4-Nitrophenylboronic acid | Organoboron

Abstract: Covalent organic framework (COF)-supported palladium catalysts have garnered enormous attention for cross-coupling reactions. However, the limited linkage types in COF hosts and their suboptimal catalytic performance have hindered their widespread implementation. Herein, we present the first study immobilizing palladium acetate onto a dioxin-linked COF (Pd/COF-318) through a facile solution impregnation approach. By virtue of its permanent porosity, accessible Pd sites arranged in periodic skeletons, and framework robustness, the resultant Pd/COF-318 exhibits exceptionally high activity and broad substrate scope for the Suzuki-Miyaura coupling reaction between aryl bromides and arylboronic acids at room temperature within an hour, rendering it among the most effective Pd/COF catalysts for Suzuki-Miyaura coupling reactions to date. Moreover, Pd/COF-318 demonstrates excellent recyclability, retaining high activity over five cycles without significant deactivation. The leaching test confirms the heterogeneity of the catalyst. This work uncovers the vast potential of dioxin-linked COFs as catalyst supports for highly active, selective, and durable organometallic catalysis.

Keywords: covalent organic framework (COF) ; dioxin-linked COF ; Pd(II) immobilization ; Suzuki-Miyaura coupling

Purchased from AmBeed: 24067-17-2 ; 98-80-6 ; 3375-31-3 ; 71597-85-8 ; 4877-80-9 ; 99768-12-4

Product Details of 4-Nitrophenylboronic acid

CAS No. :	24067-17-2
Formula :	C₆H₆BNO₄
M.W :	166.93
SMILES Code :	OB(C1=CC=C([N+]([O-])=O)C=C1)O
Synonyms :	4-Nitrobenzeneboronic Acid; p-Nitrophenylboronic Acid; p-nitro-Benzeneboronic Acid
MDL No. :	MFCD00161360
InChI Key :	NSFJAFZHYOAMHL-UHFFFAOYSA-N
Pubchem ID :	2773552

Safety of 4-Nitrophenylboronic acid

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of 4-Nitrophenylboronic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 24067-17-2 ]

[ 24067-17-2 ] Synthesis Path-Downstream 1~14

1
[ 62224-16-2 ]
[ 24067-17-2 ]
[ 666721-41-1 ]

Yield	Reaction Conditions	Operation in experiment
78%	With potassium phosphate;tetrakis(triphenylphosphine) palladium(0); In 1,2-dimethoxyethane; at 80℃; for 3h;	(4-Nitrophenyl) boronic acid (1.2 equivalents), tetrakis (TRIPHENYLPHOSPHINE) palladium (0) (0.03 equivalent) and 2. 0M potassium phosphate solution (2.1 equivalents) are added to a solution under nitrogen of methyl 4-BROMOTHIOPHENE-2-CARBOXYLATE in 3.0 ml of degassed DME. The reaction medium is then stirred for 3 hours at 80oC, diluted with ethyl acetate (20 ml), washed with water (2X15 ml), dried over sodium sulphate, filtered and concentrated under reduced pressure. Chromatography of the residue on silica gel (98/2 dichloromethane/methanol) allows 1.94 g of the expected product to be isolated. Yield: 78% H NMR (CDC13) 5 (PPM) : 3.92 (s, 3H), 7.75 (d, 2H), 7.82 (s, 1H), 8.12 (s, 1H), 8.30 (d, 2H)
78%	With potassium phosphate;tetrakis(triphenylphosphine) palladium(0); In 1,2-dimethoxyethane; water; at 80℃; for 3h;	To a solution of <strong>[62224-16-2]methyl 4-bromothiophen-2-carboxylate</strong> and 1.2 equivalents of (4-nitrophenyl) boronic acid in DME were added 2. [1] equivalents of a 2.0 M solution of potassium phosphate and 0.03 equivalent of tetrakis (triphenylphosphie) palladium (0). After stirring at [80XB0;C] for 3 hours the mixture was concentrated under reduced pressure. The residue was diluted with ethyl acetate, filtered over Celite, washed with water, dried over sodium sulfate, and then concentrated under vacuum. The residue was purified on a silica gel column using 9: [1] cyclohexane: ethyl acetate to yield 1.94 g (78%) of the desired compound.

References: [1]Patent: WO2005/3114,2005,A1 .Location in patent: Page 20.
[2]Patent: WO2004/14381,2004,A2 .Location in patent: Page/Page column 42-43.

