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Chemical Structure| 2538-87-6 Chemical Structure| 2538-87-6

Structure of 2538-87-6

Chemical Structure| 2538-87-6

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Product Details of [ 2538-87-6 ]

CAS No. :2538-87-6
Formula : C9H8O2
M.W : 148.16
SMILES Code : O=C/C=C/C1=CC=C(O)C=C1
MDL No. :MFCD00599378
InChI Key :CJXMVKYNVIGQBS-OWOJBTEDSA-N
Pubchem ID :641301

Safety of [ 2538-87-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 2538-87-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2538-87-6 ]

[ 2538-87-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1080-12-2 ]
  • [ 2538-87-6 ]
  • [ 1612860-92-0 ]
YieldReaction ConditionsOperation in experiment
20% With sodium hydroxide; In ethanol; water; at 0 - 20℃; General procedure: To a solution of each of substituted 4-phenylbut-3-en-2-ones(7a1-d1, 7e, 7f and 7c3) and substituted 3-phenylacrylaldehydes (8a1-d1, 8c3 and 8a2-b2) in ethanol was added 20% (w/v) aqueous NaOH at 0-5 C. The mixture was allowed to stir at ambient temperature until the starting material was consumed, during which time the progress of the reaction was monitored by TLC. Development of dark orange coloration indicated that the reaction has taken place. Ethanol was removed in vacuo; ice-water was added to the residue and the solution was neutralized with cold 3M HCl (or acidified to pH ca. 1-2 in the case of 4 and 5, the intermediates 3-phenylacrylaldehydes 8a2 and 8b2 were used, respectively). The solid was collected by vacuum filtration (or extracted with EtOAc and the solvent was evaporated to dryness), washed with water and dried. The residue was purified by column chromatography or recrystallized from appropriate solvent system to provide the substituted trienone analogues 4, 5, 9-15 and 17-20.
 

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Technical Information

• Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Corey-Fuchs Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • Grignard Reaction • Hantzsch Dihydropyridine Synthesis • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Julia-Kocienski Olefination • Knoevenagel Condensation • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mukaiyama Aldol Reaction • Nozaki-Hiyama-Kishi Reaction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stetter Reaction • Stobbe Condensation • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

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