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CAS No. : | 22123-14-4 |
Formula : | C7H5ClF3N |
M.W : | 195.57 |
SMILES Code : | CC1=CC(=CC(Cl)=N1)C(F)(F)F |
MDL No. : | MFCD00052900 |
InChI Key : | SXLBWNSGCIEART-UHFFFAOYSA-N |
Pubchem ID : | 2736626 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Num. heavy atoms | 12 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.29 |
Num. rotatable bonds | 1 |
Num. H-bond acceptors | 4.0 |
Num. H-bond donors | 0.0 |
Molar Refractivity | 39.21 |
TPSA ? Topological Polar Surface Area: Calculated from | 12.89 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from | 2.07 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by | 3.1 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from | 4.21 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from | 2.49 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by | 3.44 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions | 3.06 |
Log S (ESOL):? ESOL: Topological method implemented from | -3.31 |
Solubility | 0.0959 mg/ml ; 0.00049 mol/l |
Class? Solubility class: Log S scale | Soluble |
Log S (Ali)? Ali: Topological method implemented from | -3.04 |
Solubility | 0.179 mg/ml ; 0.000915 mol/l |
Class? Solubility class: Log S scale | Soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by | -3.92 |
Solubility | 0.0236 mg/ml ; 0.000121 mol/l |
Class? Solubility class: Log S scale | Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg | High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg | Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) | No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) | Yes |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) | No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) | No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) | No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) | No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from | -5.29 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from | 0.0 |
Ghose? Ghose filter: implemented from | None |
Veber? Veber (GSK) filter: implemented from | 0.0 |
Egan? Egan (Pharmacia) filter: implemented from | 0.0 |
Muegge? Muegge (Bayer) filter: implemented from | 2.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat | 0.55 |
PAINS? Pan Assay Interference Structures: implemented from | 0.0 alert |
Brenk? Structural Alert: implemented from | 1.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from | No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) | 1.76 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 16h;Heating / reflux; | 2-(bromomethyl)-6-chloro-4-(trifluoromethyl)pyridine. (<strong>[22123-14-4]2-chloro-6-methyl-4-(trifluoromethyl)pyridine</strong> (10.0 g, 51 mmol), N-bromosuccinimide (10.9 g, 61 mmol), and 2,2'-azobis(2-methylpropionitrile) (164mg, 1 mmol) were combined in carbon tetrachloride (200 mL) and heated to reflux. After 16 h, the reaction mixture was cooled to 0 C. and filtered. The filtrate was concentrated and purified by column chromatography on silica gel (100% hexanes) to produce 9.1 g (70%) as a light yellow oil. 1H-NMR (CDCl3, 400 MHz) delta7.59 (s, 1H), 7.47 (s, 1H), 4.52 (s, 2H). |
