Name: 21900-37-8|2,6-Dimethylbenzoyl chloride|95%
Brand: Ambeed
SKU: A362593
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1
[ 632-46-2 ]
[ 21900-37-8 ]

Yield	Reaction Conditions	Operation in experiment
86%	With thionyl chloride
	With thionyl chloride
	With phosphorus pentachloride

	With thionyl chloride Heating;
	With thionyl chloride
	With thionyl chloride In chloroform Heating;
	With thionyl chloride In N,N-dimethyl-formamide for 4h; Ambient temperature;
	With thionyl chloride; N,N-dimethyl-formamide for 5h;
	With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide for 2h; Heating;
	With thionyl chloride; triethylamine In tetrahydrofuran at 20℃; for 0.333333h;
	With thionyl chloride
	With oxalyl dichloride In dichloromethane
	With oxalyl dichloride In dichloromethane at 20℃; for 2h;	75.A Step A:; To a solution of 2,6-dimethylbenzoic acid (192 mg, 1.28 mmol) in dichloromethane (8 mL) was added oxalyl chloride (0.33 mL, 3.85 mmol) slowly. The reaction was stirred at room temperature for 2 h. The solvent was evaporated and the solid was directly redissolved in dichloromethane (8 mL). 2-amino-3-hydroxybenzoic acid hydrobromide (314 mg, 1.34 mmol) was added, followed by triethylamine (0.75 mL, 5.4 mmol). The resulting reaction mixture was stirred at room temperature overnight. The reaction was quenched with aqueous 2 N HCl (25 mL) until the solution reached pH 1. The aqueous layer was extracted with dichloromethane. The organic layers were washed with brine and dried over Na2SO4, filtered and concentrated. The residue was directly re-dissolved in toluene (7 mL) and the solution was treated with p-toluenesulfonic acid monohydrate (312 mg, 1.64 mmol). The reaction mixture was then heated to reflux for 1.5 h. The reaction was cooled down to room temperature and the toluene was evaporated. The reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was separated, then washed with water, brine, dried over Na2SO4, filtered and concentrated to a yellow solid. The crude product was purified by column chromatography (silica gel, 9:1 to 2:1 ethyl acetate/methanol) to afford the desired product (101 mg, 35%) as a yellow solid: 1H NMR (500 MHz, CD3OD) δ 7.95-7.86 (m, 1H), 7.79 (d, J=8.0 Hz, 1H), 7.48 (t, J=7.5 Hz, 1H), 7.30-7.24 (m, 1H), 7.14-6.98 (m, 2H), 3.34 (s, 3H), 3.31 (s, 3H); MS (ESI+) m/z 268 (M+H).
	With oxalyl dichloride In N,N-dimethyl-formamide; benzene
	With thionyl chloride In toluene for 2h; Heating / reflux;	5.a To a mixture of 2,6-dimethylbenzoic acid (3 g; 0.02 mol) in toluene (50 ml) was added thionyl chloride (3.6 ml; 0.05 mol). The mixture thus obtained was refluxed for 2 hours. The solvent and the excess thionyl chloride were then evaporated off under reduced pressure. The residue thus obtained was taken up in toluene (50 ml) three times and evaporated under reduced pressure. The product thus obtained (3.6 g) was used without further purification.
	With thionyl chloride In dichloromethane at 20℃; for 1h; Heating / reflux;	A.29.a 2,6-Dimethylbenzoic acid (0.0666 mol) was dissolved in dry CH2Cl2 (150 ml). A drop of DMF was added. Thionyl chloride (0.33 mol) was added in drops under nitrogen atmosphere at room temperature. The reaction mixture was stirred and refluxed for one hour. The solvent was evaporated under reduced pressure. The residue was dried (under oil pump vacuum), to give the intermediate acid chloride, which was dissolved in dry CH2Cl2 (30 ml), to give solution (I). Solution (I) was added to a solution of 1,4-dioxa- 8-azaspiro[4.5]decane-8-ethanamine (0.0733 mol) and Et3N (0.0666 mol) in dry CH2Cl2 (150 ml). The reaction mixture was stirred and refluxed for 90 minutes. The reaction mixture was cooled, washed with a saturated aqueous NaHCO3 solution (30 ml), washed with water (30 ml), dried (Na2SO4), filtered and the solvent was evaporated under reduced pressure, yielding 23 g of intermediate (81).
