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Chemical Structure| 2216-12-8 Chemical Structure| 2216-12-8

Structure of 2216-12-8

Chemical Structure| 2216-12-8

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Product Details of [ 2216-12-8 ]

CAS No. :2216-12-8
Formula : C12H9NO3
M.W : 215.20
SMILES Code : O=[N+](C1=CC=CC=C1OC2=CC=CC=C2)[O-]
MDL No. :MFCD00035744

Safety of [ 2216-12-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315
Precautionary Statements:P280

Application In Synthesis of [ 2216-12-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2216-12-8 ]

[ 2216-12-8 ] Synthesis Path-Downstream   1~3

  • 2
  • [ 1095-03-0 ]
  • [ 15163-59-4 ]
  • [ 2216-12-8 ]
YieldReaction ConditionsOperation in experiment
48% With oxygen; copper diacetate; silver carbonate; In N,N-dimethyl-formamide; at 145℃; for 18h; General procedure: A 20 mL crimp-cap reaction vessel was charged with the potassium carboxylate (1a-k) (1.00 mmol), silver carbonate (69 mg, 0.25 mmol), copper(II) acetate (182 mg, 1 mmol) and the silane (2a-f) (1.2 mmol). Anhydrous DMF (5 mL) was added to it, the reaction vessel was briefly purged with oxygen, and the resulting mixture was stirred at 145C for 18 h at ambient oxygen pressure. After cooling to room temperature, the reaction mixture was diluted with diethyl ether (20 mL) and washed with saturated aqueous sodium bicarbonate (20 mL). The aqueous layer was extracted with diethyl ether (3 x 20 mL), and the organic layers were washed with water, 5 N HCl and brine, dried over MgSO4, filtered, and concentrated in vacuum. The residue was purified by column chromatography (silica gel, n-hexane) to yield the corresponding aryl ether (3aa...3ka). All the scale-up reactions were carried out in 50 mL vessels.
  • 3
  • [ 2216-12-8 ]
  • [ 26608-06-0 ]
 

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