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Chemical Structure| 228245-16-7 Chemical Structure| 228245-16-7
Chemical Structure| 228245-16-7

tert-Butyl N-(3-aminopropoxy)carbamate

CAS No.: 228245-16-7

4.5 *For Research Use Only !

Cat. No.: A368728 Purity: 95%

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Eman A. Akam-Baxter ; David Bergemann ; Sterling J. Ridley ; Samantha To ; Brittany Andrea ; Brianna Moon , et al.

Abstract: In mammalian hearts myocardial infarction produces a permanent collagen-rich scar. Conversely, in zebrafish a collagen-rich scar forms but is completely resorbed as the myocardium regenerates. The formation of cross-links in collagen hinders its degradation but cross-linking has not been well characterized in zebrafish hearts. Here, a library of to quantify collagen , the first step in collagen cross-link (CCL) formation, was developed. Myocardial injury in mice or zebrafish resulted in similar dynamics of collagen in the myocardium in the first month after injury. However, during this time, mature CCLs such as pyridinoline and deoxypyridinoline developed in the murine infarcts but not in the zebrafish hearts. High levels of newly oxidized collagen were still seen in murine scars with mature CCLs. These data suggest that fibrogenesis remains dynamic, even in mature scars, and that the absence of mature CCLs in zebrafish hearts may facilitate their ability to regenerate.

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Akam, Eman A ; Bergemann, David ; Ridley, Sterling J ; To, Samantha ; Andrea, Brittany ; Moon, Brianna , et al.

Abstract: In mammalian hearts myocardial infarction produces a permanent collagen-rich scar. Conversely, in zebrafish a collagen-rich scar forms but is completely resorbed as the myocardium regenerates. The formation of cross-links in collagen hinders its degradation but cross-linking has not been well characterized in zebrafish hearts. Here, a library of fluorescent probes to quantify collagen oxidation, the first step in collagen cross-link (CCL) formation, was developed. Myocardial injury in mice or zebrafish resulted in similar dynamics of collagen oxidation in the myocardium in the first month after injury. However, during this time, mature CCLs such as pyridinoline and deoxypyridinoline developed in the murine infarcts but not in the zebrafish hearts. High levels of newly oxidized collagen were still seen in murine scars with mature CCLs. These data suggest that fibrogenesis remains dynamic, even in mature scars, and that the absence of mature CCLs in zebrafish hearts may facilitate their ability to regenerate.

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Product Details of [ 228245-16-7 ]

CAS No. :228245-16-7
Formula : C8H18N2O3
M.W : 190.24
SMILES Code : O=C(OC(C)(C)C)NOCCCN
MDL No. :MFCD20701870

Safety of [ 228245-16-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H315-H318-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P312-P332+P313-P362-P403+P233-P405-P501
Class:8
UN#:3267
Packing Group:
 

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