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Chemical Structure| 25084-14-4 Chemical Structure| 25084-14-4

Structure of 25084-14-4

Chemical Structure| 25084-14-4

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Product Details of [ 25084-14-4 ]

CAS No. :25084-14-4
Formula : C5H2ClNO4
M.W : 175.53
SMILES Code : O=C(Cl)C1=CC=C([N+]([O-])=O)O1
MDL No. :MFCD00039564

Safety of [ 25084-14-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 25084-14-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 25084-14-4 ]

[ 25084-14-4 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 25084-14-4 ]
  • [ 6973-09-7 ]
  • 5-Nitro-furan-2-carboxylic acid (4-methyl-3-sulfamoyl-phenyl)-amide [ No CAS ]
  • 2
  • [ 852180-47-3 ]
  • [ 25084-14-4 ]
  • [ 831203-79-3 ]
  • 3
  • [ 25084-14-4 ]
  • [ 35364-79-5 ]
  • [ 1419943-28-4 ]
  • 4
  • [ 25084-14-4 ]
  • [ 306761-54-6 ]
  • 5-nitro-N-(2-(4-(trifluoromethyl)phenyl)propan-2-yl)furan-2-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In dichloromethane; at 20℃;Inert atmosphere; General procedure: Step B The crude from above (0.16 g, 0.97 mmol) was dissolved in dry DCM (5 mL) and a solution of 5-nitro-2-furoyl chloride (0.17 g, 0.97 mmol) in dry DCM (5 mL) was added dropwise, followed by dropwise addition of Et3N (0.27 mL, 1.9 mmol) at room temperature. The crude reaction was stirred at room temperature until reaction completion, diluted with DCM (10 mL), and washed with saturated aqueous brine solution (15 mL). The organic layer was separated, dried over anhydrous Na2SO4, filtered, and concentrated in vacuo. Product was purified by column chromatography (95% DCM: 5% MeOH).
  • 5
  • [ 25084-14-4 ]
  • [ 33322-60-0 ]
  • N-(3-(dimethylcarbamoyl)phenyl)-5-nitrofuran-2-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
56% General procedure: Suspend p-nitrobenzoic acid (3-1a, 167mg, 1mmol) in dichloromethane (5mL), add 2 drops of DMF, and cool to 0C in an ice water bath.Slowly add oxalyl chloride (190 mg, 0.13 mL, 1.5 mmol) dropwise, and then stir at room temperature for 2 hours.The reaction solution is concentrated to remove the solvent and excess oxalyl chloride to obtain p-nitrobenzoyl chloride (3-2a),Without purification, tetrahydrofuran (1 mL) was added for use.Dissolve p-acetaminoaniline (3-3a, 150mg, 1mmol) in tetrahydrofuran (5mL),After adding triethylamine (152mg, 1.5mmol), the tetrahydrofuran solution of the above acid chloride 3-2a was added dropwise under ice bath.After dripping, it was reacted at room temperature until TLC (CH2Cl2:MeOH=15:1) showed that the reaction was complete.Add 30 mL of water to the reaction system, continue to stir for 10 minutes, and then filter with suction.The filter cake was washed successively with 5% hydrochloric acid and 10 mL of distilled water, and a yellow solid was obtained after drying.The yield is 80%, and the melting point is 301-303C (literature value [93] 293C (decomposition)).
  • 6
  • [ 580-15-4 ]
  • [ 25084-14-4 ]
  • N-(quinolin-6-yl)-5-nitrofuran-2-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
42% General procedure: Suspend p-nitrobenzoic acid (3-1a, 167mg, 1mmol) in dichloromethane (5mL), add 2 drops of DMF, and cool to 0C in an ice water bath.Slowly add oxalyl chloride (190 mg, 0.13 mL, 1.5 mmol) dropwise, and then stir at room temperature for 2 hours.The reaction solution is concentrated to remove the solvent and excess oxalyl chloride to obtain p-nitrobenzoyl chloride (3-2a),Without purification, tetrahydrofuran (1 mL) was added for use.Dissolve p-acetaminoaniline (3-3a, 150mg, 1mmol) in tetrahydrofuran (5mL),After adding triethylamine (152mg, 1.5mmol), the tetrahydrofuran solution of the above acid chloride 3-2a was added dropwise under ice bath.After dripping, it was reacted at room temperature until TLC (CH2Cl2:MeOH=15:1) showed that the reaction was complete.Add 30 mL of water to the reaction system, continue to stir for 10 minutes, and then filter with suction.The filter cake was washed successively with 5% hydrochloric acid and 10 mL of distilled water, and a yellow solid was obtained after drying.The yield is 80%, and the melting point is 301-303C (literature value [93] 293C (decomposition)).
 

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