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Structure of 236406-39-6

Chemical Structure| 236406-39-6

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Product Details of [ 236406-39-6 ]

CAS No. :236406-39-6
Formula : C13H24N2O2
M.W : 240.34
SMILES Code : O=C(N(CC1)CCC21CCNC2)OC(C)(C)C
MDL No. :MFCD09608078
InChI Key :MGHFVXFMQGQAKJ-UHFFFAOYSA-N
Pubchem ID :23282900

Safety of [ 236406-39-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 236406-39-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 236406-39-6 ]

[ 236406-39-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 236406-39-6 ]
  • [ 60211-57-6 ]
  • [ 530-62-1 ]
  • C21H28Cl2N2O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
To a solution of the benzyl alcohol (starting material 2, 1 mmol) in dichloromethane (5 ml) was added Nu,Nu'-carbonyldiimidazole (1.05 mmol) at room temperature. The mixture was stirred for 3 h at ambient temperature, followed by addition of the spirocyclic amine (starting material 1, 1 mmol) and triethylamine (1 mmol). Then after 18 h the reaction mixture was partitioned between dichloromethane and brine. The organic layer was washed with brine, dried over magnesium sulfate, filtered and evaporated in vacuo. The residue was chromatographed on silica gel, using a heptane/ethyl acetate gradient, producing the benzyl carbamate intermediate as a colorless oil.
To a solution of the benzyl alcohol (starting material 2, 1 mmol) in dichloromethane (5 ml) was added N,N?-carbonyldiimidazole (1.05 mmol) at room temperature. The mixture was stirred for 3 h at ambient temperature, followed by addition of the spirocyclic amine (starting material 1, 1 mmol) and triethylamine (1 mmol). Then after 18 h the reaction mixture was partitioned between dichloromethane and brine. The organic layer was washed with brine, dried over magnesium sulfate, filtered and evaporated in vacuo. The residue was chromatographed on silica gel, using a heptane/ethyl acetate gradient, producing the benzyl carbamate intermediate as a colorless oil.
 

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