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Structure of 2370-88-9
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 2370-88-9 |
Formula : | C4H16O4Si4 |
M.W : | 240.51 |
SMILES Code : | C[SiH]1O[SiH](C)O[SiH](C)O[SiH](C)O1 |
MDL No. : | MFCD00039567 |
InChI Key : | WZJUBBHODHNQPW-UHFFFAOYSA-N |
Pubchem ID : | 6327421 |
GHS Pictogram: |
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Signal Word: | Danger |
Hazard Statements: | H225 |
Precautionary Statements: | P210-P403+P235 |
Class: | 3 |
UN#: | 1993 |
Packing Group: | Ⅲ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With tridodecylamine;2C8H18S*2Cl(1-)*Pt(2+); In ethanol; toluene; for 2h;Heating / reflux; | This example describes the attempted preparation of 1,3,5,7-tetrakis(1,2-epoxy-4-cyclohexylethyl)-1,3,5,7-tetramethylcyclotetra-siloxane, DE4, (represented by formula (III)) using PtCl2(SEt2)2 as the hydrosilation catalyst. A 250 ml 3-necked round-bottomed flask, equipped with a condenser, addition funnel, and thermometer was charged with VCHO (30 g, 242 mmol) followed by 3 microliters of PtCl2(SEt2)2 catalyst solution (375 ppb Pt based on final product weight), 4 microliters of tridodecylamine, and 50 ml toluene.. The reaction solution was heated to reflux with stirring.. To this mixture was added 6.5 g (27.1 mmol) DH4 (1,3,5,7-tetramethylcyclotetramethylsiloxane) was added drop wise via a syringe.. After addition of the DH4 reactant, the resulting mixture was refluxed for 90 min.. The IR spectrum of an aliquot of the reaction mixture indicated the presence of some unreacted DH4 silane.. An additional 3 microliters of the above platinum catalyst solution (equivalent to 375 ppb more of Pt based on final product weight) was added, and the reaction mixture was refluxed for an additional 30 min.. The reaction mixture was cooled to room temperature and stripped under vacuum.. The residual material remaining in the flask was a thick, yellow-green oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
2C8H18S*3Cl(1-)*Rh(3+); In ethanol; hexane; at 95 - 128.5℃; for 4.5h;Heating / reflux; | This example describes the attempted preparation of 1,3,5,7-tetrakis(1,2-epoxy-4-cyclohexylethyl)-1,3,5,7-tetramethylcyclotetra-siloxane, DE4, (represented by formula (III)) using RhCl3(SBu2)3 as the hydrosilation catalyst. This reaction was carried out under dry nitrogen, using hot glassware set-up.. A 250 ml 3-necked round-bottomed flask, equipped with a condenser, addition funnel, and thermometer was charged with VCHO (30 g, 242 mmol) under nitrogen flow, followed by 3 microliters of RhCl3(SBu2)3 catalyst solution (containing 1 ppm Rh based on final product weight) and approximately 50 ml hexane.. The addition funnel was charged with DH4 (12.9 g, 53.7 mmol) under nitrogen, followed by hexane (10 ml).. The reaction solution was heated to reflux with stirring.. One third of the DH4 solution was added drop wise, with no obvious result (e.g., onset of a reflux and/or a rise in reaction mixture temperature), and the reaction refluxed 30 min.. The mixture was tested by infrared, showing a large Si-H peak.. An additional 3 microliters of the rhodium catalyst solution (equivalent to 1 ppm more of Rh based on final product weight) was added, but there was still no reaction.. One half of the remaining DH4 solution and an additional 3 microliters of catalyst solution (equivalent to 1 ppm more of Rh based on final product weight) were added, followed by continued reflux.. A check of the reaction by IR showed a very large Si-H peak indicating a large amount of unreacted DH4.. The hexane was stripped off at atmospheric pressure to give a concentrated reaction mixture, which was heated to reflux, resulting in a solution temperature of 128.5C. The remaining DH4/hexane solution was then added, causing the reaction temperature to drop to 105C. After refluxing for about 3 hours, IR spectroscopic analysis showed that some unreacted DH4 was still present.. To this mixture was added 6 microliters more of the catalyst solution (equivalent to 2 ppm more of Rh based on final product weight), followed by refluxing to 95C. This led to an increase in viscosity of the reaction mixture, however unreacted DH4 was still present, as shown by IR spectral analysis.. Cooling the reaction mixture to room temperature afforded a liquid whose viscosity was visually much higher than expected. | |