	With oxalyl dichloride In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere;	1.A EXAMPLE 1: Synthesis of Compound DP; 4-(3-(2,6-Dimethylbenzoyloxy) phenyl)-4-oxobutanoic acid; Step A: Preparation of 2,6-Dimethylbenzoyl chloride:; 2,6-Dimethylbenzoic acid (15 g, 99.88 mmol) was added to anhydrous CH2Cl2 (20 ml) at O0C followed by drop wise addition of oxalyl chloride (2M in CH2Cl2, 14.14 g) under argon. The reaction mixture was stirred at the same temperature for 30 minutes and then warmed to the room temperature for 1 hour, concentrated and used without purification.
	With thionyl chloride at 70 - 80℃; for 1h;
	With thionyl chloride; N,N-dimethyl-formamide at 50℃; for 2h;
	With oxalyl dichloride In dichloromethane for 2h;	1.G Step G. Preparation of (R)-tert-butyl l-((2,6- dimethylbenzamido)(phenyl)methyl)-7-azabicyclo [2.2.1] heptane- 7-carboxylate from (R)-tert-butyl l-(amino(phenyl)methyl)-7-azabicyclo[2.2.1]heptane-7-carboxylateTo a solution of 2,6-dimethylbenzoic acid (0.114 g, 0.76 mmol) in dichloromethane (2 niL) was added oxalyl chloride (0.133 mL, 1.52 mmol) followed by 1 drop of DMF. After 2 h, the solution was concentrated to an oily semi-solid, redissolved in dichloromethane and reconcentrated to a light gold oil. This oil was then added via syringe as a solution in dichloromethane (1 mL) to a solution of (R)-tert-butyl l-(amino(phenyl)methyl)-7- azabicyclo[2.2.1]heptane-7-carboxylate (0.046 g, 0.15 mmol) and DIPEA (0.213 mL, 1.22 mmol) also in dichloromethane (1.18 mL). After 4.5 h, the reaction was concentrated to minimal volume and stored in a freezer for 16 h. The reaction was then purified by flash column chromatography (SiC^, 0-100% ethyl acetate in hexanes) to afford (R)-tert-butyl 1-((2,6-dimethylbenzamido)(phenyl)methyl)-7-azabicyclo[2.2.1 ]heptane-7-carboxylate (0.052 g, 79 %) as a clear colorless residue. IH NMR (300 MHz, chloroform-J) δ ppm 1.24 - 1.36 (m, 2 H), 1.43 (s, 9 H), 1.47 - 1.56 (m, 1 H), 1.59 - 1.73 (m, 2 H), 1.73 - 1.89 (m, 2 H), 2.14 (td, /=8.2, 3.8 Hz, 1 H), 2.21 (s, 6 H), 4.30 (t, /=4.8 Hz, 1 H), 5.86 (d, /=8.6 Hz, 1 H), 6.96 (d, /=7.6 Hz, 2 H), 7.04 - 7.15 (m, 1 H), 7.20 - 7.35 (m, 3 H), 7.54 (dd, /=8.1, 1.4 Hz, 2 H), 8.15 (d, /=8.0 Hz, 1 H). m/z (ES+), (M+H)+ = 435.3.
	With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0℃; for 3h;	1 EXAMPLE 1; Methyl 2,6-dimethyl-benzoate; To a cooled (0° C.) solution of 2,6-dimethylbenzoic acid (20.2 g, 134 mmol) in dichloromethane (200 mL) is added DMF (1 mL) followed by oxalyl chloride (14 mL, 162 mmol). On completion of addition, the cold bath is removed and stirring continued for 3 h. The resulting solution is concentrated under vacuum and the residue added slowly to a cooled (0° C.) solution comprising methanol (200 mL) and triethylamine (40 mL). On completion of addition, the reaction mixture is stirred for 30 min. then poured into hydrochloric acid solution (400 mL, 2N) which is then extracted with ether. The ether extract is washed with hydrochloric acid solution (1N), sodium bicarbonate solution and brine then dried over MgSO4 and concentrated to give the title compound which is used without further purification. MS (EI) 164 (M)+.
