Structure of 24033-49-6
*Storage:
*Shipping:
CAS No. : | 24033-49-6 |
Formula : | C10H13NO |
M.W : | 163.22 |
SMILES Code : | CC1=CC=C(OCC(C)N2)C2=C1 |
MDL No. : | MFCD19374520 |
InChI Key : | SEFPQGGFTLHJHO-UHFFFAOYSA-N |
Pubchem ID : | 23360989 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H315-H319 |
Precautionary Statements: | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | With platinum on activated charcoal; hydrogen; In 2-methyl-propan-1-ol; toluene; at 60℃; under 11251.1 Torr; for 10.0h; | General procedure: Pt/C (2 g) was added to solution of compounds 1 (50 mmol) in mixture of toluene (200 mL) andisopropanol (100 mL). The reaction mixture was stirred in H2 at 60 , 1.5 Mpa for 10 h. Then themixture was filtered, and the filtrate was dried over magnesium sulfate anhydrous, and the toluene wasremoved under vacuum. The crude product was separated on silica gel by column chromatography [V(EtOAc): V (light petroleum) = 1:4] until the compounds 2 were collected. |
87% | With platinum on activated charcoal; hydrogen; In isopropyl alcohol; toluene; at 60℃; under 11251.1 Torr; for 10.0h; | General procedure: Pt/C (2g) was added to solution of compounds 2a-f (50 mmol) in mixture of toluene (200 ml) and isopropanol (10ml). the reaction mixture was stirredin a hydrogen atmosphere at 60, 1.5 Mpa for 10 hr. Then the mixture was filtered, and the filtrate was driedover magnesium sulfate anhydrous and the toluene was removed under vacuum. The crude product was separated on silica gel by column chromatography[V(EtOAc): V (light petroleum) = 1:4] until the benzoxazines 3a-f were collected. |
87% | With platinum on activated charcoal; hydrogen; In isopropyl alcohol; toluene; at 55 - 60℃; under 11251.1 Torr; for 10.0h; | General procedure: Pt/C (2 g) was added to a solution of compound 1 (50 nmol) in the mixture of toluene (200 mL) and isopropanol (100 mL). The reaction mixture was stirred in H2 at 60, 1.5 Mpa for 10 h. Then the mixture was filtered, and the filtrate was dried over magnesium sulfate anhydrous, and the toluene was removed under vacuum. The crude product was separated on silicagel by column chromatography [V (EtOAc): V (lightpetroleum) = 1:4] until the benzoxazine 2 were collected. The physical and spectra data of the compounds 2 were as follows: |
54.9% | With platinum on carbon; hydrogen; In isopropyl alcohol; toluene; at 55℃; under 11251.1 Torr; for 20.0h; | General procedure: Nitrophenoxy-2-propanone 2 (0.05 mol), toluene (250 mL), and isopropanol (100 mL) were added to the high pressure reactor with 5% Pt/C (2.0 g) as catalyst. After the connection device, hydrogen was filled to system and maintained pressure at 1.5 MPa during the reaction, the reaction mixture was continuously stirred at 55C and 200 r/min for 20 h. When the progress was finished, the crude product was collected by filtration and concentration. Then, it was purified on silica gel by column chromatography using petroleum ether/EtOAc as eluent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With potassium carbonate; In benzene; at 20℃; for 1.0h; | General procedure: Phenoxyacetyl chloride (21 mmol) was dropwise added to the mixture of K2CO3 (15.2 mmol, 1.6 g),3-methyl-3,4-dihydro-2H-1,4-benzoxazine (14 mmol) and benzene (34 mL) at room temperature for 1 h.Then the mixture was filtered, and the filtrate was washed and dried over magnesium sulfate anhydrous.The benzene was removed under vacuum. The crude products were recrystallized with EtOAc and lightpetroleum. |
77.1% | With potassium carbonate; In toluene; at 20 - 25℃; for 1.5h; | General procedure: The phenoxyacetyl chloride (21 mmol) was added dropwise to the 3-methyl-3,4-dihydro-2H-1,4-benzoxazine 3 (14 mmol) dissolved in toluene (30 mL) with anhydrous K2CO3 as the attaching acid agent at 20~25C, and the mixture was stirred for 1.5 h. On completion of the reaction (TLC monitored), the mixture was filtered and washed with water. The organic layer was dried over anhydrous MgSO4 and filtered. After removal of the solvent, the residue was purified by column chromatography on silica gel using petroleum ether/EtOAc as eluent to obtain the target compounds 4a and 4b. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
56% | With sodium carbonate; In benzene; at 20℃; for 2.0h; | General procedure: Dichloroacetyl chloride (17.6 mmol) was addedslowly in the mixture containing compounds 3a-f (14mmol), Na2CO3 (15.2 mmol), benzene (25 ml). The system was stirred at room temp for 2 hr. TLC monitored the reaction. Then the mixture was rinsed,and the organic phase was dried over anhydrousmagnesium sulfate. Benzene was removed under vacuum. The crude products 4a-f were obtained and recrystallized from ethanol and light petroleum. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With potassium carbonate; In benzene; at 20℃; for 1.5h; | General procedure: Acetoxyacetyl chloride (17.6 mmol) was slowly added to a mixture of K2CO3(15.2 mmol), compound 2 (14 mmol) and benzene (34 mL) at room temperature. TLC monitored the reaction. Then the mixture was cooled, washed with water, and filtered.The filtrate was washed and dried over magnesium sulfate anhydrous. Benzene was removed under vacuum. The crude products were recrystallized with EtOAc and light petroleum. The physical and spectra data of the compounds 3a-f were as follows |
Tags: 24033-49-6 synthesis path| 24033-49-6 SDS| 24033-49-6 COA| 24033-49-6 purity| 24033-49-6 application| 24033-49-6 NMR| 24033-49-6 COA| 24033-49-6 structure
A1084198 [944356-53-0]
6,8-Dimethyl-3,4-dihydro-2H-benzo[b][1,4]oxazine
Similarity: 0.85
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :
Total Compounds: mg
The concentration of the dissolution solution you need to prepare is mg/mL