24410-61-5|7-Fluorobenzofuran| Ambeed

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Quality Control of [ 24410-61-5 ] Purity: 97% SDS Specification

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Product Details of [ 24410-61-5 ]

CAS No. :	24410-61-5
Formula :	C₈H₅FO
M.W :	136.12
SMILES Code :	FC1=C(OC=C2)C2=CC=C1
MDL No. :	MFCD15143817
InChI Key :	WPCSQSMSSNPKKB-UHFFFAOYSA-N
Pubchem ID :	15158726

Safety of [ 24410-61-5 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H317-H319
Precautionary Statements:	P280-P305+P351+P338

Computational Chemistry of [ 24410-61-5 ] Show Less

Physicochemical Properties

Num. heavy atoms	10
Num. arom. heavy atoms	9
Fraction Csp3	0.0
Num. rotatable bonds	0
Num. H-bond acceptors	2.0
Num. H-bond donors	0.0
Molar Refractivity	36.17
TPSA ? Topological Polar Surface Area: Calculated from Ertl P. et al. 2000 J. Med. Chem.	13.14 Å²

Lipophilicity

Log P_o/w (iLOGP)? iLOGP: in-house physics-based method implemented from Daina A et al. 2014 J. Chem. Inf. Model.	1.95
Log P_o/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry	2.43
Log P_o/w (WLOGP)? WLOGP: Atomistic method implemented from Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.	2.99
Log P_o/w (MLOGP)? MLOGP: Topological method implemented from Moriguchi I. et al. 1992 Chem. Pharm. Bull. Moriguchi I. et al. 1994 Chem. Pharm. Bull. Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.	2.0
Log P_o/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	2.87
Consensus Log P_o/w? Consensus Log P_o/w: Average of all five predictions	2.45

Water Solubility

Log S (ESOL):? ESOL: Topological method implemented from Delaney JS. 2004 J. Chem. Inf. Model.	-2.88
Solubility	0.179 mg/ml ; 0.00132 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble
Log S (Ali)? Ali: Topological method implemented from Ali J. et al. 2012 J. Chem. Inf. Model.	-2.35
Solubility	0.61 mg/ml ; 0.00448 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-3.53
Solubility	0.0398 mg/ml ; 0.000292 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble

Pharmacokinetics

GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg	High
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg	Yes
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) and tested on 415 molecules (test set) 10-fold CV: ACC=0.72 / AUC=0.77 External: ACC=0.88 / AUC=0.94	No
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.83 / AUC=0.90 External: ACC=0.84 / AUC=0.91	Yes
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.80 / AUC=0.86 External: ACC=0.80 / AUC=0.87	No
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) and tested on 2075 molecules (test set) 10-fold CV: ACC=0.78 / AUC=0.85 External: ACC=0.71 / AUC=0.81	No
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) and tested on 1068 molecules (test set) 10-fold CV: ACC=0.79 / AUC=0.85 External: ACC=0.81 / AUC=0.87	No
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) and tested on 2579 molecules (test set) 10-fold CV: ACC=0.77 / AUC=0.85 External: ACC=0.78 / AUC=0.86	No
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from Potts RO and Guy RH. 1992 Pharm. Res.	-5.41 cm/s

Druglikeness

Lipinski? Lipinski (Pfizer) filter: implemented from Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev. MW ≤ 500 MLOGP ≤ 4.15 N or O ≤ 10 NH or OH ≤ 5	0.0
Ghose? Ghose filter: implemented from Ghose AK. et al. 1999 J. Comb. Chem. 160 ≤ MW ≤ 480 -0.4 ≤ WLOGP ≤ 5.6 40 ≤ MR ≤ 130 20 ≤ atoms ≤ 70	None
Veber? Veber (GSK) filter: implemented from Veber DF. et al. 2002 J. Med. Chem. Rotatable bonds ≤ 10 TPSA ≤ 140	0.0
Egan? Egan (Pharmacia) filter: implemented from Egan WJ. et al. 2000 J. Med. Chem. WLOGP ≤ 5.88 TPSA ≤ 131.6	0.0
Muegge? Muegge (Bayer) filter: implemented from Muegge I. et al. 2001 J. Med. Chem. 200 ≤ MW ≤ 600 -2 ≤ XLOGP ≤ 5 TPSA ≤ 150 Num. rings ≤ 7 Num. carbon > 4 Num. heteroatoms > 1 Num. rotatable bonds ≤ 15 H-bond acc. ≤ 10 H-bond don. ≤ 5	2.0
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat implemented from Martin YC. 2005 J. Med. Chem.	0.55