70% | With N-Bromosuccinimide;2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 16h;Reflux; | (2-chloro-6-methyl-4- (trifluoromethyl)pyridine (10.0 g, 51 mmol), N-bromosuccinimide (10.9 g, 61 mmol), and 2,2'-azobis(2-methylpropionitrile) (164mg, 1 mmol) were combined in carbon tetrachloride (200 mL) and heated to reflux. After 16 h, the reaction mixture was cooled to 0C and filtered. The filtrate was concentrated and purified by column chromatography on silica gel (100% hexanes) to produce 9.1 g (70%) as a light yellow oil. 1H-NMR (CDCl3, 400 MHz) delta 7.59 (s, IH), 7.47 (s, IH), 4.52 (s, 2H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
51% | With selenium(IV) oxide; In 1,2-dichloro-benzene; at 180℃; for 3h; | 6-hydroxy-4-(trifluoromethyl)picolinaldehyde. <strong>[22123-14-4]2-chloro-6-methyl-4-(trifluoromethyl)pyridine</strong> (2.0 g, 10.2 mmol) and selenium dioxide (3.5 g, 30.6 mmol) were dissolved in dichlorobenzene (40 ml) and heated to 180 C. and mixed for 3 hours. The reaction mixture was allowed to cool to room temperature. The precipitate was removed via vacuum filtration. Column chromatography on silica gel (10% -70% ethyl acetate/hexanes) afforded 1.00 g desired product (51%) 1HNMR (CDCl3 400MHz) delta9.58 (s, 1H), 7.13 (s, 1H), 6.87 (s, 1H). |
51% | With selenium(IV) oxide; In 1,2-dichloro-benzene; at 180℃; for 3h; | 2-chloro-6-methyl-4- (trifluoromethyl)pyridine (2.0 g, 10.2 mmol) and selenium dioxide (3.5 g, 30.6 mmol) were dissolved in dichlorobenzene (40 ml) and heated to 1800C and mixed for 3 hours. The reaction mixture was allowed to cool to room temperature. The precipitate was removed via vacuum filtration. Column chromatography on silica gel (10% - 70% ethyl acetate / hexanes) afforded 1.00 g desired product (51%) 1HNMR (CDCl3 400MHz) delta 9.58 (s, IH), 7.13 (s, IH), 6.87 (s, IH). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70.2% | With triethylamine; In 1,4-dioxane; at 100℃; for 5h; | A solution of <strong>[22123-14-4]2-chloro-6-methyl-4-(trifluoromethyl)pyridine</strong> (1.0 g, 5.11 mmol), piperazine (1.32 g, 15.3 mmol), and triethylamine (0.71 mL, 5.1 mmol) were mixed in 1,4-dioxane (10 mL). After stirring at 100 C. for 5 h, the reaction solution was diluted with water and extracted with ethyl acetate three times, dried with sodium sulfate, filtered, and concentrated in vacuo. The crude residue was purified by flash column chromatography (10% MeOH/5% Et3N/EtOAc) to yield the desired product (880 mg, 70.2%). LCMS calculated for C11H15F3N3: (M+1) 246.1; found 246.1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
The following may be mentioned as examples of pyridine derivatives of the formula (IV): ... 2-chloro-4,6-dimethyl-pyridine 2-fluoro-4,6-dimethyl-pyridine 2-chloro-6-methyl-4-propyl-pyridine 2-chloro-6-methyl-4-isopropyl-pyridine 2-chloro-6-methyl-4-trifluoromethyl-pyridine 2,3-dichloro-4,6-dimethyl-pyridine 2-chloro-5-fluoro-4,6-dimethyl-pyridine 2-chloro-3-cyano-4,6-dimethyl-pyridine ... |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
A. 2-(2-Dimethylaminoethylamino)-4-trifluoromethyl-6-methylpyridine The title compound is obtained by following the procedure of Example 38, Part A except substituting <strong>[22123-14-4]2-chloro-4-trifluoromethyl-6-methylpyridine</strong> for 2,6-dichloropyridine. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