2
[ 7617-93-8 ]
[ 24067-17-2 ]
[ 835904-78-4 ]

Yield	Reaction Conditions	Operation in experiment
99%	With potassium carbonate;trans-benzyl(chloro)-bis(triphenylphosphine)palladium(II); In 1-methyl-pyrrolidin-2-one; at 110℃; for 48.0h;	2,5-BIS (TRIFLUOROMETHYL) BROMOBENZENE (0.59 G, 2.00 MMOL, 1.00 EQUIV. ), 4- nitrophenylbronic acid (0.334 g, 2. 00 mmol, 1.00 equiv. ), trans- benzyl (chloro) bis (TRIPHENYLPHOSPHINE) PALLADIUM (LL) (0.076 g, 0.10 mmol, 0.05 EQUIV.), K2CO3 1.38 g, 10.00 MMOL, 5.00 equiv. ) and 10 mL dry NMP were charged to a 25 mL round bottom flask. The mixture was thoroughly de- oxygenated by subjecting to vacuum/nitrogen cycle three times, and heated at 110 C for 2 days under nitrogen protection. Usual workup yielded crude product 4'-nitro-2, 5-bis-trifluoromethyl-biphenyl as brown viscous oil (0. 66 g, 1.97 mmol, 99%). H NMR (300 MHz, CDCl3), 6 (ppm): 8.32 (d, J = 8.7 Hz, 2H); 7. 82-8. 00 (m, 2H); 7.52-7. 61 (m, 3H).The crude product made in the last step was dissolved in 10 mL methylene chloride and 10 mL ethanol. Tin (II) CHLORIDE (2.28 g, 12.00 mmol, 6.00 equiv) was added, followed by addition of 1 mL water. After stirring at room temperature for 2 days, the mixture was neutralized with 2 N NAOH solution, and subjected to usual workup to yield crude product 4'-amino-2, 5-bis-trifluoromethyl- biphenyl (0.52 g, 1.70 mmol, 85% crude yield) as brown viscous oil.4'-Amino-2, 5-bis-trifluoromethyl-biphenyl (0.16 g, 0.50 mmol, 1.00 equiv) was dissolved in 10 mL methylene chloride. To the solution was added 2,3- DIFLUOROBENZOYL chloride (0. 088 g, 0.50 mmol, 1.00 equiv), and triethylamine (0.061 g, 0.60 mmol, 1.20 equiv). The mixture was stirred at room temperature for one hour, and loaded to column for flash chromatography. The title compound was isolated as light yellow solid (0.12 g, 0.27 mmol, 54%). 1H NMR (300 MHz, CDCI3), 6 (PPM) : 8. 39 (D, J= 10.5 Hz, 1H) ; 7.75-7. 95 (m, 6H); 7.63 (s, 1H); 7.26-7. 443 (m, 3H); ESMS CALCD. FOR C21H12F8NO (M + H) + : 446.0 ; Found: 446.0

References: [1]Patent: WO2005/9954,2005,A2 .Location in patent: Page 117-119.

3
[ 1074-24-4 ]
[ 24067-17-2 ]
[ 152219-88-0 ]

References: [1]Journal of the American Chemical Society,2011,vol. 133,p. 13652 - 13660.

4
[ 1075-34-9 ]
[ 24067-17-2 ]
[ 1246375-58-5 ]

