[ CAS No. 27148-03-4 ] {[proInfo.proName]}

Name: 27148-03-4|Benzo[d]isothiazole-3(2H)-thione 1,1-dioxide|95%
Brand: Ambeed
SKU: A275874
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Quality Control of [ 27148-03-4 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 27148-03-4 ]

Product Details of [ 27148-03-4 ]

CAS No. :	27148-03-4	MDL No. :	MFCD18451364
Formula :	C₇H₅NO₂S₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	BAVQVWLILLHJKA-UHFFFAOYSA-N
M.W :	199.25	Pubchem ID :	3035171
Synonyms :

Calculated chemistry of [ 27148-03-4 ]

Physicochemical Properties

Num. heavy atoms :	12
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.0
Num. rotatable bonds :	0
Num. H-bond acceptors :	2.0
Num. H-bond donors :	1.0
Molar Refractivity :	52.09
TPSA :	86.64 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.44 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.03
Log Po/w (XLOGP3) :	1.51
Log Po/w (WLOGP) :	1.35
Log Po/w (MLOGP) :	0.43
Log Po/w (SILICOS-IT) :	2.02
Consensus Log Po/w :	1.27

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.4
Solubility :	0.799 mg/ml ; 0.00401 mol/l
Class :	Soluble
Log S (Ali) :	-2.94
Solubility :	0.23 mg/ml ; 0.00115 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-2.74
Solubility :	0.36 mg/ml ; 0.00181 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.43

Safety of [ 27148-03-4 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 27148-03-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 27148-03-4 ]
Downstream synthetic route of [ 27148-03-4 ]

[ 27148-03-4 ] Synthesis Path-Upstream 1~2

1
[ 27148-03-4 ]
[ 936-16-3 ]

Reference： [1] Journal of Chemical Research, Miniprint, 1990, # 4, p. 756 - 784
[2] Journal of Chemical Research, Miniprint, 1990, # 4, p. 756 - 784

2
[ 81-07-2 ]
[ 27148-03-4 ]

Reference： [1] Pharmazie, 2005, vol. 60, # 10, p. 723 - 731
[2] Gazzetta Chimica Italiana, 1916, vol. 46 I, p. 234,236
[3] Gazzetta Chimica Italiana, 1915, vol. 45 I, p. 547
[4] Journal of Organic Chemistry, 1951, vol. 16, p. 1582,1585
[5] Journal of Chemical Crystallography, 1994, vol. 24, # 9, p. 581 - 586
[6] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2008, vol. 63, # 7, p. 877 - 879
[7] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2007, vol. 62, # 12, p. 1530 - 1534
[8] Inorganica Chimica Acta, 2018, vol. 479, p. 266 - 274

[ 27148-03-4 ] Synthesis Path-Downstream 1~69

1
[ 27148-03-4 ]
[ 77-78-1 ]
[ 71-43-2 ]
[ 61766-82-3 ]

Reference： [1]Journal of Organic Chemistry,1951,vol. 16,p. 1582,1585

2
[ 27148-03-4 ]
[ 7668-28-2 ]

Reference： [1]Gazzetta Chimica Italiana,1940,vol. 70,p. 855,873
[2]Gazzetta Chimica Italiana,1940,vol. 70,p. 855,873
[3]Pharmazie,2005,vol. 60,p. 723 - 731

3
[ 81-07-2 ]
[ 27148-03-4 ]

Reference： [1]Pharmazie,2005,vol. 60,p. 723 - 731
[2]Gazzetta Chimica Italiana,1916,vol. 46 I,p. 234,236
[3]Journal of Organic Chemistry,1951,vol. 16,p. 1582,1585
[4]Journal of Chemical Crystallography,1994,vol. 24,p. 581 - 586
[5]Zeitschrift fur Naturforschung, B: Chemical Sciences,2008,vol. 63,p. 877 - 879
[6]Zeitschrift fur Naturforschung, B: Chemical Sciences,2007,vol. 62,p. 1530 - 1534
[7]Inorganica Chimica Acta,2018,vol. 479,p. 266 - 274

4
[ 27148-03-4 ]
[ 4702-38-9 ]
[ 32729-69-4 ]

Reference： [1]Tetrahedron Letters,1971,p. 525 - 528

5
[ 27148-03-4 ]
[ 936-16-3 ]

Reference： [1]Journal of Chemical Research, Miniprint,1990,p. 756 - 784
[2]Journal of Chemical Research, Miniprint,1990,p. 756 - 784

6
[ 27148-03-4 ]
3-hydrazinosaccharin [ No CAS ]

Reference： [1]Journal of the Indian Chemical Society,1997,vol. 74,p. 314 - 315

8
[ 27148-03-4 ]
KOH-solution [ No CAS ]
[ 632-24-6 ]

Reference： [1]Gazzetta Chimica Italiana,1915,vol. 45 I,p. 547

9
[ 27148-03-4 ]
[ 7732-18-5 ]
[ 81-07-2 ]

Reference： [1]Gazzetta Chimica Italiana,1915,vol. 45 I,p. 547

10
[ 27148-03-4 ]
alkaline solution [ No CAS ]
[ 81-07-2 ]

Reference： [1]Gazzetta Chimica Italiana,1915,vol. 45 I,p. 547

11
[ 74-96-4 ]
[ 27148-03-4 ]
[ 64404-64-4 ]

Reference： [1]Pharmazie,2005,vol. 60,p. 723 - 731

12
[ 27148-03-4 ]
[ 107-14-2 ]
[ 80357-08-0 ]

Reference： [1]Pharmazie,2005,vol. 60,p. 723 - 731

13
[ 27148-03-4 ]
[ 869651-63-8 ]

Reference： [1]Pharmazie,2005,vol. 60,p. 723 - 731

14
[ 27148-03-4 ]
[ 869651-40-1 ]

