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Chemical Structure| 24277-38-1 Chemical Structure| 24277-38-1
Chemical Structure| 24277-38-1

*Storage: Sealed in dry,Room Temperature.

(S)-1-tert-Butyl 5-methyl 2-((tert-butoxycarbonyl)amino)pentanedioate

CAS No.: 24277-38-1

4.5 *For Research Use Only !

Cat. No.: A415563 Purity: 98%

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Product Details of [ 24277-38-1 ]

CAS No. :24277-38-1
Formula : C15H27NO6
M.W : 317.38
SMILES Code : O=C(OC(C)(C)C)[C@@H](NC(OC(C)(C)C)=O)CCC(OC)=O
MDL No. :MFCD27578332
InChI Key :IURKEBKDWQGPJJ-JTQLQIEISA-N
Pubchem ID :11120686

Safety of [ 24277-38-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis [ 24277-38-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 24277-38-1 ]

[ 24277-38-1 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 101990-45-8 ]
  • [ 24277-38-1 ]
  • 1-tert-butyl 5-methyl (2S,4S)-4-[(6-bromopyridin-3-yl)methyl]-2-[(tert-butoxy)carbonyl]amino}pentanedioate [ No CAS ]
YieldReaction ConditionsOperation in experiment
37.2% Compound (S)-2-((tert-Butoxycarbonyl)amino)-5-methoxy-5-oxopentanoic acid (1.5 g, 4.7 mmol)Dissolved in 25mL THF, then placed at -70 C, then slowly LiMHDS (lithium bis (trimethylsilyl) amide)(7 mL, 1 mol/L solution) was added to the above solution and added dropwise over 1 h. After the addition is completed, continue to react at this temperature.2h. Then 4-bromo-3-azabenzyl bromide (2.34 g, 9.4 mmol) 15 mL THF was added to the above reaction solution, and the reaction was continued at this temperature.4h. After quenching with 15 mL of HCl (1M), ethyl acetate (EtOAc (EtOAc) Dry over anhydrous sodium sulfate, remove the solvent,Column chromatography gave the product (0.85 g, 37.2%).
 

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