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Chemical Structure| 23180-57-6 Chemical Structure| 23180-57-6
Chemical Structure| 23180-57-6

Paeoniflorin

CAS No.: 23180-57-6

Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.

Synonyms: Peoniflorin; NSC 178886

4.5 *For Research Use Only !

Cat. No.: A494257 Purity: 98%

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Product Details of Paeoniflorin

CAS No. :23180-57-6
Formula : C23H28O11
M.W : 480.46
SMILES Code : O[C@H]1[C@H](O)[C@@H](O)[C@]([H])(O[C@]2([C@@]3(C)O[C@]4([H])O[C@@]5(C3)O)C[C@]5([H])[C@]24COC(C6=CC=CC=C6)=O)O[C@@H]1CO
Synonyms :
Peoniflorin; NSC 178886
MDL No. :MFCD00869331
InChI Key :YKRGDOXKVOZESV-WRJNSLSBSA-N
Pubchem ID :442534

Safety of Paeoniflorin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description Reference
A549 cells 1 –30 μM 24 hours Paeoniflorin significantly attenuated TGF-β1-induced expression of Snail and activation of Smad2/3, but slightly affected TGF-β1-induced activation of Akt, ERK, JNK and p38 MAPK. Moreover, paeoniflorin markedly increased Smad7 level, and decreased ALK5 level. PMC4954768

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description Reference
ICR mice Bleomycin-induced pulmonary fibrosis model Oral 50, 100 mg/kg Once daily for 21 days Paeoniflorin significantly decreased the expression of FSP-1 and α-SMA, and increased the expression of E-cadherin in lung tissues. PMC4954768

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.08mL

0.42mL

0.21mL

10.41mL

2.08mL

1.04mL

20.81mL

4.16mL

2.08mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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