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Chemical Structure| 269741-35-7 Chemical Structure| 269741-35-7

Structure of 269741-35-7

Chemical Structure| 269741-35-7

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Product Details of [ 269741-35-7 ]

CAS No. :269741-35-7
Formula : C17H25NO3
M.W : 291.39
SMILES Code : O=C(N1CCC([C@@H](O)C2=CC=CC=C2)CC1)OC(C)(C)C

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Application In Synthesis of [ 269741-35-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 269741-35-7 ]

[ 269741-35-7 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 269741-35-7 ]
  • [ 193217-39-9 ]
YieldReaction ConditionsOperation in experiment
2.43 g To a slurry of tert-butyl 4-[hydroxy(phenyl)methyl]piperidine-1-carboxylate (2.73 g, 9.38 mmol) and NaHCO3(3.94 g, 46.9 mmol) in DCM (30 mL) at 0 C was added DMP (4.38 g, 10.32 mmol). After stirring for 21 h at rt, it was cooled to 0 C and more DMP (4.38 g, 10.3 mmol) was added. After 1.5 h, Na2SO3(1 M, 10 mL) was added and it was stirred for an additional 1 h, whereupon it was diluted with DCM/water and the layers were separated. The aqueous layer was extracted with DCM (3x), then the combined organic layers were washed with saturated NaHCO3, brine, dried over Na2SO4and concentrated in vacuo. The crude residue was purified via silica gel chromatography (ethyl acetate-heptane, 0-30%), affording the title compound (2.43 g, 89%, 2-steps) as a clear oil. LCMS (ES, m/z): 290.4 [M+H]+.
 

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