Yield	Reaction Conditions	Operation in experiment
	(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 120℃;Microwave irradiation;	Compound 296; N-hydroxy-7-(N-(4-(2-methyl-1H-indol-5-yl)phenyl)methylsulfonamido)heptanamide; As shown in reaction scheme 4,6-bromo-2-methyl-1H-indole and 4-nitrophenylboronic acid were subjected to the Suzuki reaction to obtain compound 2, which was then reduced with palladium/activated carbon to obtain compound 3. Then, compound 3 is allowed to react with ethyl 7-bromoheptanoate to obtain compound 4, which was then allowed to react with methanesulfonyl chloride to obtain a compound of formula V-1, after which the compound of formula V-1 (16 mg, 0.035 mmol) was stirred with hydroxylamine and potassium hydroxide for 30 minutes. Then, a 50percent water solution of hydroxylamine was added to the stirred solution until the undissolved solids were dissolved so that the solution became clear. Then, the reaction solution was stirred at mom temperature for 10 hours, and after the completion of the reaction has been confirmed, the reaction product was concentrated under reduced pressure to remove the solvent. The remaining material was extracted using ethyl acetate, washed with brine, dried with anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was crystallized, thus obtaining compound 296 (12 mg, 77.3percent).1H NMR (400 MHz, CD3OD) delta 7.67 (d, J=1.9 Hz, 2H), 7.65 (s, 1H), 7.41 (d, J=6.6 Hz, 2H), 7.30 (d, J=3.5 Hz, 2H), 6.17 (s, 1H), 3.71 (t, J=6.7 Hz, 2H), 2.93 (s, 3H), 2.42 (s, 3H), 2.05 (t, J=7.3 Hz, 2H), 1.57 (m, 4H), 1.31 (m, 4H). MS (ESI) m/z 443 (M++H).
	(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 120℃;Microwave;	As shown in reaction scheme 4, 6-bromo-2-methyl-1H-indole and 4-nitrophenylboronic acid were subjected to the Suzuki reaction to obtain compound 2, which was then reduced with palladium/activated carbon to obtain compound 3. Then, compound 3 is allowed to react with ethyl 7-bromoheptanoate to obtain compound 4, which was then allowed to react with methanesulfonyl chloride to obtain a compound of formula V-1, after which the compound of formula V-1 (16 mg 0.035 mmol) was stirred with hydroxylamine and potassium hydroxide for 30 minutes. Then, a 50percent water solution of hydroxylamine was added to the stirred solution until the undissolved solids were dissolved so that the solution became clear. Then, the reaction solution was stirred at room temperature for 10 hours, and after the completion of the reaction has been confirmed, the reaction product was concentrated under reduced pressure to remove the solvent. The remaining material was extracted using ethyl acetate, washed with brine, dried with anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was crystallized, thus obtaining compound 296 (12 mg, 77.3percent). 1H NMR (400 MHz, CD3OD) delta 7.67 (d, J = 1.9 Hz, 2H), 7.65 (s, 1H), 7.41 (d, J = 6.6 Hz, 2H), 7.30 (d, J = 3.5 Hz, 2H), 6.17 (s, 1H), 3.71 (t, J = 6.7 Hz, 2H), 2.93 (s, 3H), 2.42 (s, 3H), 2.05 (t, J = 7.3 Hz, 2H), 1.57 (m, 4H), 1.31 (m, 4H). MS (ESI) m/z 443 (M+ + H).

References: [1]Patent: US2012/28963,2012,A1 .Location in patent: Page/Page column 24.
[2]Patent: EP2412706,2012,A2 .Location in patent: Page/Page column 40-41.

5
[ 105404-89-5 ]
[ 24067-17-2 ]
[ 1426232-29-2 ]

Yield	Reaction Conditions	Operation in experiment
90%	With tetrakis(triphenylphosphine) palladium(0); caesium carbonate; In 1,4-dioxane; water;Inert atmosphere; Reflux;	General procedure: To a solution of 2,7-dibromonaphthalene (300 mg, 1.05 mmol) in1,4-dioxane (10 mL) were added 4-nitrophenylboronic acid (381 mg, 2.28 mmol), Pd(PPh3)4 (28 mg, 0.024 mmol), and aq. Cs2CO3 (2 M, 2 mL), and the reaction mixture was stirred overnight at reflux under Ar. Then, the reaction mixture was diluted with water (30 mL), and the product was extracted with chloroform (100 mL × 3). The organic layer was dried over MgSO4 and concentrated in vacuo. The residue was purified by column chromatography [hexane/chloroform (2:1)] to give 2,7-bis(4-nitrophenyl)naphthalene 3a (326 mg, 0.879 mmol, 84%) as a yellow solid

References: [1]Tetrahedron Letters,2013,vol. 54,p. 1839 - 1841.

6
[ 57876-69-4 ]
[ 24067-17-2 ]
3-methyl-2-(4-nitrophenyl)quinoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
88%	With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In 1,2-dimethoxyethane; water; at 120℃; for 1h;Microwave irradiation; Inert atmosphere;	<strong>[57876-69-4]2-chloro-3-methylquinoline</strong> (1 .00 g, 5.65 mmol), (4-nitrophenyl)boronic acid (1 .20 g, 7.22 mmol), and Pd(PPh3)2C12 catalyst (19.7 mg) was added to DME (16 mL)in a microwave vial. 2M aqueous potassium carbonate was added (4 mL) added, vial capped and then mix degassed with nitrogen before being irradiated in the microwave at 120C for 1 hour. The reaction mixture was partitioned between ethyl acetate and sat. aqueous sodium bicarbonate solution. Organic phase was washed with water, dried (Mg504) and concentrated to give a light tan solid, which was purified by flash chromatography on silica gel (40g), eluting with a gradient of 20-50% EtOAc in hexane to give a light-cream solid (1.32 g, 88%).