Reference： [1]Pharmazie,2005,vol. 60,p. 723 - 731

15
[ 27148-03-4 ]
(S)-2-(1,1-dioxobenzo[d]isothiazol-3-ylamino)-4-methylpentanamide [ No CAS ]

Reference： [1]Pharmazie,2005,vol. 60,p. 723 - 731

16
[ 27148-03-4 ]
[ 869651-62-7 ]

Reference： [1]Pharmazie,2005,vol. 60,p. 723 - 731

17
[ 27148-03-4 ]
[ 869651-39-8 ]

Reference： [1]Pharmazie,2005,vol. 60,p. 723 - 731

18
[ 27148-03-4 ]
(S)-2-(1,1-dioxobenzo[d]isothiazol-3-ylamino)-3-phenylpropanamide [ No CAS ]

Reference： [1]Pharmazie,2005,vol. 60,p. 723 - 731

19
[ 27148-03-4 ]
[N'-(1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-ylidene)-hydrazino]-acetic acid ethyl ester [ No CAS ]

Reference： [1]Journal of the Indian Chemical Society,1997,vol. 74,p. 314 - 315

20
[ 27148-03-4 ]
[ 51674-07-8 ]

Reference： [1]Gazzetta Chimica Italiana,1940,vol. 70,p. 855,873

21
[ 27148-03-4 ]
[ 60871-49-0 ]
Methyl 2-[(1,1-dioxo-1,2-benzoisothiazol-3-yl)thio]-3-(4-benzyloxyphenyl)propionate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide; In methanol; for 5h;Heating / reflux;	Step A: Methyl 2-[(1,1-dioxo-1,2-benzoisothiazol-3-yl)thio]-3-(4-benzyloxyphenyl)propionate The solution of 0.3 g (0.001 mol) of methyl 3-[4-(benzyloxy)phenyl]-2-chloropropionate in methanol (2 ml) was added dropwise to the solution of 0.2 g (0.001 mol) 1,1-dioxo-1,2-benzoisothiazol-3(2H)-thione (<strong>[27148-03-4]thiosaccharine</strong>) and 0.04 g (0.001 mol) NaOH in methanol (3 ml). The solution thus obtained was heated at reflux for 5 h. The crude product obtained after evaporating the solvent was used without purification in the next step of the synthesis.

Reference： [1]Patent: US2006/160870,2006,A1 .Location in patent: Page/Page column 11

22
[ 27148-03-4 ]
potassium hydroxide [ No CAS ]
potassium thiosaccharinate monohydrate [ No CAS ]

Reference： [1]Acta Crystallographica, Section C: Crystal Structure Communications,1991,vol. 47,p. 1821 - 1823

23
[ 66-71-7 ]
[ 27148-03-4 ]
thallium chloride [ No CAS ]
[ 674287-41-3 ]

Reference： [1]Zeitschrift fur Anorganische und Allgemeine Chemie,2003,vol. 629,p. 1975 - 1979

24
[ 27148-03-4 ]
thallium chloride [ No CAS ]
thallium(I) thiosaccharinate [ No CAS ]

Reference： [1]Zeitschrift fur Anorganische und Allgemeine Chemie,2003,vol. 629,p. 1975 - 1979

25
[ 51-17-2 ]
[ 67-56-1 ]
[ 27148-03-4 ]
cadmium(II) nitrate tetrhydrate [ No CAS ]
[ 914459-72-6 ]

Reference： [1]Journal of Molecular Structure,2006,vol. 797,p. 56 - 60

26
[ 27148-03-4 ]
[ 92054-75-6 ]
[ 954103-46-9 ]

Reference： [1]Journal of Molecular Structure,2007,vol. 841,p. 110 - 117

27
[ 366-18-7 ]
[ 27148-03-4 ]
silver nitrate [ No CAS ]
[ 954103-47-0 ]

Reference： [1]Journal of Molecular Structure,2007,vol. 841,p. 110 - 117

28
[ 27148-03-4 ]
silver nitrate [ No CAS ]
poly[(μ3-1,1-dioxo-1,2-benzoisothiazole-3-thiolato-κ(3)N:S(3):S(3))silver(I)] [ No CAS ]

Reference： [1]Journal of Molecular Structure,2007,vol. 841,p. 110 - 117
[2]Acta Crystallographica, Section C: Crystal Structure Communications,2007,vol. 63,p. m395-m397

29
[ 110-86-1 ]
[ 27148-03-4 ]
silver nitrate [ No CAS ]
[ 1055310-56-9 ]

Reference： [1]Polyhedron,2008,vol. 27,p. 2243 - 2250

30
[ 66-71-7 ]
[ 27148-03-4 ]
silver nitrate [ No CAS ]
[ 1055310-57-0 ]

Reference： [1]Polyhedron,2008,vol. 27,p. 2243 - 2250

31
[ 124-09-4 ]
[ 27148-03-4 ]
hexamethylenediammonium bis(thiosaccharinate) [ No CAS ]

Reference： [1]Zeitschrift fur Naturforschung, B: Chemical Sciences,2007,vol. 62,p. 1530 - 1534

32
[ 27148-03-4 ]
bis(acetylacetonato)palladium(II) [ No CAS ]
[ 2071-20-7 ]
[ 1223048-96-1 ]

Reference： [1]Zeitschrift fur Anorganische und Allgemeine Chemie,2009,vol. 635,p. 1604 - 1612

33
[ 27148-03-4 ]
bis(acetylacetonato)palladium(II) [ No CAS ]
palladium(II) thiosaccharinate [ No CAS ]

Reference： [1]Zeitschrift fur Anorganische und Allgemeine Chemie,2009,vol. 635,p. 1604 - 1612

34
[ 27148-03-4 ]
bis(acetylacetonato)palladium(II) [ No CAS ]
[ 603-35-0 ]
[ 75-05-8 ]
[ 1223048-87-0 ]