	With thionyl chloride In N,N-dimethyl-formamide for 2h; Reflux;
	With thionyl chloride In toluene for 2h; Heating / reflux;	5.a Example 5 ; EPO Preparation of Compound 5 (RI=CH3CH2, R2=R6=CH3, R3=R4=R5=X=Y=H); a) 2.6-Dimethylbenzoyl chloride; To a mixture of 2,6-dimethylbenzoic acid (3 g; 0.02 mol) in toluene (50 ml) was added thionyl chloride (3.6 ml; 0.05 mol). The mixture thus obtained was refluxed for 2 hours. The solvent and the excess thionyl chloride were then evaporated off under reduced pressure. The residue thus obtained was taken up in toluene (50 ml) three times and evaporated under reduced pressure. The product thus obtained (3.6 g) was used without further purification.
	With thionyl chloride for 2h;	166.A Step A: Preparation of 2,6-dimethylbenzoyl chloride. DMF (2 drops) was added to 2,6-dimethylbenzoic acid (0.100 g, 0.666 mmol) in thionyl chloride (0.50 mL, 6.9 mmol). The reaction mixture was stirred for 2 h and concentrated to yield the titled compound, which was used in the next step without further purification.
	With thionyl chloride In pyridine at 20℃; for 2.5h; Inert atmosphere;
	With thionyl chloride In N,N-dimethyl-formamide for 2h; Reflux;	Typical Procedure for Amidation of 2,6-Disubstituted Benzoic Acids Through Acid Chloride Formation Typical Procedure for Amidation of 2,6-Disubstituted Benzoic Acids Through Acid Chloride Formation (Synthesis of N-[2-(3-chloro-benzylsulfanyl)-ethyl]-2,6-dimethyl-benzamide, 75 as representative example). One drop of DMF was added to a solution of 2,6-dimethylbenzoic acid (0.3 g, 2 mmol) in thionyl chloride (2 mL), and the mixture was refluxed for 2 h. It was then cooled to room temperature and the excess thionyl chloride was removed in vacuo. The solid residue was dissolved in dry DCM (5 mL) and cooled to 0° C. A mixture of β-(3-chlorobenzyl)mercaptoethylamine (0.404 g, 2 mmol) and triethylamine (1 mL, 7 mmol) in dry DCM (5 mL) was added in dropwise manner at 0° C. under nitrogen atmosphere, and the mixture was allowed to stir at room temperature for 1.5 h. After the completion of reaction (as judged by TLC) the solvent was removed in vacuo and the solid residue was dissolved in DCM (30 mL). The organic phase was washed with brine (15 mL) and water (15 mL), dried over Na2SO4, and concentrated in vacuo. The crude residue was purified by silica gel column chromatography using a mixture of hexane/ethyl acetate (gradient from 15% v/v ethyl acetate/hexane to 35% v/v ethyl acetate/hexane) as eluent to obtain the desired amidated product, 75 (0.507 g, 76%): mp=53-55° C. 1H NMR (CDCl3, 400 MHz): δ 2.27 (s, 6H), 2.65 (t, J=6.4 Hz, 2H), 3.57 (q, J=6.4 Hz, 2H), 3.69 (s, 2H), 6.06 (bs, 1H), 6.99 (d, J=7.6 Hz, 2H), 7.14 (t, J=7.6 Hz, 1H), 7.19-7.23 (m, 3H), 7.32 (s, 1H). 13C NMR (CDCl3, 100 MHz): δ 19.41, 31.42, 35.46, 38.11, 127.27, 127.65, 127.71, 128.96, 129.12, 130.07, 134.39, 134.65, 137.61, 140.32, 170.61. HRMS calculated for C18H21ClNOS (M+H)+ 334.10324, found 334.10221.
