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Chemical Structure| 263559-08-6 Chemical Structure| 263559-08-6

Structure of 263559-08-6

Chemical Structure| 263559-08-6

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Product Details of [ 263559-08-6 ]

CAS No. :263559-08-6
Formula : C14H11F3N2O
M.W : 280.25
SMILES Code : O=C(NC1=CC=C(C(F)(F)F)C=C1)C2=CC=CC=C2N
MDL No. :MFCD09811595

Safety of [ 263559-08-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 263559-08-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 263559-08-6 ]

[ 263559-08-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1039948-89-4 ]
  • [ 263559-08-6 ]
  • [ 1235479-89-6 ]
YieldReaction ConditionsOperation in experiment
55% With copper dichloride; In ethanol; for 16.0h;Reflux; Inert atmosphere; Example 11. Preparation of 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-3-(4- (trifluoromethyl)phenyl)quinazolin-4(3H)-one; [0171] To a solution of IH-benzoIcfHI .Sloxazine^-dione (1.63 g, 10.0 mmol) in anhydrous DMF (20 mL) was added 4-trifluoromethyl-aniline (1.61 g, 10.0 mmol) and the reaction mixture was stirred at 115C for 16 hours. It was then cooled to room temperature, diluted with ethyl acetate (150 mL), and the organic phase was washed with water (100 mL), 10% aq. NaOH solution (100 mL), water (150 mL), brine (150 mL), and dried over anhydrous Na2SO4. Solvent was evaporated and the crude compound was purified by the Simpliflash system (20% ethyl acetate in hexanes as eluent) to give 2-amino-Lambda/-(4-trifluoromethyl-phenyl)- benzamide as an off-white solid. Yield: 0.2 g (7%).[0172] To a solution of 2-amino-Lambda/-(4-trifluoromethyl-phenyl)-benzamide (0.19 g, 0.68 mmol) and <strong>[1039948-89-4]4-(2-hydroxy-ethoxy)-3,5-dimethyl-benzaldehyde</strong> (0.16 g, 0.81 mmol) in anhydrous ethanol (15 mL) was added anhydrous copper (II) chloride (0.273 g, 2.03 mmol). The reaction mixture was stirred at reflux for 16 hours under nitrogen and then cooled to room temperature. Ethanol was evaporated under reduced pressure. The residue was taken in ethyl acetate (100 ml_). The organic phase was washed with water (2 * 75 ml_), then brine (75 ml_), and dried over anhydrous Na2SO4. Solvent was evaporated; crude compound was purified by column chromatography (silica gel 230-400 mesh; 2:3:5 ethyl acetate, hexanes and CH2CI2 as eluent) to give the title compound as a white solid. Yield: 0.17 g (55%). MP 160-1610C. 1H-NMR (400 MHz, CDCI3): delta 8.34 (d, J = 8.00 Hz, 1 H), 7.84-7.82 (m, 2H), 7.62-7.53 (m, 3H), 7.31 (d, J = 8.40 Hz, 2H), 6.97 (s, 2H), 3.93-3.89 (m, 2H), 3.80 (t, J = 5.20 Hz, 2H), 2.15 (s, 6H), 2.07 (t, J = 6.40 Hz, 1 H).
 

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