Home Cart Sign in  
Chemical Structure| 232275-49-9 Chemical Structure| 232275-49-9

Structure of 232275-49-9

Chemical Structure| 232275-49-9

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 232275-49-9 ]

CAS No. :232275-49-9
Formula : C8H7Cl2NO2
M.W : 220.05
SMILES Code : O=C(OC)C1=C(Cl)C=C(N)C=C1Cl
MDL No. :MFCD22493408

Safety of [ 232275-49-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 232275-49-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 232275-49-9 ]

[ 232275-49-9 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 232275-49-9 ]
  • [ 232275-53-5 ]
YieldReaction ConditionsOperation in experiment
With copper; sodium nitrite; In aq. HBr; 1) 4-Amino-2,6-dichlorobenzoic acid methyl ester (1.00 g) was suspended in 40% aq. HBr and the mixture was cooled 1 to 0-5 C. After NaNO2 (376 mg) was added in small portions, the mixture was stirred for about 5 min. Copper (100 mg) was added and the mixture was warmed up to 100 C. The mixture was then stirred at 100 C. for 30 min, diluted with water and extracted with AcOEt. The extract was dried (MgSO4), filtered and evaporated. The residue was purified by column chromatography (silica gel; eluent: hexane and AcOEt 50:1) to give 4-bromo-2,6-dichlorobenzoic acid methyl ester (1.07 g).
  • 3
  • [ 50-43-1 ]
  • [ 232275-49-9 ]
  • 4
  • [ 232275-49-9 ]
  • C8H4Br2Cl2O2 [ No CAS ]
  • [ 232275-53-5 ]
YieldReaction ConditionsOperation in experiment
Take the crude compound obtained from the previous step (220 mg, lmmol) was added to 48% hydrobromic acid (20 mL), dissolved in a slight heat, and then cooled to a temperature range of -10 to 5 C. A white powder was precipitated and the sodium nitrite (76 mg, 1. Lmmol) and the reaction temperature was controlled below -5 C during the addition. After adding, the mixture was stirred for 1 h, then the cuprous bromide powder (144 mg, lmmol) was added. After the addition, the temperature was gradually raised to the reflux temperature and reacted at reflux temperature for 1 to 2 hours. After the end of the reaction, the ethyl acetate was extracted and the organic layer was washed with saturated sodium carbonate, washed with brine, dried over anhydrous sodium sulfate and separated by column chromatography to obtain a monobromine and bisbromide mixture (150 mg). The silica gel column was difficult to separate
 

Historical Records

Technical Information

Categories