Home Cart Sign in  
Chemical Structure| 25063-46-1 Chemical Structure| 25063-46-1

Structure of 25063-46-1

Chemical Structure| 25063-46-1

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 25063-46-1 ]

CAS No. :25063-46-1
Formula : C13H12ClNO4
M.W : 281.69
SMILES Code : O=C(/C1=C/NC2=CC=C(Cl)C=C2)OC(C)(C)OC1=O
MDL No. :MFCD01111608

Safety of [ 25063-46-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 25063-46-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 25063-46-1 ]

[ 25063-46-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 25063-46-1 ]
  • [ 23432-43-1 ]
YieldReaction ConditionsOperation in experiment
55% In diphenylether; at 240℃; for 0.5h;Heating / reflux; A mixture of 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid, 21.62 g, 0.15 mol) and trimethyl orthoformate (150 mL) was heated to a gentle reflux under nitrogen for 1 hour. The resulting red solution was cooled (80 C.) and 4-chloroaniline (19.14 g, 0.15 mol) was added portionwise resulting in the formation of a yellow solid. The reaction mixture was heated to reflux, stirred vigorously for an additional hour, and then cooled to 25 C. (see Ryan et al. (2006) Org. Lett. 8:2779-2782; Madrid et al. (2005) Bioorg. Med. Chem. Lett. 15:1015-1018). The resulting solid was filtered and washed with cold acetone to afford the ene-amine compound (29.58 g, 70%, mp. 214-214.5 C. (dec.)) as yellow solid which was characterized by 1H NMR. To a solution diphenyl ether (20 mL) at 240 C. was added the ene-amine compound (5 g, 17.75 mmol) in small portions resulting in vigorous gas evolution and the reaction was bought to reflux for 30 minutes under nitrogen. The reaction mixture was allowed to cool to 80 C. and the precipitate was isolated by filtration and washing with acetone and hexane until the filtrate was colorless. The brown solid was purified by digestion with ether followed by distillation under reduced pressure to give 6-chloroquinolin-4-ol as light-yellow solid in 55% yield (1.7533 g, m.p. 281-282.5 C. (see Riegel et al., (1946) J. Am. Chem. Soc. 68:1264-1266, m.p. 274-275 C.). 1H NMR (400 MHz, CDCl3): 6.07 (1H, d, J=7.4 Hz), 7.59 (1H, d, J=8.8 Hz), 7.68 (1H, dd, J=8.8, 2.5 Hz), 7.95 (1H, d, J=7.4 Hz), 8.01 (1H, d, J=2.4 Hz), 11.92 (1H, bs).
 

Historical Records

Technical Information

Categories