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Chemical Structure| 2295-58-1 Chemical Structure| 2295-58-1
Chemical Structure| 2295-58-1

Flopropione

CAS No.: 2295-58-1

Flopropione is both a 5-HT1A receptor antagonist and a COMT inhibitor as a spasmolytic or antispasmodic agent.

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Cat. No.: A379901 Purity: 99%

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Product Details of Flopropione

CAS No. :2295-58-1
Formula : C9H10O4
M.W : 182.17
SMILES Code : CCC(C1=C(O)C=C(O)C=C1O)=O
MDL No. :MFCD00016456
InChI Key :PTHLEKANMPKYDB-UHFFFAOYSA-N
Pubchem ID :3362

Safety of Flopropione

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P305+P351+P338

Related Pathways of Flopropione

GPCR

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description Reference
HEK293 cells 50 μM Reduced single-channel open probability to 0.17 PMC10828444
HEK293 cells 100 μM Inhibited TRPV3 currents by approximately 84% PMC10828444
Fisher rat thyroid (FRT) monolayers 23 μM (IC50) Doxapram inhibits rat TASK-3 potassium channel function PMC3865919
Fisher rat thyroid (FRT) monolayers 1.6 μM (IC50) A1899 inhibits rat TASK-3 potassium channel function PMC3865919
Fisher rat thyroid (FRT) monolayers 42 nM (IC50) PK-THPP inhibits rat TASK-3 potassium channel function PMC3865919

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description Reference
C57BL/6J mice DNFB-induced skin inflammation model Topical application 0.1–10 mM Once daily for four consecutive days Alleviated skin inflammation and injury PMC10828444

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.49mL

1.10mL

0.55mL

27.45mL

5.49mL

2.74mL

54.89mL

10.98mL

5.49mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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