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Chemical Structure| 270899-93-9 Chemical Structure| 270899-93-9

Structure of 270899-93-9

Chemical Structure| 270899-93-9

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Product Details of [ 270899-93-9 ]

CAS No. :270899-93-9
Formula : C6H5ClFNO
M.W : 161.56
SMILES Code : OC1=CC(N)=C(Cl)C=C1F
MDL No. :MFCD20701978

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Application In Synthesis of [ 270899-93-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 270899-93-9 ]

[ 270899-93-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 270899-93-9 ]
  • [ 22200-50-6 ]
  • [ 1062589-83-6 ]
YieldReaction ConditionsOperation in experiment
58% In butan-1-ol; at 120℃; for 17.0h; Intermediate 5 (1 g 3.46 mmol) and Intermediate 18 (0.562 g 3.4 mmol) were combined and heated in n-butanol (10 ml) at 120° C. for 17 h. Acetonitrile (100 ml) was added, and the solid was collected by filtration. The solids were washed with copious amounts of acetonitrile and air dried by suction filtration to yield the hydrochloride salt of the desired product (0.91 g, 58percent). The free base was formed by combining the product with chloroform and saturated potassium carbonate and the mixture was stirred at 75° C. for 50 minutes. The reaction mixture was allowed to cool to room temperature and the solids were collected by filtration. The solids were washed with CHCl3 and H2O, and dried by suction filtration to yield a pale yellow powder.
 

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