platinum(II)Cl2(bis(triphenylphsphine)); In dichloromethane; toluene; at 123 - 135℃; for 3h;Heating / reflux; | This example describes the preparation of 1,3,5,7-tetrakis(1,2-epoxy-4-cyclohexylethyl)-1,3,5,7-tetramethylcyclotetra-siloxane, DE4, (represented by formula (III)) using parts per billion levels of PtCl2(PPh3)2 as the hydrosilation catalyst. A 1-liter, 3-necked round-bottomed flask equipped with two condensers and a thermometer was charged with VCHO (122 g. 981 mmol).. 49 g (204 mmol) DH4 (1,3,5,7-tetramethylcyclotetrasiloxane), 4 microliters of PtCl2(PPh3)2 catalyst solution (140 ppb Pt based on final product weight) and 83 g toluene.. The reaction solution was heated to reflux with stirring, resulting in a solution temperature of 123C. At this point the reaction mixture began to reflux vigorously, with the solution temperature reaching 135C initially, and thereafter settling down at 130C. The mixture was then refluxed for about 3 hours.. At this point, the infrared spectrum of an aliquot of the reaction mixture showed no Si-H absorption indicating complete consumption of DH4The solution was cooled to room temperature, and the condensers and thermometer were replaced with stopcocks and a short-path distillation head.. The solution was heated with a water bath at 85C and stripped of volatile components until the vapor temperature was above 70C. No gel formation was observed during and after the stripping process.. Proton NMR spectrum of the residual material in the reaction flask showed it to be the desired product and free of residual solvent and VCHO. In this manner, 148 g of (III) was obtained as a colorless material. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
A 500-mL round-bottomed flask equipped with a Teflon-coated stir bar and a reflux condenser was charged with 8.75 g (146 mmol Si-H) of tetramethylcyclosiloxane. To the flask were also added 4-vinyl-1-cyclohexene-1,2-epoxide (108 mmol, 13.4 g), toluene (100 g) and two crystals of chloroplatinic acid. The solution was stirred and refluxed for 3 hours to complete the hydrosilation. After cooling to room temperature, BHT (200 ppm) was added to the flask along with allylmethacrylate (38 mmol, 4.8 g). A gas dispersion tube was inserted into the flask and a small amount of air was bubbled into the stirred solution, while heating to 80 C. for 2 hours to complete the hydrosilation. The cooled solution was filtered through 10 g of silica gel, and after removal of the solvent 27 g of a viscous clear liquid was collected. | ||
Example 13; A 500-mL round-bottomed flask equipped with a Teflon-coated stir bar and a reflux condenser was charged with 8.75 g (146 mmol Si-H) of tetramethylcyclosiloxane. To the flask were also added vinyl cyclohexene-oxide (108 mmol, 13.4 g), toluene (100 g) and two crystals of chloroplatinic acid. The solution was stirred and refluxed for 3 hours to complete the hydrosilation. After cooling to room temperature, BHT (200 ppm) was added to the flask along with allylmethacrylate (38 mmol, 4.8 g). A gas dispersion tube was inserted into the flask and a small amount of air was bubbled into the stirred solution, while heating to 80C for 2 hours to complete the hydrosilation. The cooled solution was filtered through 1O g of silica gel, and after removal of the solvent 27 g of a viscous clear liquid was collected. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
A 500-mL round-bottomed flask equipped with a Teflon-coated stir bar and a reflux condenser was charged with 24.0 g (400 mmol Si-H) of tetramethylcyclosiloxane. To the flask was added 4-vinyl-1-cyclohexene-1,2-epoxide (200 mmol 24.8 g), toluene (200 g), and two crystals of chloroplatinic acid. The solution was stirred and refluxed for 3 hours to complete the hydrosilation. After cooling to room temperature, vinyl-triethoxysilane (200 mmol, 38.0 g) was added to the flask and the solution was refluxed again for an additional 3 hours to complete the hydrosilation. After cooling down to room temperature, the solution was filtered through 10 g of silica gel to decolorize; stripping off the solvent afforded 82 g of a thick clear resin. | ||
Example 15; A 500-mL round-bottomed flask equipped with a Teflon-coated stir bar and a reflux condenser was charged with 24.0 g (400 mmol Si-H) of tetramethylcyclosiloxane. To the flask was added vinyl cyclohexene-oxide (200 mmol 24.8 g), toluene (200 g), and two crystals of chloroplatinic acid. The solution was stirred and refluxed for 3 hours to complete the hydrosilation. After cooling to room temperature, vinyl-triethoxysilane (200 mmol, 38.0 g) was added to the flask and the solution was refluxed again for an additional 3 hours to complete the hydrosilation. After cooling down to room temperature, the solution was filtered through 1O g of silica gel to decolorize; stripping off the solvent afforded 82 g of a thick clear resin. |