References: [1]Patent: WO2015/40425,2015,A1 .Location in patent: Page/Page column 180; 181.

7
[ 288-88-0 ]
[ 24067-17-2 ]
[ 6219-55-2 ]

Yield	Reaction Conditions	Operation in experiment
84%	With copper(I) 2-hydroxy-3-methylbenzoate; potassium carbonate; In methanol; at 65℃; for 3h;	General procedure: A dry flask was charged with the nitrogen containing heterocycles (1 mmol), aryl boronic acids (2.2 mmol), potassium carbonate (2 mmol) andCuMeSal (0.015 mmol)then anhydrous methanol (10 ml) was added. The reaction mixture was stirred at 65 oC, open to air, for 3 h (5 h in case of indole and benzimidazole), cooled to room temperature, filtered, and the precipitate was washed with methanol (2 ml), the filtrate was concentrated under vacuum, then stirred with ice water (30 ml) and extracted with ethyl acetate (3 × 50 ml), dried over sodium sulfate and the solvent was removed under reduced pressure. The residue was purified by chromatography or recrystallization as indicated with each compound.

References: [1]Synthetic Communications,2015,vol. 45,p. 245 - 252.

8
[ 1120-95-2 ]
[ 24067-17-2 ]
3-(4-nitrophenyl)pyridazine [ No CAS ]

References: [1]Organic Letters,2015,vol. 17,p. 5878 - 5881.

9
[ 13031-43-1 ]
[ 24067-17-2 ]
[ 107558-16-7 ]

Yield	Reaction Conditions	Operation in experiment
89%	With copper(l) iodide; sulfur; sodium t-butanolate; at 60 - 80℃; for 10h;	General procedure: A one-necked flask was charged with CuI (30 mg, 0.15 mmol), NaOt-Bu (376 mg, 4.0 mmol), S8 (47 mg, 1.5 mmol), phenolic ester (1 mmol), arylboronic acid (1.1 mmol), and PEG200 (2 mL). The mixture was magnetically stirred and heated at 60-80 C for the appropriate reaction time (Table 2). After completion of the reaction, the reaction mixture was cooled to r.t. H2O (4 mL) was added and the product was extracted with EtOAc (3 × 4 mL) and dried (anhyd Na2SO4). Evaporation of the solvent and purification by column chromatography on silicagel (n-hexane/EtOAc) gave the desired unsymmetrical diaryl sulfides in 74-95% yields.

References: [1]Synthesis,2017,vol. 49,p. 5025 - 5038.

10
[ 24067-17-2 ]
[ 67-68-5 ]
[ 16687-60-8 ]

References: [1]Journal of Organic Chemistry,2017,vol. 82,p. 887 - 892.

11
[ 858629-06-8 ]
[ 24067-17-2 ]
5-fluoro-3-(4-nitrophenyl)-1H-indazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
95.4%	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 80℃;	To a solution of <strong>[858629-06-8]5-fluoro-3-iodo-1H-indazole</strong> (2.0 g, 7.6 mmol) in dioxane (40 mL) and H20 (10 mL) was added 4-nitrophenylboronic acid (1.89 g, 11.4 mmol) and K2C03 (2.09 g, 15.2 mmol), Pd(dppf)C12 (555.56 mg, 0.76 mmol), the mixture was stirred at 80 C overnight. The reaction was monitored by TLC. After completion, the mixture was filtered, the filtrate was concentrated in vacuum to give a residue, which was purified by a silica gel column (PE/EA = 3/1) to afford 5-fluoro-3-(4-nitro-phenyl)-1H-indazole (1.87 g, yield: 95.4%) as a yellow solid. ‘HNIVIR (400 IVIHz, DMSO-d6): ö = 14.06 (s, 1H), 8.41-8.28 (m, 4H), 7.99 (dd,J 7.2, 2.0 Hz, 1H), 7.73 (dd, J 4.4, 4.8 Hz, 1H), 7.41-7.33 (m, 1H)

References: [1]Patent: WO2018/132372,2018,A1 .Location in patent: Paragraph 01230.