Reference： [1]Zeitschrift fur Anorganische und Allgemeine Chemie,2009,vol. 635,p. 1604 - 1612

35
[ 27148-03-4 ]
bis(acetylacetonato)palladium(II) [ No CAS ]
[ 75-05-8 ]
[ 1663-45-2 ]
[ 1223049-00-0 ]
Pd₂(C₆H₄CSNSO₂)2(CH₂P(C₆H₅)2)4 [ No CAS ]

Reference： [1]Zeitschrift fur Anorganische und Allgemeine Chemie,2009,vol. 635,p. 1604 - 1612

36
[ 27148-03-4 ]
[ 64-17-5 ]
[ 13453-07-1 ]
[ 2071-20-7 ]
[ 1340587-84-9 ]

Reference： [1]Inorganica Chimica Acta,2011,vol. 377,p. 77 - 83

37
[ 27148-03-4 ]
[ 13453-07-1 ]
[ 603-35-0 ]
[ 1340587-82-7 ]

Reference： [1]Inorganica Chimica Acta,2011,vol. 377,p. 77 - 83

38
[ 27148-03-4 ]
[ 64-17-5 ]
[ 13453-07-1 ]
[ 1663-45-2 ]
μ-bis(diphenylphosphino)ethane-κP,P'-bis[(1,1-dioxide-1,2-benzoisothiazol-3-thionato-κS) gold(I)] solvato ethanol [ No CAS ]

Reference： [1]Inorganica Chimica Acta,2011,vol. 377,p. 77 - 83

39
[ 27148-03-4 ]
[ 64-17-5 ]
gold(I) chloride [ No CAS ]
Au(thiosaccharin)2(thiosaccharin(-1H))*0.25EtOH [ No CAS ]

Reference： [1]Inorganica Chimica Acta,2011,vol. 377,p. 77 - 83

40
[ 27148-03-4 ]
bismuth(III) tert-butoxide [ No CAS ]
bismuth tris(thiosaccharinate) [ No CAS ]

Reference： [1]Organometallics,2011,vol. 30,p. 6283 - 6291

41
[ 27148-03-4 ]
[ 603-33-8 ]
bismuth tris(thiosaccharinate) [ No CAS ]
phenylbismuth bis(thiosaccharinate) [ No CAS ]
diphenylbismuth(III) thiosaccharinate [ No CAS ]

Reference： [1]Organometallics,2011,vol. 30,p. 6283 - 6291

42
[ 27148-03-4 ]
[ 603-33-8 ]
phenylbismuth bis(thiosaccharinate) [ No CAS ]

Reference： [1]Organometallics,2011,vol. 30,p. 6283 - 6291

43
[ 27148-03-4 ]
[ 603-33-8 ]
diphenylbismuth(III) thiosaccharinate [ No CAS ]

Reference： [1]Organometallics,2011,vol. 30,p. 6283 - 6291

44
[ 27148-03-4 ]
[ 954103-47-0 ]

Reference： [1]Journal of Molecular Structure,2007,vol. 841,p. 110 - 117

45
[ 27148-03-4 ]
[ 954103-46-9 ]

Reference： [1]Journal of Molecular Structure,2007,vol. 841,p. 110 - 117

46
[ 27148-03-4 ]
[ 1223048-91-6 ]

Reference： [1]Zeitschrift fur Anorganische und Allgemeine Chemie,2009,vol. 635,p. 1604 - 1612

47
[ 27148-03-4 ]
[ 1223048-96-1 ]

Reference： [1]Zeitschrift fur Anorganische und Allgemeine Chemie,2009,vol. 635,p. 1604 - 1612

48
[ 27148-03-4 ]
[ 1223049-00-0 ]

Reference： [1]Zeitschrift fur Anorganische und Allgemeine Chemie,2009,vol. 635,p. 1604 - 1612

49
[ 27148-03-4 ]
[ 1223048-87-0 ]

Reference： [1]Zeitschrift fur Anorganische und Allgemeine Chemie,2009,vol. 635,p. 1604 - 1612

50
[ 27148-03-4 ]
[ 1416047-04-5 ]

Reference： [1]Journal of Molecular Structure,2013,vol. 1032,p. 48 - 55

51
[ 27148-03-4 ]
[ 52595-94-5 ]
C₃₉H₃₀N₂O₄P₂PtS₄*0.5CHCl₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	With triethylamine; In chloroform; for 1h;Reflux;	General procedure: For 6: A solution of thiosaccharin (tsacH) (0.06 g, 0.307 mmol) in chloroform (8 cm3) was added to a solution of [PtCl2(kappa2-dppm)] (0.10 g, 0.154 mmol) in chloroform (10 cm3). A few drops of triethylamine were added and the resulting mixture was heated under reflex for 1 h. This produced a yellow solution was filtered off and reduced to half volume. Methanol (2 cm3) was added and the mixture was set a side to evaporate slowly at room temperature. The yellow crystalline solid thus formed was filtered off and dried in a vacuum oven (0.12 g, 91%).

Reference： [1]Inorganica Chimica Acta,2013,vol. 398,p. 117 - 123

52
[ 27148-03-4 ]
[ 52595-94-5 ]
C₆₄H₅₂N₂O₄P₄PtS₄*0.5CH₂Cl₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%	With triethylamine; In chloroform; for 1h;Reflux;	A solution of thiosaccharin (tsacH) (0.084 g, 0.425 mmol) in chloroform (10 cm3) was added to a solution of [Pt(kappa2-dppm)2]Cl2 (0.22 g, 0.22 mmol) in chloroform (10 cm3). A few drops of triethylamine were added and the resulting mixture was heated under reflex for 1 h. This produced a yellow solution which was filtered and reduced to half volume. Methanol (2 cm3) was added and the mixture was set aside to evaporate slowly at room temperature. The pale yellow crystalline solid thus formed was filtered off and dried in a vacuum oven (85%). 11: pale yellow solid, 85% yield. 1H NMR: delta 7.57 (d, J 7.60 Hz, 4H, Ar), 7.50-6.80 (m, 44 H, Ar), 3.46 (br, 4H, CH2); 31P{1H} NMR: 253 K 18.1 (br), -30.4 (br) ppm; 298 K 16.8 (vbr), -28.1 (vbr) ppm; 333 K -23.3 (vbr) ppm; IR(KBr) 3053w, 2932w, 1431s, 1313vs, 1159vs, 994s, 800s, 694s, 378m cm-1; Elemental Anal. Calc. for PtN2S4P4O4C64H52·0.5CH2Cl2. Found: C, 55.42 (55.00); H, 3.79 (3.66); N: 2.00 (1.97)%.

