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Chemical Structure| 27038-48-8 Chemical Structure| 27038-48-8

Structure of 27038-48-8

Chemical Structure| 27038-48-8

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Product Details of [ 27038-48-8 ]

CAS No. :27038-48-8
Formula : C7H5NO2
M.W : 135.12
SMILES Code : O=C1COC2=NC=CC=C12
MDL No. :MFCD13190276

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Application In Synthesis of [ 27038-48-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 27038-48-8 ]

[ 27038-48-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 27038-48-8 ]
  • [ 144186-57-2 ]
YieldReaction ConditionsOperation in experiment
47.7% With methanol; sodium tetrahydroborate; at 0 - 20℃; for 3h; To a stirred solution of furo[2,3-b]pyridin-3(2H)-one (8 g, 59.2 mmol) in methanol (80 mL) was added NaBH4 (2.24 g, 59.2 mmol) at 0 C. Reaction mixture was stirred at RT for 3h. The reaction mixture was diluted with EtOAc (200 mL) washed with water (200 mL) and brine (200 mL). Organic layer was dried anhydrous sodium sulphate filtered and concentrated. Crude was purified by column chromatography (100-200 mesh silica gel) and the compound eluted at 80% EtOAc in hexane. Eluents were concentrated to affording 2,3-dihydrofuro[2,3-b]pyridin-3-ol (4 g, 47.7%) as off white solid. 1H NMR (500 MHz, DMSO -d6) d 8.06-8.05 (m, 1H), 7.77-7.75 (m, 1H), 6.95-6.92 (m, 1H), 5.77-5.76 (d, / = 6 Hz, 1H), 5.30-5.27 (m, 1H), 4.57-4.54 (m, 1H),4.24-4.21 (m, 1H). LCMS (ES) m/z 138.12 [M+H]+.
 

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