	With thionyl chloride In toluene Reflux;	2.1 Step 1) 2,6-dimethyl-N-phenylbenzamide To a suspension of 2,6-dimethyl benzoic acid (5.0 g, 33.29 mmol) in toluene (100 was added SOCl12 (12.08 mL, 166.47 mmol) at rt. The reaction was stirred at reflux overnight, then cooled to rt and concentrated in vacuo. The residue was dissolved in DCM (50 mL), and the solution was used for the next step directly.
	With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃;	1.5 Oxalyl chloride (0.105 mL, 1.199 mmol) was added dropwise to a solution of 2,6-dimethylbenzoic acid (150 mg, 0.999 mmol) in DCM (6 mL) and the reaction was stirred at room temperature overnight. Solvents were evaporated giving 140 mg (83%) of crude acid chloride as a white solid (Intermediate 5a) and was used directly in the next step in the preparation of Example 2.
	With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 4h; Inert atmosphere;	20.1 Step 1) 2,6-dimethyl-N-phenylbenzamide [379] To a mixture of 2,6-dimethylbenzoic acid (1.99 g, 13.3 mmol) and N,N- dimethylformamide (103 mg, 1.409 mmol) in dichloromethane (15 mL) was added oxalyl di chloride (2.25 mL) at rt. The reaction was stirred at rt for 4 hours, then concentrated in vacuo, and the residue was dissolved in 4 mL of 1,4-dioxane. The resulted solution was added to a mixture of aniline (1.28 g, 13.7 mmol) and sodium bicarbonate (2.80 g, 175 mmol) in 1,4- dioxane (11 mL) and water (7 mL) at 0 °C, then moved to rt, and stirred overnight. The mixture was poured into 0 (100 mL), and extracted with EtOAc (50 mL χ 2). The combined organic phase was concentrated in vacuo, and the residue was purified by a silica gel column chromatography (PE EtOAc (v/v) = 10/1) to give the title compound as an off-white solid (740 mg, 25%). MS (ESI, pos. ion) m/z: 226.0 [M+H]+; NMR (400 MHz, CDCb) δ (ppm): 7.63-7.61 (d, J = 8.0 Hz, 2H), 7.39-7.36 (dd, J = 8.0, 8.0 Hz, 2H), 7.36 (br s, 1 H), 7.23-7.13 (m, 2H), 7.08-7.06 (d, J= 7.6 Hz, 2H), 2.40 (s, 6H).
	Stage #1: 2,6-dimethylbenzoic acid With N,N-dimethyl-formamide In dichloromethane at 0℃; for 0.0833333h; Stage #2: With thionyl chloride In dichloromethane at 0 - 20℃;	Synthesis of 2,6-dimethylbenzoyl chloride To a stirred CH2Cl2 (12 mL) solution of 2,6-dimethylbenzoic acid 0.3 g (2 mmol) was added DMF (0.016 mL) at 0 °C, and the resulting solution was stirred for 5 min. To the solution was added SOCl2 (0.4 mL) at 0 °C and the resulting solution was stirred at room temperature for 12 h, and concentrated in vacuo to give 2,6-dimethylbenzoyl chloride, which was used for the synthesis of 1-pyrenyl 2,6-dimethylbenzoate (1h) without purification.
	With thionyl chloride at 60℃; for 2h;	1.3 Experimental Procedure: A mixture of 2,4,6-Trimethyl benzoic acid (50 g, 0.333 mol) and thionyl chloride (100 mL) was heated at 60° C. for 2 h. In-process check for acid chloride formation was confirmed by quenching an aliquot with methanol. (0174) After complete conversion, excess thionyl chloride was removed under vacuum.