44% | With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 3h;Heating / reflux; | Procedure B; Step A; A solution of 2-chloro-6-methyl-4-trifluoromethyl pyridine (21.18 g, 108.3 mmol, Maybridge CD 10452), N-bromosuccinimide (21.20 g, 119.2 mmol, Aldrich) in tetrachloromethane (200 mL) was stirred at gentle reflux while a solution of 2,2'-azobisisobutyronitrile (1.87 mL) in tetrachloromethane (50 mL) was added, drop wise. Heating was continued for three hours, after which time the reaction mixture was allowed to cool to room temperature, washed with water (4×100 mL), dried with anhydrous magnesium sulfate and evaporated to dryness. The crude product (34 g) was purified on a Silica gel column using ethyl acetate/hexane mixture with the concentration of ethyl acetate gradually rising from 0% to 5% at the end of the separation. In this manner it was obtained: 9.6 g of 2-(alpha,alpha-dibromomethyl)-6-chloro-4-trifluoromethyl pyridine, 13.1 g of the desired 2-(alpha-bromomethyl)-6-chloro-4-trifluoromethyl pyridine (44%) and 9.03 g of unreacted starting material. 2-(alpha,alpha-Dibromomethyl)-6-chloro-4-trifluoromethyl pyridine: 1H NMR (500 MHz, CDCl3): 7.95 (s, 1H), 7.53 (s, 1H), 6.62 (s, 1H). 2-(alpha-Bromomethyl)-6-chloro-4-trifluoromethyl pyridine: 1H NMR (500 MHz, CDCl3): 7.62 (s, 1H), 7.51 (s, 1H), 4.55 (s, 2H). |
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; at 90℃; | To a solution of <strong>[22123-14-4]2-chloro-6-methyl-4-(trifluoromethyl)pyridine</strong> (1.514 ml, 10.2 mmol) in CC14 (30 ml) was added BS (2730 mg, 15.3 mmol) and AIBN (168 mg, 1.02 mmol) and the resulting mixture was stirred at 90 C overnight, then filtered and the solution was evaporated and purified via silica gel chromatography (0 - 10 % EtOAc in hexanes to give a mixture of 2-chloro-6- methyl-4-(trifluoromethyl)pyridine, 2-(bromomethyl)-6-chloro-4-(trifluoromethyl)pyridine and 2-chloro-6-(dibromomethyl)-4-(trifluoromethyl)pyridine (1812 mg, 3.30 mmol, 32% yield, -50% monobromo) as an orange liquid. MS (ES+) C7H4BrClF3N requires: 274, found: 274, 276 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
67% | With tetra-n-butylammonium permanganate; In pyridine; at 80℃; for 3h; | To a solution of 300 mg of <strong>[22123-14-4]2-chloro-6-methyl-4-(trifluoromethyl)-pyridine</strong> (1.49 mmol) in pyridine (5 ml) was added a solution of 1.61 g of tetrabutylammonium permanganate (4.46 mmol) in pyridine (4.5 ml) and the reaction mixture was stirred at 80 C. for 3 h. The reaction mixture was then poured into a mixture of water and ice and then NaHSO3 solution (40% in water) was added until the color turned light yellow. The mixture was then acidified by addition of 2N HCl and extracted with ethyl acetate. The combined organic layers were then washed with 1N HCl and brine, dried (Na2SO4), filtered and concentrated. The remaining residue was purified by chromatography (DCM/MeOH 100:0 to 90:10) to yield 224 mg (67%) of a gray liquid. MS (ISP) 224.3 (M-H)-. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrazine; In ethanol;Heating / reflux; | One equivalent of <strong>[22123-14-4]2-chloro-4-(trifluoromethyl)-6-methylpyridine</strong> (13) and 1.5 equivalent of hydrazine hydrate were mixed in ethanol. The solution turned yellow after being stirred for several minutes. The reaction mixture was refluxed until TLC analysis showed no starting material left. The solvent was then removed under vacuum, and the resulting slurry was extracted with ether three times. The combined ether solution was dried over anhydrous MgSO4 and evaporated to afford the crude product, which was then re-crystallized from ethanol to give compound 14. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-ethyl-N,N-diisopropylamine; In diethylene glycol; at 140℃; for 2h;microwave reaction; | Reference Example 29: Synthesis of (S)-N-(1-benzylpyrrolidin-3-yl)-6-methyl-4-trifluoromethylpyridin-2-amine A mixture of <strong>[22123-14-4]2-chloro-6-methyl-4-trifluoromethylpyridine</strong> (0.196 g), (S)-1-benzyl-3-aminopyrrolidine (0.529 g), diethylene glycol (4 mL), and N,N-diisopropylethylamine (0.52 mL) was heated at 140C for 2 h using a microwave reaction apparatus. After completion of the reaction, water and ethyl acetate were added to the reaction solution, the mixture was extracted with ethyl acetate, washed with saturated brine, and then dried with anhydrous magnesium sulfate, then the desiccant was removed by filtration, and then the crude product obtained by concentration under reduced pressure was purified by silica gel column chromatography (silica gel, hexane/ethyl acetate = 5:1-2:1) to obtain (S)-N-(1-benzylpyrrolidin-3-yl)-6-methyl-4-trifluoromethylpyridin-2-amine (0.082 g). 1H-NMR (300 MHz, DMSO-d6): delta7.20-7.34 (m, 5H), 6.60 (s, 1H), 6.32 (s, 1H), 5.01 (d, J=8.00 Hz, 1H), 4.20-4.30 (m, 1H), 3.63 (d, J=5.8 Hz, 2H), 2.75-2.85 (m, 2H), 2.50-2.60 (m, 1H), 2.40 (s, 3H), 2.30-2.50 (m, 2H), 1.60-1.70 (m, 1H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With ammonia; at 120℃; for 24h; | A mixture of 4.7 g <strong>[22123-14-4]2-chloro-6-methyl-4-trifluoromethyl-pyridine</strong> and 80 g ammonia was heated in an autoclave at 120 C. for 24 h. Ammonia was allowed to evaporate and the residue was purified on silica gel with methylene chloride:methanol:ammonia=9:1:0.1 to yield 4.01 g of the title compound as off white crystals MS (ISP) M+H+=177.1 melting at 53.5-54.5 C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
tetrakis(triphenylphosphine) palladium(0); In N,N-dimethyl-formamide; at 90℃; for 10h; | <Reference Production Example 20>To 10 ml of N,N-dimethylformamide were added 1 g of 2-chloro-6-methyl-4- trifluoromethylpyridine, 1.2 g of zinc cyanide and 0.24 g of tetrakistriphenylphosphinepalladium, and the mixture was stirred at 900C for 10 hours.After allowing to cool, the reaction solution was poured into water, and the resultant solution was extracted with diethyl ether three times, washed with an aqueous saturated sodium chloride solution, dried with anhydrous magnesium sulfate, and concentrated.The residue was subjected to silica gel column chromatography to obtain 0.8 g of 6- methyl-4-trifluoromethylpyridine-2-carbonitrile.6-Methyl-4-trifluoromethylpyridine-2-carbonitrile1H-NMR: 2.72 (s, 3H), 7.60 (s, IH), 7.72 (s, IH) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61% | iron(III) chloride; In tetrahydrofuran; at 20℃; for 2h;Inert atmosphere; | Synthesis Example 2 In the same manner as in Synthesis Example 1, except for using 4.65 g (0.0215 mol) of 2,6-dichloro-4-trifluoromethylpyridine and using 7.5 mL of a tetrahydrofuran solution of 3.0 mol/L of methylmagnesium chloride (containing 0.0226 mol of MeMgCl) as the Grignard reagent, 2.67 g (purity: 95.3%, yield: 61%) of 2-chloro-6-methyl-4-trifluoromethylpyridine was obtained. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
73% | iron(II) chloride; In tetrahydrofuran; at 20℃; for 2h;Inert atmosphere;Product distribution / selectivity; | Synthesis Example 3 In the same manner as in Synthesis Example 1, except for using 4.61 g (0.0213 mol) of 2,6-dichloro-4-trifluoromethylpyridine and using 15 mg of iron(II) chloride as a metal catalyst, 3.16 g (purity: 96.6%, yield: 73%) of 2-chloro-6-methyl-4-trifluoromethylpyridine was obtained. |