Reference： [1]Inorganica Chimica Acta,2013,vol. 398,p. 117 - 123

53
[ 27148-03-4 ]
[ 83095-83-4 ]
C₄₀H₃₂N₂O₄P₂PtS₄*CH₂Cl₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
81%	With triethylamine; In chloroform; for 1h;Reflux;	General procedure: For 6: A solution of thiosaccharin (tsacH) (0.06 g, 0.307 mmol) in chloroform (8 cm3) was added to a solution of [PtCl2(kappa2-dppm)] (0.10 g, 0.154 mmol) in chloroform (10 cm3). A few drops of triethylamine were added and the resulting mixture was heated under reflex for 1 h. This produced a yellow solution was filtered off and reduced to half volume. Methanol (2 cm3) was added and the mixture was set a side to evaporate slowly at room temperature. The yellow crystalline solid thus formed was filtered off and dried in a vacuum oven (0.12 g, 91%).

Reference： [1]Inorganica Chimica Acta,2013,vol. 398,p. 117 - 123

54
[ 27148-03-4 ]
[ 59329-00-9 ]
[ 1429789-37-6 ]

Yield	Reaction Conditions	Operation in experiment
82%	With triethylamine; In chloroform; for 1h;Reflux;	General procedure: For 6: A solution of thiosaccharin (tsacH) (0.06 g, 0.307 mmol) in chloroform (8 cm3) was added to a solution of [PtCl2(kappa2-dppm)] (0.10 g, 0.154 mmol) in chloroform (10 cm3). A few drops of triethylamine were added and the resulting mixture was heated under reflex for 1 h. This produced a yellow solution was filtered off and reduced to half volume. Methanol (2 cm3) was added and the mixture was set a side to evaporate slowly at room temperature. The yellow crystalline solid thus formed was filtered off and dried in a vacuum oven (0.12 g, 91%).

Reference： [1]Inorganica Chimica Acta,2013,vol. 398,p. 117 - 123

55
[ 27148-03-4 ]
[ 65097-96-3 ]
[ 1429789-52-5 ]

Yield	Reaction Conditions	Operation in experiment
80%	With triethylamine; In chloroform; for 1h;Reflux;	General procedure: For 6: A solution of thiosaccharin (tsacH) (0.06 g, 0.307 mmol) in chloroform (8 cm3) was added to a solution of [PtCl2(kappa2-dppm)] (0.10 g, 0.154 mmol) in chloroform (10 cm3). A few drops of triethylamine were added and the resulting mixture was heated under reflex for 1 h. This produced a yellow solution was filtered off and reduced to half volume. Methanol (2 cm3) was added and the mixture was set a side to evaporate slowly at room temperature. The yellow crystalline solid thus formed was filtered off and dried in a vacuum oven (0.12 g, 91%).

Reference： [1]Inorganica Chimica Acta,2013,vol. 398,p. 117 - 123

56
[ 10025-99-7 ]
[ 27148-03-4 ]
2C₇H₄NO₂S₂^(1-)*Pt⁽²⁺⁾*H₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
71%	In methanol; water; for 2h;Reflux;	A solution of thiosaccharin (tsacH) (0.04 g, 0.24 mmol) in methanol (8 cm3) was added to a solution of K2[PtCl4] (0.05 g, 0.12 mmol) in water (3 cm3). The orange mixture was heated at reflux on a steam bath for 2 h. After cooling to room temperature the brown solid formed was filtered off, washed with water and dried in a vacuum oven to give 1 (0.049 g, 70%). 1H NMR (d6-dmso): delta 8.50 (d, J 7.0 Hz, 2H), 8.86 (d, J 6.8 Hz, 2H), 7.76 (m, 4H); IR v/cm-1; IR(KBr) 3085w, 1419s, 1340vs, 1100vs, 1012s, 804vs, 366m cm-1; Elemental Anal. Calc. for PtS4N2O4C14H8·H2O. Found: C, 27.58 (27.63); H, 1.64 (1.49); N, 4.60 (4.59)%.

Reference： [1]Inorganica Chimica Acta,2013,vol. 398,p. 117 - 123

57
[ 15663-27-1 ]
[ 27148-03-4 ]
cis-[Pt(II)(thiosaccharinate)₂(NH₃)₂] [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
89%	In water; for 2h;Reflux;	a solution of thiosaccharinate (0.26 g, 1.33 mmol) in hot water (30 cm3) was added to a solution of cis-[PtCl2(NH3)2] (0.20 g, 0.667 mmol) in hot water (15 cm3). The mixture was reuxed for 2 h. The light-brown solid formed was ltered off washed several times with distilled water and dried in vacuo. Yield: 89% (0.39 g). Anal. Calcd. for C14H14N4O4PtS4: C, 26.88; H, 2.26; N,8.96. Found: C, 26.33; H, 2.09; N, 8.86%. IR (KBr) (nu, cm-1): 3471 m, 3413 m, 3286 m, 1627s,1440w, 1373s, 1315s, 1236 m, 1155 m, 1126s, 1008w, 817 s, 515 m. 1H NMR (d6-DMSO): 7.96-7.90 (m, 4H), 7.82-7.75 (m, 4H), 4.54 (s, 6 H). 13C{1H} NMR (d6-DMSO): 182.8, 137.6,133.7, 133.4, 133.1, 124.3, 120.7 ppm.