Medicinal Chemistry

PAINS? Pan Assay Interference Structures: implemented from Baell JB. & Holloway GA. 2010 J. Med. Chem.	0.0 alert
Brenk? Structural Alert: implemented from Brenk R. et al. 2008 ChemMedChem	0.0 alert: heavy_metal
Leadlikeness? Leadlikeness: implemented from Teague SJ. 1999 Angew. Chem. Int. Ed. 250 ≤ MW ≤ 350 XLOGP ≤ 3.5 Num. rotatable bonds ≤ 7	No; 1 violation:MW<1.0
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties, trained on 12'782'590 molecules and tested on 40 external molecules (r² = 0.94)	2.18

Application In Synthesis of [ 24410-61-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 24410-61-5 ]

[ 24410-61-5 ] Synthesis Path-Downstream 1~29

2
[ 877263-51-9 ]
[ 24410-61-5 ]

Yield	Reaction Conditions	Operation in experiment
73%	With pyridine; thionyl chloride; at 0℃; for 1.58333h;	Step B: Thionyl chloride (11.0 ml, 150 mmol) was added over a period of 5 minutes to a solution of the product from Step A (2.3 g, 15 mmol) in pyridine (12 ml) at 0 C. and the resulting mixture was stirred at 0 C. for 90 minutes. Dichloromethane (100 ml) was added and the reaction was quenched carefully with 10% aqueous sodium bicarbonate (200 ml) to reach pH 5. Solid sodium bicarbonate (30 g) was then added followed by water (100 ml). The two layers were separated and the aqueous phase was extracted with dichloromethane (100 ml). The combined organic layers were washed with a 5% aqueous sodium bicarbonate (100 ml) and water (100 ml), and were dried over anhydrous magnesium sulfate. The crude was dissolved in dichloromethane and washed with 1N HCl twice and water to remove any residual pyridine. The organic layer was dried over anhydrous magnesium sulfate to give the desired benzofuran (1.5 g, 73%, 98.3% AUC HPLC): 1H NMR (500 MHz, DMSO-d6) delta 7.95 (d, J=1.9 Hz, 1H), 7.36 (d, J=7.6 Hz, 1H), 7.17-7.05 (m, 2H), 6.94 (t, J=2.5 Hz, 1H).
		Compound 1C. 7-Fluorobenzofuran [00114] To a solution of 7-fluoro-2,3-dihydrobenzofuran-3-ol (4.6 g, 29.8 mmol) in pyridine (93 mL) at 0 C was added SOCI2 (21.7 mL, 298 mmol) dropwise. Upon completion of addition, the mixture was stirred at 0 C for 1.5 h. At the conclusion of this period, the reaction mixture was carefully quenched with aqueous aHC03 (saturated, 100 mL) to reach a pH = 9. Once at the prescribed pH, the reaction mixture was extracted with CH2CI2 (4 X 15 mL). The combined organic layers were washed with aqueous NaHCCh (5%, 40 mL), water (40 mL), and then concentrated to yield the crude product. The crude product was dissolved in CH2CI2 (50 mL), washed with aqueous HC1 (1 N, 5 X 10 mL), and then water (40 mL). The organic layer was separated, dried (MgS04), filtered, and concentrated to afford Compound 1C as a brown oil (2.56 g). ¾ NMR (500 MHz, CDC13) delta ppm 7.67 (d, J=2.2 Hz, 1 H), 7.33 - 7.40 (m, 1 H), 7.17 (td, J=8.0, 4.4 Hz, 1 H), 7.04 (dd, J=10.7, 8.0 Hz, 1 H), 6.79 - 6.85 (m, 1 H).

References: [1]Patent: US2006/52378,2006,A1 .Location in patent: Page/Page column 95.
[2]Patent: WO2011/140161,2011,A1 .Location in patent: Page/Page column 53; 54.
[3]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2539 - 2545.

