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Chemical Structure| 227752-10-5 Chemical Structure| 227752-10-5

Structure of 227752-10-5

Chemical Structure| 227752-10-5

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Product Details of [ 227752-10-5 ]

CAS No. :227752-10-5
Formula : C11H16N2O3
M.W : 224.26
SMILES Code : O=C(C[C@@H](C1=CC=C(N=C1)OC)N)OCC
MDL No. :MFCD29076302

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Application In Synthesis of [ 227752-10-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 227752-10-5 ]

[ 227752-10-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1211526-53-2 ]
  • [ 76-05-1 ]
  • [ 227752-10-5 ]
  • (S)-tert-butyl 6-((3-ethoxy-1-(6-methoxypyridin-3-yl)-3-oxopropyl)carbamoyl)-2-azaspiro[3.3]heptane-2-carboxylate trifluoroacetic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
83% To a mixture of 2-(Yer/-butoxycarbonyl)-2- azaspiro[3.3]heptane-6-carboxylic acid (100 mg, 0.414 mmol) and Intermediate 11 (93 mg, 0.414 mmol) in DMF (1 niL) under Ar was added BOP (275 mg, 0.622 mmol) followed by DIPEA (0.217 mL, 1.243 mmol) . The reaction was stirred at room temperature for 1.5 h. The mixture was purified by preparative HPLC (Phenomenex Luna Axia 5mu C18 30 x 100 mm; 10 min gradient from 30% A: 70% B to 0% A: 100% B (A = 90% H2O/IO % MeOH + 0.1% TFA); (B = 90% MeOH/10% H2O + 0.1% TFA);detection at 220 nm) to yield E2A (194 mg, 83%). LCMS (ES): m/z 448.4 [M+H]+.
 

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