Reference： [1]Journal of Inorganic Biochemistry,2014,vol. 141,p. 55 - 57

58
[ 27148-03-4 ]
[Pd(benzisothiazolinate)₂]*H₂O [ No CAS ]
[Pd(benzisothiazolinate)(thiosaccharin)] [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
79%	In methanol; chloroform; for 3.16667h;	General procedure: Thiosaccharin (Htsac) (0.070 g, 0.353 mmol) in MeOH (5 cm3)was added to a suspension of 1 (0.150 g, 0.353 mmol) in CHCl3(8 cm3). The mixture was stirred for 3 h and refluxed on a steambath for 10 min. The orange-red solid thus formed was collected,washed with EtOH and dried in a vacuum oven (yield: 0.128 g,79%). Anal. Calc. for C14H8N2O3PdS3: C, 36.97; H, 1.77; N, 6.16.Found: C, 37.12; H, 1.96; N, 6.30%. IR (KBr); 3049w, 1632s,1562m, 1443m, 1423m, 1016m, 804m, 439m, 413m cm1. 1HNMR (d6-dmso): d 7.95 (d, J 8.1, 1H, tsac), 7.89-7.73 (m, 5H, tsac& bit), 7.6 (t, J 7.5, 1H, bit), 7.41 (t, J 7.5, 1H, bit) ppm.Decomposes at 282 C.

Reference： [1]Inorganica Chimica Acta,2015,vol. 436,p. 7 - 15

59
[ 27148-03-4 ]
[ 19046-92-5 ]
trans-[Pd(S-thiosaccharinate )₂(benzylamine)₂] [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75%	In methanol; at 30℃; for 2h;	A solution of tsac (0.051 g, 0.26 mmol) in MeOH (5 cm3)was added to a solution of 1 (0.051 g, 0.13 mmol) inMeOH (10 cm3). The mixture was stirred at 30 C for 2 h.The yellow-orange solid formed was collected by filtrationand dried under vacuum. Yield 0.068 g, 75%. Anal. Calc.for C28H26N4O4PdS4: C, 46.9, H, 3.7, N, 7.8. Found: C,46.9, H, 3.8, N, 8.0. Molar conductivity (DMSO): 0.40(X-1 mol-1 cm-1). IR (KBr): 3425sb, 3051w, 2922w,1541m, 1463m, 1384s, 1163s, 1004m, 806m, 370s cm-1.1H NMR (DMSO-d6): d 7.89 (dd, J 8.0, J 3.2, 4H, tsac),7.71 (t, J 8.0, 2H, tsac), 7.58 (t, J 8.0, 2H, tsac), 7.29 (s,10H, Ph), 4.58 (bs, 4H, 2NH2), 3.69 (s, 4H, 2CH2) ppm.

Reference： [1]Transition Metal Chemistry,2017,vol. 42,p. 79 - 84

60
[ 27148-03-4 ]
zinc(II) nitrate hexahydrate [ No CAS ]
[ 119-91-5 ]
2C₇H₄NO₂S₂^(1-)*Zn⁽²⁺⁾*C₁₈H₁₂N₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%		A Zn(NO3)2*6H2O dissolution (10.3 mg, 0.0346 mmol/2 ml ethanol:water 1:1) was added to another dissolution of <strong>[27148-03-4]thiosaccharine</strong> (12.3 mg, 0.062 mmol/2 ml ethanol:water 1:1). Finally, solid 2,2'-biquinoline was added (9.4 mg, 0.0367 mmol/2 ml ethanol:water1:1). A pale yellow powder was then obtained. Yield: 90%. Molar conductivity (mS M1) = 26.3. Analytical percent composition calculated for C32H20N4O4S4Zn: C = 53.520%; H = 2.807%; N = 7.801%. Found: C = 53.884%; H = 2.761%; N = 7.698%. Soluble in DMSO and DMF. Almost insoluble in water, ethanol, methanol, acetone, dichloromethane and chloroform. [DMSO, kmaxnm]: 339 1H NMR (300 MHz, DMSO) d 8.80 (dd, 1H), 8.58 (dd, 1H), 8.19(dd, 1H), 8.08 (dd, 1H), 7.89-7.95 (m, 1H), 7.85 (td, 1H), 7.53-7.73 (m, 4H). 13C NMR (75 MHz, DMSO) d 191.54 (C1), 155.21(C16), 147.16 (C8), 137.80 (C7), 137.36 (C14), 136.32 (C2), 132.16 (C4), 130.99 (C5), 130.18 (C10), 129.31 (C12), 128.16 (C13), 128.03(C11), 127.42 (C9), 125.10 (C3), 119.05 (C6), 118.87 (C15).

