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Chemical Structure| 23145-19-9 Chemical Structure| 23145-19-9

Structure of 23145-19-9

Chemical Structure| 23145-19-9

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Product Details of [ 23145-19-9 ]

CAS No. :23145-19-9
Formula : C10H8O3
M.W : 176.17
SMILES Code : COC1=CC=C2OC(C=O)=CC2=C1
MDL No. :MFCD01413839
InChI Key :OPAYERWEZXLSFC-UHFFFAOYSA-N
Pubchem ID :31663

Safety of [ 23145-19-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 23145-19-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 23145-19-9 ]

[ 23145-19-9 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 1123-93-9 ]
  • [ 23145-19-9 ]
  • [ 4712-55-4 ]
  • diphenyl (benzo[d]thiazol-5-ylamino)(5-methoxybenzofuran-2-yl)methylphosphonate [ No CAS ]
YieldReaction ConditionsOperation in experiment
95% With hydrogen trititanate; In neat (no solvent); at 20℃; for 0.25h;Green chemistry;Catalytic behavior; General procedure: Dialkyl/diaryl phosphite (1.0 mmol) was added portion wise over a period of 5 min to the stirred mixture of heterocyclic aldehyde (1.0 mmol) and benzothiazole amine (1.0 mmol) at room temperature. Further 5 mol percent of TNT was added to the reaction mixture and the stirring was continued for 15 min. After the completion of the reaction as monitored through TLC, the reaction mixture was dissolved in EtOAc (2 mL) and the catalyst was separated by centrifugation followed by subsequent washings with EtOAc. The recovered catalyst was reused for the next cycle. The filtrate was washed with brine, dried over anhydrous Na2SO4, filtered, and concentrated on a rotary evaporator and the resulting residue was purified by silica gel column chromatography (70:30, hexane/EtOAc) to afford the corresponding pure alpha-aminophosphonate. The novel alpha-aminophosphonates were structurally assigned by their IR, NMR (1H, 13C & 31P), and mass spectral (HRMS) analyses.
  • 2
  • [ 23145-19-9 ]
  • [ 42182-27-4 ]
  • 3-(dimethylamino)-2-(5-methoxy-1-benzofuran-2-yl)imidazo[1,2-a]pyridine-7-carbonitrile [ No CAS ]
  • 3
  • [ 23145-19-9 ]
  • [ 593-75-9 ]
  • [ 42182-27-4 ]
  • 2-(5-methoxy-1-benzofuran-2-yl)-3-(methylamino)imidazo[1,2-a]pyridine-7-carbonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
46% With acetic acid; In methanol; at 20℃; for 72h; 5-Methoxy-l-benzofuran-2-carbaldehyde (300 mg, 1.70 mmol) and 2- aminoisonicotinonitrile (203 mg, 1.70 mmol) were dissolved in methanol (10 mL). Acetic acid (1 mL) and methyl isocyanide (76 mu, 1.70 mmol) were added and the mixture stirred at room temperature. After 3 days the reaction mixture was filtered and the yellow precipitate washed with methanol (3 x 10 mL) and dried under suction to give the title compound 256 mg (46percent yield) as an orange powder. deltaEtaNMR (500 MHz, DMSO) 8.41 (d, J = 7.15 Hz, 1H), 8.22 (br. s, 1H), 7.54 (d, J = 8.89 Hz, 1H), 7.25 (s, 1H), 7.20 (d, J = 2.56 Hz, 1H), 7.18 (dd, J = 1.56, 7.15 Hz, 1H), 6.91 (dd, J = 2.61, 8.89 Hz, 1H), 5.43 (q, J = 5.44 Hz, 1H), 3.81 (s, 3H), 2.89 (d, J = 5.46 Hz, 3H). Tr(METCR1278) = 1.94 min, (ES+) (M+H)+ 319.
 

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Technical Information

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[ 23145-19-9 ]

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