 1 hour. The resulting mixture wasconcentrated under vacuum and the residue was dissolved in dichloromethane. The resulting solution was washed with water and brine, dried over anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified by silica gel column chromatography eluting with ethyl acetate/petroleum ether (1:5). This resulted in the title compound (5.1 g, 99percent) as a light yellow solid.
References: [1] Patent: WO2015/25025, 2015, A1, . Location in patent: Page/Page column 408.
[2] Patent: WO2017/133665, 2017, A1, . Location in patent: Page/Page column 40.
  • 2
  • [ 108-77-0 ]
  • [ 27427-66-3 ]
  • [ 35857-93-3 ]
References: [1] Patent: WO2017/133667, 2017, A1, . Location in patent: Page/Page column 444.
 

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