Reference： [1]Inorganica Chimica Acta,2018,vol. 479,p. 266 - 274

61
[ 66-71-7 ]
[ 27148-03-4 ]
zinc(II) nitrate hexahydrate [ No CAS ]
[Zn(1,1-dioxo-1,2-benzisothiazole-3-thiolato)₂(o-phenantroline)] [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
74%		The [Zn(tsac)2(o-phen)] complex was prepared by addition of a dissolution of Zn(NO3)26H2O (14.85 mg, 0.049 mmol, 2 ml) into a <strong>[27148-03-4]thiosaccharine</strong> solution (20 mg, 0.1 mmol/ethanol:water 1:1,2 ml). A o-phenantroline solution was finally added drop by drop (ethanol:water 1:1, 2 ml) and a yellow power was obtained. The resulting yellow solid was filtered and washed with cold water. Crystals suitable for X-ray diffraction studies were produced by slow diffusion of diethyl ether to the mother solution. Yield: 74% Molar Conductivity (mS M1) = 22.4. Calculated analytical percent composition for C26H16N4O4S4Zn: C = 48.516%; H = 2.267%; N =8.592%; Found: C = 48.638%; H = 2.511%; N = 8.725%. Soluble indimethyl sulfoxide and dimethyl formamide. Non-soluble in other solvents (methanol, chloroform, dichloromethane, acetone, water). UV-Visible [DMSO, kmax nm]: 341. 1HNMR (300 MHz,DMSO) d 8.72-9.21 (m, 1H), 8.94 (m, 1H), 8.31(m, 1H), 8.03-8.21 (m, 1H), 7.91 (m, 1H), 7.57-7.72 (m, 3H). 13CNMR (75 MHz, DMSO) d 191.81 (C1), 149.09 (C8), 140.02 (C10), 139.36(C12), 137.94 (C7), 136.52 (C2), 132.12 (C4), 130.91 (C5), 128.70 (C11), 127.37 (C13), 125.10 (C3), 125.81 (C9), 119.03 (C6).

Reference： [1]Inorganica Chimica Acta,2018,vol. 479,p. 266 - 274

62
[ 27148-03-4 ]
zinc(II) nitrate hexahydrate [ No CAS ]
[ 17252-51-6 ]
[Zn(1,1-dioxo-1,2-benzisothiazole-3-thiolato)2(4,4'-trimethylenedipyridine)]n [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	In ethanol; water; at 20℃;	The complex was synthesized by addition of 4,4'-trimethylenedipyridine (6.2 mg, 0.031 mmol) and <strong>[27148-03-4]thiosaccharine</strong> (12.7 mg, 0.0638 mmol), respectively, to a solution of Zn(NO3)26H2O (10.2mg, 0.0342 mmol) in ethanol:water (4 ml), and kept under mechanical stirring at room temperature. The resulting yellow solid was filtered off and washed with cold water. By slow evaporation of the mother solution single crystals appeared. They were washed with water and analysed using X-ray diffraction. Yield: 82%. Molar conductivity (mS M1) = 28.3. Analytical percent composition calculated for C27H22N4O4S4Zn: C = 49.127%; H = 3.359%;N = 8.487%. Found: C = 48.811%; H = 2.981%; N = 8.378%. Soluble in DMSO and DMF. Slightly soluble in water, ethanol, methanol, chloroform. Insoluble in acetone and methane dichloride. UV-Visible [DMSO, kmax nm]: 347.1H NMR (300 MHz, DMSO) d 8.46 (dd, 4H), 7.92 (m, 2H), 7.58-7.72 (m, 6H), 7.28 (dd, 4H), 2.64 (t, 4H), 1.93 (m, 2H). 13C NMR (75 MHz, DMSO) d 191.71 (C1), 151.07 (C10), 149.31 (C8), 137.98(C7), 136.56 (C2), 132.05 (C4), 130.82 (C5), 125.07 (C3), 124.04(C9), 119.01 (C6), 33.80 (C11), 30.12 (C12).

Reference： [1]Inorganica Chimica Acta,2018,vol. 479,p. 266 - 274

63
[ 553-26-4 ]
[ 27148-03-4 ]
zinc(II) nitrate hexahydrate [ No CAS ]
[(4,4'-bipyridine)H2][Zn(1,1-dioxo-1,2-benzisothiazole-3-thiolato)4] [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
26.9%	In ethanol; water; at 20℃;	It was obtained by addition of 4,4'-bipyridine (7.7 mg, 0.049 mmol) and <strong>[27148-03-4]thiosaccharine</strong> (20.3 mg, 0.102 mmol), to a dissolution of Zn(NO3)26H2O (15.2 mg, 0.0511 mmol) in water/ethanol 1:1, with mechanical stirring at ambient temperature. The resulting yellow precipitate was washed with water and dried. Yellow crystals, suitable for X-ray diffraction studies were obtained. Yield: 26.9%. Molar Conductivity (mS M1) = 138.7.Analytical percent composition calculated for C38H26N6O8S8Zn:C = 44.901%; H = 2.580%; N = 8.270%. Found: C = 45.996%; H =2.473%; N = 8.446%.Soluble in dimethyl sulfoxide and dimethyl formamide. Slightly soluble in water, ethanol, methanol and chloroform. Insoluble in acetone and dichloromethane. UV-Visible [DMSO, kmax nm]: 340.1H NMR (300 MHz, DMSO) d 8.98 (dd, 4H), 8.30 (dd, 4H), 7.87-8.02 (m, 4H), 7.73-7.81 (m, 4H), 7.35-7.72 (m, 10H). 13C NMR (75MHz, DMSO) d 191.56 (C1), 148.94 (C8), 145.88 (C10), 137.88 (C7),136.35 (C2), 132.28 (C4), 131.11 (C5), 125.16 (C3), 122.38 (C9),119.15 (C6).

Reference： [1]Inorganica Chimica Acta,2018,vol. 479,p. 266 - 274

64
[ 366-18-7 ]
[ 27148-03-4 ]
zinc(II) nitrate hexahydrate [ No CAS ]
2C₇H₄NO₂S₂^(1-)*Zn⁽²⁺⁾*C₁₀H₈N₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%		General procedure: The [Zn(tsac)2(o-phen)] complex was prepared by addition of a dissolution of Zn(NO3)26H2O (14.85 mg, 0.049 mmol, 2 ml) into a <strong>[27148-03-4]thiosaccharine</strong> solution (20 mg, 0.1 mmol/ethanol:water 1:1,2 ml). A o-phenantroline solution was finally added drop by drop (ethanol:water 1:1, 2 ml) and a yellow power was obtained. The resulting yellow solid was filtered and washed with cold water. Crystals suitable for X-ray diffraction studies were produced by slow diffusion of diethyl ether to the mother solution. Yield: 74%

