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Chemical Structure| 2396-80-7 Chemical Structure| 2396-80-7

Structure of 2396-80-7

Chemical Structure| 2396-80-7

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Product Citations

Product Citations

Andrew R. Mahoney ; Kelly M. Storek ; William M. Wuest ;

Abstract: The search for antibiotics that function through novel mechanisms of action is ongoing, and recent progress in our lab identified the tricarboxylic acid cycle as a viable option. Promysalin is a secondary metabolite capable of species-specific inhibition of Pseudomonas aeruginosa, a common opportunistic pathogen. Promysalin disrupts primary metabolism in this bacterium by competitively inhibiting succinate dehydrogenase at the ubiquinone binding site. However, the activity of promysalin in cellulo is marred potentially by its chemical instability and/or propensity for efflux. To assess the success of these novel analogues, a novel strain of P. aeruginosa harboring gene deletions of eight efflux pumps and porins was developed and implemented. Herein, we disclose the synthesis and biological investigation of six promysalin analogues to overcome these liabilities and demonstrate that efflux likely plays a significant role in tolerating the effect of the inhibitor.

Purchased from AmBeed: ; 24850-33-7 ; 58479-61-1 ; ; 67843-74-7 ; ; 37342-97-5 ; 18162-48-6 ; 34164-50-6 ; ; 1310-73-2 ; 814-68-6 ; 111-71-7 ; 693-25-4

Alternative Products

Product Details of [ 2396-80-7 ]

CAS No. :2396-80-7
Formula : C7H12O2
M.W : 128.17
SMILES Code : C=CCCCC(OC)=O
MDL No. :MFCD00671538
InChI Key :ASKDFGVMJZMYEM-UHFFFAOYSA-N
Pubchem ID :520082

Safety of [ 2396-80-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H302
Precautionary Statements:P305+P351+P338
Class:3
UN#:3272
Packing Group:

Application In Synthesis of [ 2396-80-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2396-80-7 ]

[ 2396-80-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2396-80-7 ]
  • [ 14437-03-7 ]
  • (Z)-methyl 6-(N-(methoxycarbonyl)-4-methylphenylsulfonamido)hex-4-enoate [ No CAS ]
  • [ 1176891-03-4 ]
 

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[ 2396-80-7 ]

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