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Chemical Structure| 26413-58-1 Chemical Structure| 26413-58-1

Structure of 26413-58-1

Chemical Structure| 26413-58-1

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Product Details of [ 26413-58-1 ]

CAS No. :26413-58-1
Formula : C7H5Cl2NO
M.W : 190.03
SMILES Code : O=C(Cl)C1=CC(Cl)=NC(C)=C1
MDL No. :MFCD00052829

Safety of [ 26413-58-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:1760
Packing Group:

Application In Synthesis of [ 26413-58-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 26413-58-1 ]

[ 26413-58-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2339-58-4 ]
  • [ 26413-58-1 ]
  • ammonium thiocyanate [ No CAS ]
  • [ 1145355-37-8 ]
YieldReaction ConditionsOperation in experiment
73% Description 13 l-(2-Chloro-6-methyl-pyridine-4-carbonyl)-3-(3-fluoro-5-methoxy-phenyl)- thiourea (D13)2-Chloro-6-methyl-4-pyridinecarbonyl chloride (44.087 g, 0.232 mol) in acetone (1 1) was treated with ammonium isothiocyanate (21.192 g, 0.278 mol) and the mixture was stirred for 1 hour at room temperature. Subsequently, a solution of 3-fluoro-5- methoxybenzenamine (36.02 g, 0.255 mol) in acetone (200 ml) was added dropwise and the reaction mixture was stirred for 4 hours at room temperature. The solvent was evaporated in vacuo and the residue was dissolved in CH2Cl2 (1 1). This organic solution was washed (H2O), dried (MgSO4), filtered and the solvent was evaporated in vacuo to yield a brown solid. The brown solid was triturated in acetonitrile (0.8 1), stirred overnight and the solid was filtered off and dried (vacuum oven, 4 hours at 65 0C). Yield: 59.69 g of intermediate D13 (73 %).
 

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