[ CAS No. 24630-67-9 ] {[proInfo.proName]}

Name: 24630-67-9|Dimethyl (hydroxymethyl)phosphonate|91%
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SKU: A320317
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3d Animation Molecule Structure of 24630-67-9

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Quality Control of [ 24630-67-9 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 24630-67-9 ]

SDS Specification

Alternatived Products of [ 24630-67-9 ]

Product Details of [ 24630-67-9 ]

CAS No. :	24630-67-9	MDL No. :	MFCD11053766
Formula :	C₃H₉O₄P	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	OIERWUPLBOKSRB-UHFFFAOYSA-N
M.W :	140.08	Pubchem ID :	11051732
Synonyms :

Calculated chemistry of [ 24630-67-9 ]

Physicochemical Properties

Num. heavy atoms :	8
Num. arom. heavy atoms :	0
Fraction Csp3 :	1.0
Num. rotatable bonds :	3
Num. H-bond acceptors :	4.0
Num. H-bond donors :	1.0
Molar Refractivity :	28.53
TPSA :	65.57 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-7.94 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.19
Log Po/w (XLOGP3) :	-1.11
Log Po/w (WLOGP) :	0.42
Log Po/w (MLOGP) :	-1.29
Log Po/w (SILICOS-IT) :	-0.91
Consensus Log Po/w :	-0.34

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	0.19
Solubility :	216.0 mg/ml ; 1.54 mol/l
Class :	Highly soluble
Log S (Ali) :	0.22
Solubility :	234.0 mg/ml ; 1.67 mol/l
Class :	Highly soluble
Log S (SILICOS-IT) :	0.04
Solubility :	155.0 mg/ml ; 1.11 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	4.26

Safety of [ 24630-67-9 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 24630-67-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 24630-67-9 ]
Downstream synthetic route of [ 24630-67-9 ]

[ 24630-67-9 ] Synthesis Path-Upstream 1~10

1
[ 50-00-0 ]
[ 868-85-9 ]
[ 24630-67-9 ]

Yield	Reaction Conditions	Operation in experiment
62%	at 100℃; for 2.5 h;	A stirred mixture of dimethylphosphite (10.0 ml, 109 mniol), triethylamine (1.5 ml, 10.9 mmol) and paraformaldehyde (3.26 g) was heated in an oil bath at 100 °C (external temperature). After 2.5 hours the mixture was cooled to room temperature, concentrated in vacua and the residue was purified by flash column chromatography (eluent: ethyl acetate/methanol 95:5) to provide the title compound as a colourless oil (9.41 g, 62percent).'H NMR (400 MHz, CDC1₃) 5 ppm 4.32 (1H, br s), 3.95 (2H, d, J6 Hz), 3.83 (3H, s) and 3.81 (3H,s).³¹P{¹H} NMR (400.1 MHz, CDC1₃) 5 ppm 27.8.¹³C NMR (100.6 MHz, CDC1₃) 8 ppm 53.5, 56.0 and 57.6.

Reference： [1] Journal of Polymer Science, Part A: Polymer Chemistry, 2012, vol. 50, # 12, p. 2432 - 2443
[2] Chemistry - A European Journal, 2009, vol. 15, # 9, p. 2064 - 2070
[3] Patent: WO2006/20779, 2006, A2, . Location in patent: Page/Page column 77
[4] Organic Letters, 2012, vol. 14, # 18, p. 4798 - 4801
[5] Bioorganic and Medicinal Chemistry, 1998, vol. 6, # 3, p. 315 - 322
[6] Phosphorus, Sulfur and Silicon and Related Elements, 1999, vol. 144-146, p. 633 - 636
[7] Phosphorus, Sulfur and Silicon and Related Elements, 2002, vol. 177, # 5, p. 1137 - 1145
[8] Journal of the American Chemical Society, 2006, vol. 128, # 3, p. 885 - 897
[9] Patent: US2008/207563, 2008, A1, . Location in patent: Page/Page column 23
[10] Phosphorus, Sulfur and Silicon and the Related Elements, 2009, vol. 184, # 11, p. 2777 - 2785
[11] Phosphorus, Sulfur and Silicon and the Related Elements, 2012, vol. 187, # 1, p. 135 - 141
[12] Journal of Polymer Science, Part A: Polymer Chemistry, 2011, vol. 49, # 18, p. 3905 - 3910
[13] Phosphorus, Sulfur and Silicon and the Related Elements, 2014, vol. 189, # 6, p. 812 - 818
[14] Patent: CN103980315, 2016, B, . Location in patent: Paragraph 0044-0046

2
[ 50-00-0 ]
[ 96-36-6 ]
[ 24630-67-9 ]

