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Chemical Structure| 2426-84-8 Chemical Structure| 2426-84-8

Structure of 2426-84-8

Chemical Structure| 2426-84-8

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Product Details of [ 2426-84-8 ]

CAS No. :2426-84-8
Formula : C15H13NO5
M.W : 287.27
SMILES Code : O=CC1=CC(OC)=C(OCC2=CC=CC=C2)C=C1[N+]([O-])=O
MDL No. :MFCD02629357
InChI Key :WKDLWHKMVQVRNO-UHFFFAOYSA-N
Pubchem ID :561363

Safety of [ 2426-84-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Application In Synthesis of [ 2426-84-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 2426-84-8 ]

[ 2426-84-8 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 75-52-5 ]
  • [ 2426-84-8 ]
  • [ 2426-59-7 ]
YieldReaction ConditionsOperation in experiment
39.3%
Stage #1: at 100℃; for 5 h;
Stage #2: With silica gel; acetic acid In toluene at 110℃; for 1 h;
To a mixture of compound 3 (8.60 g, 30 mmol) in acetic acid (80 mL) was added CH3NO2 (10 mL) and NH4Ac (3.66 g, 60 mmol, 2 eq.). The reaction mixture was stirred at 100° C. for 5 h. The reaction mixture was concentrated, and the residue was taken up in a mixture of toluene (80 mL) and acetic acid (10 mL). To the reaction mixture was added iron powder (3.3 g, 60 mmol, 2 eq.) and silica gel (10 g). The reaction mixture was refluxed for 1 h, cooled to rt and filtered. The filtrate was concentrated, and the residue was partitioned between water and EtOAc. The organic layer was separated, dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel chromatography (petroleum ether/EtOAc=3/1) to give the desired product (3.0 g, 11.8 mmol, 39.3percent) as a yellow solid
References: [1] Patent: US2016/9706, 2016, A1, . Location in patent: Paragraph 0271.
 

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