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Chemical Structure| 255051-14-0 Chemical Structure| 255051-14-0
Chemical Structure| 255051-14-0

4-(2-(Trifluoromethyl)phenyl)piperidine hydrochloride

CAS No.: 255051-14-0

4.5 *For Research Use Only !

Cat. No.: A372674 Purity: 98%

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Product Details of [ 255051-14-0 ]

CAS No. :255051-14-0
Formula : C12H15ClF3N
M.W : 265.70
SMILES Code : Cl.FC(F)(F)C1=C(C=CC=C1)C1CCNCC1
MDL No. :MFCD02178914
InChI Key :BZYIRYKJNSACFP-UHFFFAOYSA-N
Pubchem ID :21936970

Safety of [ 255051-14-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 255051-14-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 255051-14-0 ]

[ 255051-14-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 255051-14-0 ]
  • [ 1077-96-9 ]
  • (5-fluoro-1H-indazol-3-yl)(4-(2-(trifluoromethyl)phenyl)piperidin-1-yl)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
51% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; General procedure: Example IS: Preparation of (5-M.uoro-lH-indazol-3~yl) (4- (2- hyl) henylpiperidin-1-yl)methanone Step A: Following general procedure GP-A2 , 4- (2- ( trifluoromethyl) phenyl) iperidine hydrochloride and 5~fluoro-lff- indazole-3-carboxylic acid were converted to (5-fluoro-lH-indazol-S- yl) (4- (2- ( trifluoromethyl) phenyl ) piperidin-l-yl ) methanone as a white solid (0.087 g, 51%) : mp 188-190 C; NMR (500 MHz, DMS0-d6) delta 13.64 (s, 1H) , 7.73-7.59 (m, 5H) , 7.45-7.39 (m, 1H) , 7.36-7.29 (m, 1H) , 5.08-4.99 (m, 1H) , 4.83-4.74 (m, 1H) , 3.29-3.13 (m, 2H) , 2.95-2.85 (m, 1H), 1.86-1.71 (m, 4H) ; ESI MS m/z 392 [M + H]*.
 

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