12
[ 16870-28-3 ]
[ 24067-17-2 ]
2-hydroxy-4-(4-nitrophenyl)benzoic acid potassium salt [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 7144 - 7167.

13
[ 3034-53-5 ]
[ 24067-17-2 ]
[ 3704-41-4 ]

Yield	Reaction Conditions	Operation in experiment
56.00%	With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate; In 1,4-dioxane; water; toluene; at 80℃; for 12h;Inert atmosphere;	A mixture of 4-nitrophenyl)boronic acid (23.00 g, 137.78 mmol, 1.00 eq.), 2-bromothiazole (25.54 g, 155.69 mmol, 14.03 mL, 1.13 eq.), Na2C03 (36.51 g, 344.45 mmol, 2.50 eq.) and Pd(dppf)Cl2.CH2Cl2 (6.75 g, 8.27 mmol, 0.06 eq.) in Tol. (250.00 mL)/H20 (100.00 mL)/dioxane (250.00 mL) was degassed and purged with N2 for 3 times. The mixture was stirred at 80C for 12 hrs under N2 atmosphere and LCMS showed the reaction was complete. The mixture was concentrated and the residue was purified by column chromatography (Petroleum ethenEthyl acetate=50: l to 5: 1) to give 2-(4-nitrophenyl)thiazole (14.00 g, 67.89 mmol, 56.00% yield) as a yellow solid. 1H NMR (400MHz, CHLOROFORM-d) delta = 8.35 - 8.29 (m, 2H), 8.21 - 8.12 (m, 2H), 7.99 (d, J = 3.2 Hz, 1H), 7.50 (d, J = 3.2 Hz, 1H).

References: [1]Patent: WO2019/14315,2019,A1 .Location in patent: Page/Page column 26-27.

14
[ 16870-28-3 ]
[ 24067-17-2 ]
4-(4-nitrophenyl)-2-hydroxybenzoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
69.5%	With palladium diacetate; potassium carbonate; triphenylphosphine; In water; N,N-dimethyl-formamide; at 100℃; for 3h;Inert atmosphere; Microwave irradiation; Sealed tube;	<strong>[16870-28-3]2-hydroxy-4-iodobenzoic acid</strong> (50 mg, 0.189 mmol), 4-nitrobenzeneboronic acid (38 mg, 0.227 mmol), PPh3 (7.4 mg, 0.028 mmol), K2CO3 (91.4 mg, 0.662 mmol), Pd(AcO)2 (2.12 mg, 0.0095 mmol), 1:1 DMF: H2O (2 ml) were used. In this case, prior to chromatographic purification, the residue from evaporating the filtrate was resuspended in acetonitrile. The precipitate was separated from the liquid phase and the latter was discarded. The solid was then purified by flash chromatography (elution with AcOEt: CH3CN:H2O:CH3OH 70:10:5:5 mixture). Compound 101 was obtained as a yellowish solid. Yield after purification: 69.5 % (34 mg). 1H NMR (500 MHz, methanol-d4) delta 8.31 (d, J = 8.9 Hz, 2H), 7.96 (d, J = 7.94 Hz, 1H), 7.87 (d, J = 8.9 Hz, 2H), 7.17-7.13 (m, 2H). 13C NMR (126 MHz, methanol-d4) delta 175.2 (CO), 163.1 (C), 148.7 (C), 148.2 (C), 144.5 (C), 132.4 (CH), 129.1 (2CH), 124.9 (2CH), 119.5 (C), 118.1 (CH), 116.1 (CH). HRMS (TOF, ES-): Calculated for C13HsNO5: (M-H)-: m/z 258.0402. 258.0411 found (deviation 3.5 ppm). m.p. (C) > 300

References: [1]Patent: EP3593803,2020,A2 .Location in patent: Paragraph 0074; 0083.

Historical Records

Technical Information

• Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Friedel-Crafts Reaction • Hydrogenolysis of Benzyl Ether • Preparation of Alkylbenzene • Reactions of Benzene and Substituted Benzenes • Vilsmeier-Haack Reaction

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P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

Product Citations

Alternative Products

Product Details of 4-Nitrophenylboronic acid

Safety of 4-Nitrophenylboronic acid

Application In Synthesis of 4-Nitrophenylboronic acid

[ 24067-17-2 ] Synthesis Path-Downstream 1~14

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