3
[ 24410-61-5 ]
7-fluorobenzofuran-2-ylsulfonylchloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
26%		A solution of <strong>[24410-61-5]7-fluorobenzofuran</strong> (0.90 g, 6.6 mmol) in diethyl ether (iO mE) was cooled to 00 C., i.3 mol/L tert-butyllithium (n-pentane solution, 6.i mE, 7.9 mmol) was added dropwise over 20 mi Sulthr dioxide was blown into the reaction mixture for 20 mi N-chlorosuccinimide (i.i g, 9.7 mmol) was added and the mixture was stirred for i hr. The reaction mixture was poured into ice water, extracted with ethyl acetate, and the organic layer was washed with saturated brine, and dried over sodium sulfate. The desiccant was filtered off, the solvent was evaporated and the obtained residue was purified by silica gel column chromatography (petroleum ether) to give the title compound (0.40 g, i.7 mmol, 26%).MS (ESI) mlz 235 (M+H7
		Step 1 Preparation of <strong>[24410-61-5]7-fluorobenzo[b]furan</strong>-2-ylsulfonyl chloride. Starting from <strong>[24410-61-5]7-fluorobenzo[b]furan</strong> (10.4 g), the objective compound (5.7 g) was obtained in a manner similar to Step 1 of Example 91.

References: [1]Patent: US2016/332999,2016,A1 .Location in patent: Paragraph 0258; 0259; 0260.
[2]Patent: US5004751,1991,A .

4
[ 24410-61-5 ]
2,3-dibromo-2,3-dihydro-7-fluorobenzo[b]furan [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With bromine; In carbon disulfide; tetrachloromethane;	Step 1 Preparation of 2,3-dibromo-2,3-dihydro-<strong>[24410-61-5]7-fluorobenzo[b]furan</strong>. To a solution of <strong>[24410-61-5]7-fluorobenzo[b]furan</strong> (16 g) in carbon tetrachloride (40 ml) was added dropwise a solution of bromine (22 g) in carbon disulfide (40 ml) at -30 C. and the solution was stirred for 1 hour. At room temperature, the formed precipitate was separated by filtration to give 34.4 g of the objective compound. IR (KBr, cm-1): 1634, 1601, 1489, 1459, 1279, 1179 NMR (CDCl3, ppm): 5.74 (1H, d, J=1.3 Hz),

References: [1]Patent: US5004751,1991,A .

5
[ 24410-61-5 ]
[ 1346529-55-2 ]

References: [1]Patent: WO2011/140161,2011,A1 .

6
[ 24410-61-5 ]
[ 1346529-56-3 ]

References: [1]Patent: WO2011/140161,2011,A1 .

7
[ 24410-61-5 ]
[ 1346529-57-4 ]

References: [1]Patent: WO2011/140161,2011,A1 .

8
[ 24410-61-5 ]
[ 1346529-58-5 ]

References: [1]Patent: WO2011/140161,2011,A1 .

9
[ 24410-61-5 ]
[ 1346529-59-6 ]

References: [1]Patent: WO2011/140161,2011,A1 .

10
[ 24410-61-5 ]
[ 1346529-60-9 ]

References: [1]Patent: WO2011/140161,2011,A1 .

11
[ 24410-61-5 ]
[ 1346529-02-9 ]

References: [1]Patent: WO2011/140161,2011,A1 .

12
[ 24410-61-5 ]
[ 1346529-03-0 ]

References: [1]Patent: WO2011/140161,2011,A1 .

13
[ 24410-61-5 ]
[ 1346529-61-0 ]

References: [1]Patent: WO2011/140161,2011,A1 .
[2]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2539 - 2545.

14
[ 24410-61-5 ]
[ 1346529-62-1 ]

References: [1]Patent: WO2011/140161,2011,A1 .
[2]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2539 - 2545.

15
[ 24410-61-5 ]
[ 1346529-63-2 ]

References: [1]Patent: WO2011/140161,2011,A1 .
[2]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2539 - 2545.

16
[ 24410-61-5 ]
[ 1346529-64-3 ]

References: [1]Patent: WO2011/140161,2011,A1 .

