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Chemical Structure| 226398-62-5 Chemical Structure| 226398-62-5

Structure of 226398-62-5

Chemical Structure| 226398-62-5

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Product Details of [ 226398-62-5 ]

CAS No. :226398-62-5
Formula : C16H22BrNO4S
M.W : 404.32
SMILES Code : CC(C)(C)OC(=O)N1CCC(CC1)S(=O)(=O)C1=CC=C(Br)C=C1
MDL No. :MFCD06657079

Safety of [ 226398-62-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 226398-62-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 226398-62-5 ]

[ 226398-62-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1003-61-8 ]
  • [ 226398-62-5 ]
  • [ 936845-87-3 ]
YieldReaction ConditionsOperation in experiment
27% With caesium carbonate;tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; at 160℃; for 0.25h;Irradiation; In a dry 15mL microwave vial were combined 2-amino-thiazole-5-carbaldehyde (0.354 g, 2.77 mmol), intermediate 25 (1.23 g, 3.04 mmol), cesium carbonate (2.7 g, 8.29 mmol), Xantphos (0.32 g, 0.55 mmol) and tris(dibenzylideneacetone) dipalladium (0.25 g, 0.28 mmol). Reactants were diluted with dioxane (12 mL), flushed with argon and irradiated for 15 min at 160 0C. Reaction was then diluted with EtOAc, decanted and washed with water followed by brine. Organic phase cut from aqueous layer, dried over sodium sulfate, filtered and evaporated to dark oil. Crude product was purified via silica gel chromatography. The title intermediate was isolated as pale yellow solids (0.34 g, 27%).
 

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