Reference： [1]Inorganica Chimica Acta,2018,vol. 479,p. 266 - 274

65
[ 27148-03-4 ]
bis[(benzyldimethylamino)chloropalladium(II)] [ No CAS ]
C₂₅H₂₈ClN₃O₂Pd₂S₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%	In methanol; chloroform; at 20℃; for 2h;	A solution of Htsac (0.035 g, 0.18 mmol) in MeOH was added toa solution of 1 (0.10 g, 0.18 mmol) in CHCl3 (10 cm3). The mixturewas stirred for 2 h and the resulting pale brown solid was collectedand dried in vacuum. Yield 0.116 g, 90%. Anal. Calc. for C25H28ClN3-O2Pd2S2: C, 42.0, H, 4.0, N, 5.9. Found: C, 42.2, H, 4.0, N, 5.7. Molarconductivity (DMSO): 0.30 (X-1 mol1 cm1). IR: 3083w, 2916w,1558 m, 1453vs, 1317 s, 1168 s, 1020 s, 815 s, 449w, 362 s cm1.1H NMR (DMSO d6): d 8.12-8.10 (dd, J 7.2, 1.2 2H, Ph), 7.97-7.95(m, 1H, Ph), 7.84-7.82 (m, 2H, Ph), 7.60 (d, J 7.2, 1H, Ph), 7.47 (d, J 7.2, 1H, Ph), 7.05-6.91 (m, 5H, Ph), 6.82 (d, J 7.2, 1H, Ph), 4.02(s, 4H, CH2), 2.72 (s, 12H, 4CH3). Mp: 202-204 C.

Reference： [1]Inorganica Chimica Acta,2018,vol. 479,p. 197 - 202

66
[ 27148-03-4 ]
C₁₆H₁₂N₂O₁₀Os₃ [ No CAS ]
C₁₇H₅NO₁₂Os₃S₂ [ No CAS ]
C₁₇H₅NO₁₂Os₃S₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%; 22%	In benzene; at 20℃; for 2h;Inert atmosphere; Schlenk technique;	Room temperature: To a benzene solution (20mL) containing [Os3(CO)10(NCMe)2] (0.13g, 0.14mmol) was added tsacH (56g, 0.28mmol), after which the solution was allowed to stir at room temperature for 2h. TLC examination of the reaction revealed the presence of two new products in a 3:1 ratio representing 1 and 2, respectively. The products were isolated by chromatography using an eluent composed of cyclohexane/ CH2Cl2 (1:1, v/v) that afforded two bands corresponding to [HOs3(CO)10(mu-N,S-1,3-tsac)] (2) (32mg, 22%) and [HOs3(CO)10(mu-S-tsac)] (1) (0.10g, 68%) in order of elution. Each product was obtained as orange crystals after recrystallization from n-hexane/CH2Cl2 at 4C. Data for 1: Anal. Calc. for C17H5NO12Os3S2: C, 19.44; H, 0.48, N, 1.33. Found: C, 19.92; H, 0.54, N, 1.36%. IR (nuCO, CH2Cl2): 211m, 2076vs, 2066s, 2028s, 2019s, 1992m cm-1. 1H NMR (CDCl3): delta 8.00 (m, 1H), 7.90 (m, 1H), 7.86 (m, 2H),-17.10 (s, 1H). Data for 2: Anal. Calc. for C17H5NO12Os3S2: C, 19.44; H, 0.48, N, 1.33. Found: C, 19.98; H, 0.52; N, 1.37%. IR (nuCO, CH2Cl2): 2113m, 2076s, 2065s, 2029s, 2018s, 1994w, 1982w cm-1. 1H NMR (CDCl3): delta 7.94 (d, J 7.2Hz, 1H), 7.84 (d, J 7.2Hz, 1H), 7.72 (m, 2H),-13.96 (s, 1H).

Reference： [1]Journal of Organometallic Chemistry,2019,vol. 880,p. 223 - 231

67
[ 27148-03-4 ]
[ 15243-33-1 ]
C₂₀H₈N₂O₁₀Ru₂S₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
12%	In dichloromethane; at 40℃; for 8h;Inert atmosphere; Schlenk technique;	A CH2Cl2 solution (20mL) of [Ru3(CO)12] (100mg, 0.16mmol) and tsacH (63mg, 0.32mmol) was heated to reflux for 8h during which time the color of the solution changed from yellow to deep red. The reaction mixture was then allowed to cool at room temperature, and the solvent was removed under reduced pressure. The residue was separated by TLC on silica gel using a binary eluent composed of n-hexane/CH2Cl2 (v/v, 1:1), yielding a single yellow band corresponding to [Ru2(CO)6(mu-N,S-tsac)2] (1). The product was recrystallized from n-hexane/CH2Cl2 at 4C and furnished orange crystals of analytically pure 1 in 12% yield (14mg). Data for 1: Anal. Calc. for C20H8N2O10Ru2S4: C, 31.33; H, 1.05; N, 3.65. Found: C, 31.64; H, 1.12; N, 3.69%. IR (nuCO, CH2Cl2): 2102s, 2075vs, 2032sh, 2027s, 1961w cm-1. 1H NMR (CDCl3): delta 8.01 (d, J 7.2Hz, 2H), 7.88 (d, J 7.2Hz, 2H), 7.78 (t, J 7.2Hz, 2H), 7.73 (t, J 7.2Hz, 2H).

