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Chemical Structure| 25563-14-8 Chemical Structure| 25563-14-8

Structure of 25563-14-8

Chemical Structure| 25563-14-8

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Product Details of [ 25563-14-8 ]

CAS No. :25563-14-8
Formula : C8H8ClNO2
M.W : 185.61
SMILES Code : CONC(C1=CC=C(C=C1)Cl)=O
MDL No. :MFCD11225241

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Application In Synthesis of [ 25563-14-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 25563-14-8 ]

[ 25563-14-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 25563-14-8 ]
  • [ 79477-87-5 ]
  • 5-chloro-3-(3-fluorophenyl)-3-hydroxy-2-methoxyisoindolin-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% With ammonium peroxydisulfate; palladium diacetate; In tetrahydrofuran; at 20℃; for 3h;Sealed tube; Green chemistry; General procedure: A solution of benzamides (0.5 mmol), α-oxocarboxylic acids (0.6 mmol), Pd(OAc)2 (10 mol%) and(NH4)2S2O8 (4 mmol) in THF (3 mL) was stirred in a sealed tube under air at room temperature for 3 h.The reaction mixture was diluted with EtOAc and filtered through a pad of Celite. The filtrate waswashed with saturated aqueous Na2CO3 to remove the acid. The organic layer was dried over anhydrousNa2SO4 and filtered, and the solvent was removed under vacuum or in vacuo to provide the crude product.The purification was performed by flash column chromatography on silica gel (eluent: petroleumether/EtOAc = 4/1, v/v) to give 3-hydroxyisoindolin-1-ones.
 

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