Reference： [1] J. Gen. Chem. USSR (Engl. Transl.), 1988, vol. 58, # 5, p. 1032[2] Zhurnal Obshchei Khimii, 1988, vol. 58, # 5, p. 1160
[3] Patent: US2007/197617, 2007, A1, . Location in patent: Page/Page column 24

3
[ 868-85-9 ]
[ 24630-67-9 ]

Reference： [1] Patent: US2006/41146, 2006, A1, . Location in patent: Page/Page column 27

4
[ 50-00-0 ]
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[ 24630-67-9 ]

Reference： [1] Tetrahedron Letters, 2009, vol. 50, # 49, p. 6745 - 6747

5
[ 24630-57-7 ]
[ 24630-67-9 ]

Reference： [1] Collection of Czechoslovak Chemical Communications, 1982, vol. 47, # 12, p. 3447 - 3463

6
[ 69412-44-8 ]
[ 76-05-1 ]
[ 24630-67-9 ]

Reference： [1] J. Gen. Chem. USSR (Engl. Transl.), 1982, vol. 52, # 12, p. 2385 - 2394[2] Zhurnal Obshchei Khimii, 1982, vol. 52, # 12, p. 2704 - 2715

7
[ 50-00-0 ]
[ 121-45-9 ]
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Reference： [1] Organic Letters, 2006, vol. 8, # 13, p. 2811 - 2813

8
[ 868-85-9 ]
[ 24630-67-9 ]
[ 65886-96-6 ]
[ 13590-71-1 ]

Reference： [1] J. Gen. Chem. USSR (Engl. Transl.), 1988, vol. 58, # 10, p. 1992 - 1996[2] Zhurnal Obshchei Khimii, 1988, vol. 58, # 10, p. 2238 - 2242

9
[ 756-79-6 ]
[ 1066-53-1 ]
[ 24630-67-9 ]

Reference： [1] New Journal of Chemistry, 2002, vol. 26, # 6, p. 732 - 744

10
[ 868-85-9 ]
[ 24630-67-9 ]
[ 65886-96-6 ]
[ 13590-71-1 ]

Reference： [1] J. Gen. Chem. USSR (Engl. Transl.), 1988, vol. 58, # 10, p. 1992 - 1996[2] Zhurnal Obshchei Khimii, 1988, vol. 58, # 10, p. 2238 - 2242

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P230	Keep wetted
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P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
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P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
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P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
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P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
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P330	Rinse mouth.
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P335	Brush off loose particles from skin.
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P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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Yield	Reaction Conditions	Operation in experiment
83%	With 2,6-dimethylpyridine; In dichloromethane; at -50 - 0℃; for 1.5h;	Trifluoromethanesulfonic anhydride (4.7 ml, 27.8 mmol) was added in a dropwise manner to a stirred solution of dimethy phosphonic ester alcohol (3.54 g, 25.3 mmol) and 2,6-lutidene (3.5 ml, 30.3 mmol) in dichloromethane (30 ml) ensuring that the internal temperature remained below -50 C. Once the addition was complete the mixture was slowly warmed to 0 C over approximately 90 minutes. Diethyl ether (150 ml) was then added and the resultant suspension was filtered through celite andwashed with diethyl ether (20 ml). The solution was then sequentially washed with water (90 ml), 1M hydrochloric acid (90 ml) and brine (90 ml). After drying (NaaSC^), filtration followed by concentration provided the title compound as a light yellow oil (5.67 g, 83%) which was used without further purification.'H NMR (400 MHz, CDC13) 8 ppm 4.87 (2H5 d, J9 Hz), 3.91 (3H, s) and 3.89 (3H, s)19F{.H} NMR (376.5 MHz, CDC13) 8 ppm -74.531P{JH} NMR (400.1 MHz, CDC13) 8 ppm 16.1
53%	With pyridine; In dichloromethane; at -20 - 0℃; for 0.5h;	(2) To a solution of <strong>[24630-67-9]hydroxymethyl-phosphonic acid dimethyl ester</strong> (2.0 g, 14.5 mmol) in anhydrous dichloromethane (50 mL) at -20 C. was added pyridine (1.4 mL, 16.7 mmol) followed by trifluoromethanesulfonic anhydride (2.7 mL, 15.9 mmol). After stirring at 0 C. for 0.5 hours, the mixture was filtered through celite with a thin layer of silica gel. The filtrate was washed with cold 1.0 N aqueous hydrochloric acid, water, saturated aqueous sodium bicarbonate and dried over sodium sulfate. The solvents were removed to give trifluoro-methanesulfonic acid dimethoxy-phosphorylmethyl ester as an oil (2.1 g, 53%).
	In dichloromethane; at -78 - 20℃; for 1h;	A solution of dimethoxyphosphorylmethanol (1 g) in dichloromethane (20 mL) was cooled to -78C and 2,6-Lutidine (1.32 mL) followed by trifluoromethylsulfonyl trifluoromethanesulfonate (1.91g) was added. The resulting reaction mixture was allowed to warm to room temperature and stirred for 1 hour. The reaction mixture was poured into water and extracted with dichloromethane (50 mL). The organic layer was washed with 1 M aqueous hydrochloric acid (50 mL), dried over anhydrous sodium sulfate and concentrated to give dimethoxyphosphorylmethyl trifluoromethanesulfonate as a pale yellow liquid. 1 H NMR (400 MHz, de-DMSO) 4.82 (d, 2H) 3.78 (s, 3H) 3.74 (s, 3H)