Reference： [1]Journal of Organometallic Chemistry,2020,vol. 906

68
[ 27148-03-4 ]
[ 15243-33-1 ]
C₂₀H₈N₂O₁₀Ru₂S₄ [ No CAS ]
C₂₁H₁₀N₂O₁₁Ru₃S₄ [ No CAS ]
C₂₆H₈N₂O₁₆Ru₄S₅ [ No CAS ]
C₂₇H₁₀N₂O₁₇Ru₅S₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
4%; 17%; 7%; 11%	In tetrahydrofuran; at 66℃; for 4h;Inert atmosphere; Schlenk technique;	To a thf solution (20mL) of [Ru3(CO)12] (100mg, 0.16mmol) was added tsacH (63mg, 0.32mmol). The reaction mixture was heated to reflux for 4h, after which time the reaction mixture was then allowed to cool at room temperature. The solvent was removed under reduced pressure and the residue chromatographed by TLC on silica gel. Elution with n-hexane/CH2Cl2 (v/v, 1:1) developed four bands. The first band was unreacted [Ru3(CO)12] (14mg). The second band afforded [H2Ru3(CO)7(mu-N,S-tsac)(mu-C,N-C6H4CNSO2)(mu3-S)] (2) as orange crystals (24mg, 17%) after recrystallization from n-hexane/CH2Cl2 at 4C. The third band afforded two types of crystals (yellow and orange) after recrystallization from n-hexane/CH2Cl2 at 4C which were physically separated by hand. The orange crystals were characterized as [Ru2(CO)6(mu-N,S-tsac)2] (1) (7mg, 4%), while the yellow crystals were characterized as [Ru4(CO)12(mu-N,S-tsac)2(mu4-S)] (3) (10mg, 7%). The fourth band afforded [H2Ru5(CO)13(mu-N,S-tsac)(mu-C,N-C6H4CNSO2)(mu3-S)(mu4-S)] (4) (14mg, 11%) as orange crystals after recrystallization from n-hexane/CH2Cl2 at 4C. Data for 2: Anal. Calc. for C21H10N2O11Ru3S4: C, 28.10; H, 1.12; N, 3.12. Found: C, 28.32; H, 1.15, N, 3.14%. IR (nuCO, CH2Cl2): 2124vs, 2067vs, 2060sh, 2012s cm-1. 1H NMR (CDCl3): delta 8.29 (d, J 8.0Hz, 1H), 8.02 (m, 1H), 7.91 (t, J 7.2Hz, 1H), 7.85 (m, 1H), 7.82 (m, 1H), 7.78 (d, J 7.2Hz, 1H), 7.73 (m, 2H),-14.31 (d, J 0.8Hz, 1H),-16.14 (d, J 0.8Hz, 1H). Data for 3: Anal. Calc. for C26H8N2O16Ru4S5: C, 26.72; H, 0.69; N, 2.40. Found: C, 27.08; H, 0.74; N, 2.48%. IR (nuCO, CH2Cl2): 2124w, 2102s, 2087vs, 2066vs, 2021vs cm-1. 1H NMR (CD2Cl2): delta 8.06 (m, 1H), 7.99 (d, J 7.2Hz, 1H), 7.90-7.76 (m, 6H). Data for 4: Anal. Calc. for C27H10N2O17Ru5S5: C, 24.95; H, 0.78; N, 2.15. Found: C, 25.28; H, 0.85; N, 2.24%. IR (nuCO, CH2Cl2): 2124s, 2093s, 2066vs, 2041s, 2016s, 1958w cm-1. 1H NMR (CD2Cl2): aromatic region, major isomer, delta 8.13 (d, J 7.2Hz, 1H), 7.93-7.74 (m, 7H); hydride region, major isomer, delta-13.67 (d, J 2.0Hz, 1H),-15.55 (d, J 2.0Hz, 1H), minor isomer, delta-13.78 (d, J 2.0Hz, 1H),-16.07 (d, J 2.0Hz, 1H). Major/minor=21:1.

Reference： [1]Journal of Organometallic Chemistry,2020,vol. 906

69
[ 27148-03-4 ]
[ 15243-33-1 ]
C₂₂H₅NO₁₇Ru₅S₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
17%	In cyclohexane; at 81℃; for 0.5h;Inert atmosphere; Schlenk technique;	TsacH (63mg, 0.32mmol) was added to a cyclohexane solution (20mL) of [Ru3(CO)12] (100mg, 0.16mmol) and the reaction mixture was heated to reflux for 30min. The reaction mixture was then allowed to cool at room temperature. The solvent was removed under reduced pressure and the residue separated by TLC on silica gel. Elution with n-hexane/CH2Cl2 (v/v, 1:1) developed a yellow-orange band corresponding to [HRu5(CO)15(mu-N,S-tsac)(mu5-S)] (5). The product was recrystallized from n-hexane/CH2Cl2 at 4C to afford 5 as red crystals (18mg, 17%). Data for 5: Anal. Calc. for C22H5NO17Ru5S3: C, 22.84; H, 0.44; N, 1.21. Found: C, 23.14; H, 0.48; N, 1.23%. IR (nuCO, CH2Cl2): 2106w, 2083s, 2071vs, 2034s, 2014s, 1967w cm-1. 1H NMR (CDCl3): delta 7.88 (d, J 7.6Hz, 1H), 7.81 (t, J 7.6Hz, 1H), 7.72 (d, J 7.6Hz, 1H), 7.66 (t, 7.6Hz, 1H),-17.87 (s, 1H).

Reference： [1]Journal of Organometallic Chemistry,2020,vol. 906

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P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 27148-03-4 ] {[proInfo.proName]}

Quality Control of [ 27148-03-4 ]

Related Doc. of [ 27148-03-4 ]

Product Details of [ 27148-03-4 ]

Calculated chemistry of [ 27148-03-4 ]

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Lipophilicity

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Water Solubility

Medicinal Chemistry

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Application In Synthesis of [ 27148-03-4 ]

[ 27148-03-4 ] Synthesis Path-Upstream 1~2

[ 27148-03-4 ] Synthesis Path-Downstream 1~69

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Amides

Sulfamides

Precautionary Statements-General

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Physical hazards

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[ 27148-03-4 ]