17
[ 24410-61-5 ]
[ 1346529-65-4 ]

References: [1]Patent: WO2011/140161,2011,A1 .
[2]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2539 - 2545.

18
[ 24410-61-5 ]
[ 79099-07-3 ]
[ 1346529-54-1 ]

Yield	Reaction Conditions	Operation in experiment
		Compound ID. tert-Butyl 4-(<strong>[24410-61-5]7-fluorobenzofuran</strong>-2-yl)-4-hydroxypiperidine-l- carboxylate[00115] To a solution of <strong>[24410-61-5]7-fluorobenzofuran</strong> (0.3 g, 1.807 mmol) in dry THF (4.8 mL) at -78 C under an argon atmosphere was slowly added BuLi (1.3 mL, 2.078 mmol). Upon completion of addition, the mixture was stirred at -78 C for 20 min. After this time, a solution of tert-butyl 4-oxopiperidine-l-carboxylate (0.36 g, 1.807 mmol) in THF (2.4 mL) was slowly added. The reaction mixture was warmed to -40 C, where it stirred for 2 hrs. At the conclusion of this period, the reaction mixture was quenched with aqueous NH4C1 (saturated, 5 mL) and then extracted with EtOAc (3 X 5 mL). The combined organic layers were washed with H2O (2 X 4 mL), brine (5 mL), dried (Na2S04), filtered, and concentrated to yield a residue. The residue was purified by column chromatography (silica gel, hexanes/EtOAc gradient 0 to 60% EtOAc) to afford Compound ID as a white solid (530 mg, 94.7% purity, 83% yield). 'H NMR (400 MHz, CDC13) delta ppm 7.30 (dd, J=7.8, 1.0 Hz, 1 H), 7.14 (td, J=7.9, 4.4 Hz, 1 H), 6.96 - 7.07 (m, 1 H), 6.64 (d, J=2.8 Hz, 1 H), 3.86 (br. s., 2 H), 3.39 (t, J=l 1.1 Hz, 2 H), 2.44 (t, J=6.2 Hz, 1 H), 2.08 - 2.21 (m, 2 H), 1.90 - 2.02 (m, 2 H), 1.44 - 1.50 (m, 9 H). LC/MS (m/z) = 336 (M+H)+.

References: [1]Patent: WO2011/140161,2011,A1 .Location in patent: Page/Page column 54; 55.
[2]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2539 - 2545.

19
[ 394-50-3 ]
[ 24410-61-5 ]

References: [1]Patent: WO2011/140161,2011,A1 .
[2]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2539 - 2545.

20
[ 1346529-53-0 ]
[ 24410-61-5 ]

References: [1]Patent: WO2011/140161,2011,A1 .
[2]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2539 - 2545.

21
[ 24410-61-5 ]
[ 1602574-52-6 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2539 - 2545.

22
[ 24410-61-5 ]
[ 1346529-66-5 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2539 - 2545.

23
[ 24410-61-5 ]
[ 1346529-67-6 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2539 - 2545.

24
[ 24410-61-5 ]
[ 1346529-68-7 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2539 - 2545.

25
[ 24410-61-5 ]
C₂₈H₃₇FN₄O₃S [ No CAS ]
C₂₈H₃₇FN₄O₃S [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2539 - 2545.

26
[ 24410-61-5 ]
[ 1346529-39-2 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2539 - 2545.

27
[ 24410-61-5 ]
[ 1346529-05-2 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2539 - 2545.

28
[ 24410-61-5 ]
[ 106-43-4 ]
[ 152862-74-3 ]

References: [1]Journal of Organic Chemistry,2015,vol. 80,p. 8916 - 8921.

29
[ 24410-61-5 ]
[ 108-90-7 ]
7-Fluoro-2-phenyl-benzofuran [ No CAS ]

References: [1]Journal of Organic Chemistry,2015,vol. 80,p. 8916 - 8921.

Historical Records

Technical Information

• Alkyl Halide Occurrence

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P378
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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
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P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 24410-61-5

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CAS No.: 24410-61-5

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[ 24410-61-5 ] Synthesis Path-Downstream 1~29

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