Yield	Reaction Conditions	Operation in experiment
62%	With triethylamine; at 100℃; for 2.5h;	A stirred mixture of dimethylphosphite (10.0 ml, 109 mniol), triethylamine (1.5 ml, 10.9 mmol) and paraformaldehyde (3.26 g) was heated in an oil bath at 100 C (external temperature). After 2.5 hours the mixture was cooled to room temperature, concentrated in vacua and the residue was purified by flash column chromatography (eluent: ethyl acetate/methanol 95:5) to provide the title compound as a colourless oil (9.41 g, 62%).'H NMR (400 MHz, CDC13) 5 ppm 4.32 (1H, br s), 3.95 (2H, d, J6 Hz), 3.83 (3H, s) and 3.81 (3H,s).31P{1H} NMR (400.1 MHz, CDC13) 5 ppm 27.8.13C NMR (100.6 MHz, CDC13) 8 ppm 53.5, 56.0 and 57.6.
	With triethylamine; at 70℃; for 1h;	Dimethyl phosphite (2.0 g, 18.2 mmol), paraformaldehyde (574 mg, 19.1 mmol) and triethylamine (0.25 mL, 1.8 mmol) were combined and heated to 70 C. to give a clear solution. After 1 hour the reaction was cooled and concentrated in vacuo overnight to afford the crude hydroxymethyl-phosphonic acid dimethyl ester (2.5 g).
	With potassium carbonate; In methanol; at 0 - 20℃; for 1h;	In the first step, 1.75 g (55 mmol) of paraformaldehyde was dissolved in 50 mL of methanol, 0.63 g (4.54 mmol) of potassium carbonate was added and the solution was cooled to 0 C. 5.0 g (45.4 mmol) of phosphorous acid And the temperature was raised to room temperature. After 1 h, the potassium carbonate was filtered off and the filtrate was removed under reduced pressure to give a colorless oil as Intermediate I;

Yield	Reaction Conditions	Operation in experiment
53%	With pyridine; In dichloromethane; at -20 - 0℃; for 0.5h;	To a solution of <strong>[24630-67-9]hydroxymethyl-phosphonic acid dimethyl ester</strong> (2.0 g, 14.5 mmol) in anhydrous dichloromethane (50 mL) at -20 C. was added pyridine (1.4 mL, 16.7 mmol) followed by trifluoromethanesulfonic anhydride (2.7 mL, 15.9 mmol). After stirring at 0 C. for 0.5 hours, the mixture was filtered through celite with a thin layer of silica gel. The filtrate was washed with cold 1.0 N aqueous hydrochloric acid, water, saturated aqueous sodium bicarbonate and dried over sodium sulfate. The solvents were removed to give trifluoro-methanesulfonic acid dimethoxy-phosphorylmethyl ester as an oil (2.1 g, 53%).
53%		(2) To a solution of <strong>[24630-67-9]hydroxymethyl-phosphonic acid dimethyl ester</strong> (2.0 g, 14.5 mmol) in anhydrous dichloromethane (50 mL) at -20 C. was added pyridine (1.4 mL, 16.7 mmol) followed by trifluoromethanesulfonic anhydride (2.7 mL, 15.9 mmol). After stirring at 0 C. for 0.5 hours, the mixture was filtered through celite with a thin layer of silica gel. The filtrate was washed with cold 1.0 N aqueous hydrochloric acid, water, saturated aqueous sodium bicarbonate and dried over sodium sulfate. The solvents were removed to give trifluoro-methanesulfonic acid dimethoxy-phosphorylmethyl ester as an oil (2.1 g, 53%).

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 24630-67-9 ] {[proInfo.proName]}

Quality Control of [ 24630-67-9 ]

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Product Details of [ 24630-67-9 ]

Calculated chemistry of [ 24630-67-9 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 24630-67-9 ]

Application In Synthesis of [ 24630-67-9 ]

[ 24630-67-9 ] Synthesis Path-Upstream 1~10

[ 24630-67-9 ] Synthesis Path-Downstream 1~70

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

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