62.4% | With iron(III) chloride; In tetrahydrofuran; at 0 - 25℃; for 2h;Inert atmosphere; | The 2,6-dichloro-4 - (trifluoromethyl) pyridine (10.8g, 50mmol) dissolved in tetrahydrofuran (100 ml) in, adding anhydrous ferric trichloride (0.811g, 5mmol), under the protection of nitrogen, 0 C lower dropwise methyl bromide of magnesium oxide (1mol/L ether solution, 50 ml, 50mmol), the temperature is increased to 25 C stirring 2 hours, water (100 ml), ethyl acetate extraction (150 ml × 2), combined organic phase, dried anhydrous sodium sulfate, concentrated under vacuum, to get the yellow oily title compound (6.1g, yield 62.4%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene;bis-triphenylphosphine-palladium(II) chloride; tri-tert-butyl phosphine; In N,N-dimethyl-formamide; at 150℃; for 0.166667h;microwave irradiation; Inert atmosphere; | In a microwave vial 1,1-dimethylethyl (lR,4S,6R)-4-ethynyl-3-azabicyclo[4.1.0]heptane-3- carboxylate D5 (250 mg), 2-chloro-6-m ethyl -4-(trifluoromethyl)pyri dine (221 mg, 1.130 mmol), Cs2C03 (368 mg, 1.130 mmol), bis(triphenylphosphine)palladium(II) chloride (15.86 mg, 0.023 mmol), tri-t-butylphosphine (10.96 mu, 0.045 mmol) and DBU (14 mu, 0.093 mmol) were dissolved in DMF (4 ml). The vial was sealed under nitrogen and the mixture was irradiated for 10 minutes at 150 C.The reaction mixture was cooled to 23 C, diluted with EtOAc (30 ml) and filtered through a Celite pad. The filtrate was washed with brine (3 x 20 ml) and the combined aqueous layers were back extracted with EtOAc (2 x 5 ml). Organic layers were dried (Na2S04), filtered and evaporated.The brown oil obtained was purified by column chromatography (SNAP KP-Sil 50g; eluted with Cy/EtOAc 3CV from 100% Cy to 90/10, 5CV 90/10).Evaporated fractions gave the title compound D44 as yellow oil (128 mg).UPLC (IPQC): rt = 1.43 minutes, peak observed: 381 (M+l) C20H23F3N2O2 requires: 380.1H NMR (400 MHz, CHLOROFORM-^ delta ppm 0.03 (br. s., 1 H) 0.75 (td, 1 H) 0.97 - 1.20 (m, 2 H) 1.42 - 1.54 (m, 9 H) 1.93 (br. s., 1 H) 2.27 (br. s., 1 H) 2.60 - 2.71 (m, 3 H) 3.74(br. s., 1 H) 4.01 (d, 1 H) 4.94-5.32 (br. s., 1 H) 7.30 - 7.34 (m, 1 H) 7.47 (s, 1 H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With potassium carbonate;bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; water; at 120℃; for 0.166667h;Microwave irradiation; | Example 118A 6-methyl-4,6'-bis(trifluoromethyl)-2,3'-bipyridine A 20 mL microwave vial was charged with 6-(trifluoromethyl)pyridin-3-ylboronic acid (644 mg, 3.37 mmol), <strong>[22123-14-4]2-chloro-6-methyl-4-(trifluoromethyl)pyridine</strong> (600 mg, 3.07 mmol), bis(triphenylphosphine)palladium(II) chloride (108 mg, 0.153 mmol), and K2CO3 (848 mg, 6.14 mmol), followed by the addition of DME (9.0 mL), water (3.86 mL) and ethanol (2.57 mL). The mixture was heated in the microwave at 120 C. for 10 minutes. The combined reaction mixtures were added 200 mL EtOAc, and filtered through a celite pad. The filtrate was washed with 200 mL water and 200 mL brine. The organic phase was dried over Na2SO4, filtered, and concentrated. The residue was chromatographed on a Grace Reveleris 80 g column, eluted with 0-40% EtOAc in Hexanes (35 mL/min) to provide the title compound (2.858 g, 9.33 mmol, 101% yield) as a yellow solid. MS (ESI+) m/z 307.1 (M+H); 1H NMR (300 MHz, DMSO-d6) delta 9.51 (d, J=2.1, 1H), 8.82 (ddd, J=8.4, 2.2, 0.5, 1H), 8.36 (s, 1H), 8.06 (dd, J=8.4, 0.5, 1H), 7.78 (s, 1H), 2.70 (s, 3H). |
Tags: 22123-14-4 synthesis path| 22123-14-4 SDS| 22123-14-4 COA| 22123-14-4 purity| 22123-14-4 application| 22123-14-4 NMR| 22123-14-4 COA| 22123-14-4 structure
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P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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