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Chemical Structure| 24634-02-4 Chemical Structure| 24634-02-4

Structure of 24634-02-4

Chemical Structure| 24634-02-4

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Product Details of [ 24634-02-4 ]

CAS No. :24634-02-4
Formula : C10H8ClNO2
M.W : 209.63
SMILES Code : O=C1NC(Cl)=CC2=C1C=CC=C2OC
MDL No. :MFCD24579395

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Application In Synthesis of [ 24634-02-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 24634-02-4 ]

[ 24634-02-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24634-02-4 ]
  • [ 940284-98-0 ]
  • 4-[5-(5-methoxy-1-oxo-1,2-dihydro-isoquinolin-3-yl)-pyrimidin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
100% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; at 120℃; for 2h;Inert atmosphere; Microwave irradiation; 3-Chloro-5-methoxy-2H-isoquinolin-1-one (100 mg, 0.48 mmol), 2-(4-Boc-piperazin-1- yl)pyrimidine-5-boronic acid pinacol ester (280 mg, 0.72 mmol), K2003 (132 mg, 0.96mmol) and Pd(dppf)C12 (1:1 complex with CH2CI2) (36 mg, 0.044 mmol) in DME/EtOH/H20 4:1:1 (2.5 mL) were added to a microwave vial and the reaction mixture purged with N2 for 10 mm. The reaction mixture was irradiated using a microwave reactor (300W, 120 00, 120 mm). The reaction mixture was concentrated in vacuo passed through a thiol cartridge (Silylcycle ig, 6 mL) eluting with CH2CI2, followed by MeOH. Theorganic fractions were concentrated in vacuo to afford 4-[5-(5-methoxy-1-oxo-1,2-dihydro- isoquinolin-3-yl)-pyrimidin-2-yl]-piperazine- 1 -carboxylic acid tert-butyl ester as a brown solid (210 mg, quant.) which was used in the next step without further purification.AnalpH2_MeOH_4min(1): Rt 3.28 mm; mlz 438 [M+1].
 

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