Home Cart Sign in  
Chemical Structure| 22158-41-4 Chemical Structure| 22158-41-4

Structure of 22158-41-4

Chemical Structure| 22158-41-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 22158-41-4 ]

CAS No. :22158-41-4
Formula : C10H7NO3
M.W : 189.17
SMILES Code : O=C1C(N)=C(O)C(C2=C1C=CC=C2)=O
MDL No. :MFCD00184327

Safety of [ 22158-41-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P280

Application In Synthesis of [ 22158-41-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 22158-41-4 ]

[ 22158-41-4 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 22158-41-4 ]
  • [ 707-07-3 ]
  • [ 63388-44-3 ]
YieldReaction ConditionsOperation in experiment
65% at 90℃; for 2 h; 2-phenylnaphtho[2,3-d]oxazole-4,9-dione (A)
Intermediate 3 (500 mg, 1.0 eq), trimethylorthobenzoate (3.6 mL, 8.0 eq) and PPTS (66 mg, 0.1 eq) were combined and heated at 90° C. (oil bath) for 2 hours at which point LC-MS analysis indicated complete consumption of starting material.
The reaction mixture was diluted with Et2O and the resulting yellow ppt collected and washed with Et2O and EtOAc and dried to yield desired product (472 mg, 65percent) as a bright yellow fluffy solid. 1H NMR (400 MHz, CDCl3): δ 7.53-7.62 (3H, M), 7.81 (2H, dd, J=3.5, 5.9), 8.25 (1H, dd, J=3.3, 5.7), 8.29 (1H, dd, J=3.1, 5.9), 8.31-8.34 (2H, M). LRMS (M+H)+: 276.19.
References: [1] Heterocyclic Communications, 2002, vol. 8, # 2, p. 199 - 204.
[2] Patent: US9725425, 2017, B1, . Location in patent: Page/Page column 104; 105.
  • 2
  • [ 22158-41-4 ]
  • [ 98-88-4 ]
  • [ 63388-44-3 ]
  • [ 474433-63-1 ]
References: [1] Heterocyclic Communications, 2002, vol. 8, # 2, p. 199 - 204.
 

Historical Records

Technical Information

Categories