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Chemical Structure| 24603-63-2 Chemical Structure| 24603-63-2

Structure of 24603-63-2

Chemical Structure| 24603-63-2

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Product Details of [ 24603-63-2 ]

CAS No. :24603-63-2
Formula : C7H4ClNO2
M.W : 169.57
SMILES Code : OC1=NOC2=C1C=C(Cl)C=C2
MDL No. :MFCD00125031

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Application In Synthesis of [ 24603-63-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 24603-63-2 ]

[ 24603-63-2 ] Synthesis Path-Downstream   1~3

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  • [ 16263-53-9 ]
  • [ 24603-63-2 ]
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  • [ 24603-63-2 ]
  • [ 16263-53-9 ]
YieldReaction ConditionsOperation in experiment
92% With pyridine; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; trichlorophosphate; EXAMPLE 16 3,5-Dichloro-1,2-benzisoxazole To a suspension of 5-chloro-3-hydroxy-1,2-benzisoxazole (100 g) in phosphorus oxychloride (80 ml) was added pyridine (48 ml) dropwise over 1 hours with stirring at room temperature, and the mixture was then refluxed for 5 hours. The reaction mixture was added to ice water (500 ml) and extracted with ethyl acetate and the combined extracts were dried over anhydrous magnesium sulphate. The solvent was evaporated under reduced pressure and the title compound (102 g, 92%) was obtained by recrystallizng the residue from petroleum ether as a colorless needle. Melting point: 43-44 C.; IR spectrum(KBr)numax cm-1: 1468, 1419, 1285; NMR spectrum(CDCl3)deltappm: 7.59(2H,d,J=1.5 Hz), 7.70(1H,brs).
  • 3
  • [ 24603-63-2 ]
  • [ 16263-53-9 ]
 

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