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Chemical Structure| 2212-06-8 Chemical Structure| 2212-06-8

Structure of 2212-06-8

Chemical Structure| 2212-06-8

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Product Details of [ 2212-06-8 ]

CAS No. :2212-06-8
Formula : C9H9BrO2
M.W : 229.07
SMILES Code : BrC1=CC=C(OCC2OC2)C=C1
MDL No. :MFCD00022341
InChI Key :YKUYKENINQNULY-UHFFFAOYSA-N
Pubchem ID :102766

Safety of [ 2212-06-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H319-H372-H410
Precautionary Statements:P260-P264-P273-P301+P312-P305+P351+P338-P314
Class:9
UN#:3077
Packing Group:

Application In Synthesis of [ 2212-06-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2212-06-8 ]

[ 2212-06-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 109-11-5 ]
  • [ 2212-06-8 ]
  • 4-[3-(4-bromophenoxy)-2-hydroxypropyl]morpholin-3-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
31% To a suspension of NaH, 60% dispersion in mineral oil, (148 mg, 3.71 mmol) in anhydrous DMF (2 mL), under N2 at 0C, was added <strong>[109-11-5]morpholin-3-one</strong> (250 mg, 2.47 mmol) in anhydrous DMF (3 mL) and the mixture stirred for 1 h at this temperature. After this time, the reaction mixture was allowed to warm to RT and 2-[(4-bromophenoxy)methyl]oxirane (850 mg, 3.71 mmol) in anhydrous DMF (5 mL) and the reaction stirred at RT, under N2, overnight. The reaction mixture was added dropwise to ice-water (50 mL) and extracted with EtOAc (50 mL). The organic phase was separated (phase seperator) and concentrated in vacuo. The crude compound was purified by silica gel column chromatography eluting with 0-3% MeOH/DCM. The compound was further purified by reversed phase preparative HPLC-MS to afford 4-[3-(4-Bromo-phenoxy)-2-hydroxy-propyl]-<strong>[109-11-5]morpholin-3-one</strong> as a white solid (250 mg, 31 %); LC-MS. Rt 1 .72 min, AnalpH2_MeOH_4min(1); (ESI+) m/z 330.1 , 332.1 [M+H]+.
 

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Related Parent Nucleus of
[ 2212-06-8 ]

Epoxides

Chemical Structure| 1024843-97-7

A802810 [1024843-97-7]

(S)-2-((3-Bromophenoxy)methyl)oxirane

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