	With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0℃; for 1.5h; Inert atmosphere;
	With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 2h;
	With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 3.16667h; Inert atmosphere;
	With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 2h; Sealed tube; Inert atmosphere;
	With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 2h;	12 To a stirred solution of 2,6-dimethylbenzoic acid (3 g, 20 mmol, 1.0 eq.) in anhydrous DCM (60 mL) was added DMF (10 drops, cat.) followed by dropwise addition of oxalyl chloride (3.43 mL, 40 mmol, 2.0 eq.) at 0° C. The solution was gradually brought to r.t. and stirred for 2 h. After such time, the volatiles were removed by concentration of the crude reaction mixture and the crude acid chloride was used directly in the following step without purification.
	With thionyl chloride at 70℃; for 1h;
	With thionyl chloride In toluene at 100℃; for 0.5h;	2-(2,6-Dimethylphenyl)-6-nitro-1,3-benzoxazole (5) To a solution of 2,6-dimethylbenzoic acid (3) (0.55g, 3.7 mmol) in toluene (4 mL) was added thionyl chloride (0.53 mL, 7.3 mmol). The mixture was stirredat 100 C for 30 min. After cooling to rt, the solvent was then distilled under reduced pressure to givecrude 2,6-dimethylbenzoyl chloride (0.62 g), which was used in the next reaction without furtherpurification

Reference： [1]Bowman, W. Russell; Forshaw, J. Anthony; Hall, Kevin P.; Kitchin, Jonathan P.; Mott, Andrew W. [Tetrahedron, 1996, vol. 52, # 11, p. 3961 - 3972]
[2]Fuson et al. [Journal of the American Chemical Society, 1940, vol. 62, p. 2091,2092] Coops et al. [Recueil des Travaux Chimiques des Pays-Bas, 1940, vol. 59, p. 1109,1111] de Jong [Recueil des Travaux Chimiques des Pays-Bas, 1942, vol. 61, p. 539,544] Yates, Keith; Mandrapilias, George [Journal of Organic Chemistry, 1980, vol. 45, # 19, p. 3892 - 3902] Bentkey, T. William; Harris, H. Carl; Koo, In Sun [Journal of the Chemical Society. Perkin transactions II, 1988, p. 783 - 790]
[3]Coops et al. [Recueil des Travaux Chimiques des Pays-Bas, 1940, vol. 59, p. 1109,1111] Lock; Schmidt [Journal fur praktische Chemie (Leipzig 1954), 1934, vol. <2> 140, p. 229,231]
[4]THOMAS; STOKER [Journal of Pharmacy and Pharmacology, 1961, vol. 13, p. 129 - 138]
[5]Haering,M. [Helvetica Chimica Acta, 1960, vol. 43, p. 104 - 113]
[6]Duncia, John V.; Pierce, Michael E.; Santella, Joseph B. [Journal of Organic Chemistry, 1991, vol. 56, # 7, p. 2395 - 2400]
[7]Collman, James P.; Brauman, John I.; Fitzgerald, Jeffrey P.; Hampton, Philip D.; Naruta, Yoshinori; et al. [Journal of the American Chemical Society, 1988, vol. 110, # 11, p. 3477 - 3486]
[8]Michida; Kyuhara; Nishiyama; Yoshimi; Fitzgerald; Sayo [Chemical and Pharmaceutical Bulletin, 1992, vol. 40, # 12, p. 3157 - 3162]
[9]Keck, Gary E; McLaws, Mark D; Wager, Travis T [Tetrahedron, 2000, vol. 56, # 51, p. 9875 - 9883]
[10]Lehmann, Fredrik; Currier, Erika A.; Olsson, Roger; Hacksell, Uli; Luthman, Kristina [Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 8, p. 3057 - 3068]
[11]Liu, Kwang-Ting; Chen, Hung-I [Journal of the Chemical Society. Perkin Transactions 2 (2001), 2000, # 4, p. 893 - 898]
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[13]Current Patent Assignee: CURIA INC - US2006/183769, 2006, A1 Location in patent: Page/Page column 35
[14]Beaume, Aurore; Courillon, Christine; Derat, Etienne; Malacria, Max [Chemistry - A European Journal, 2008, vol. 14, # 4, p. 1238 - 1252]
[15]Current Patent Assignee: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO - A.C.R.A.F. - S.P.A. ENUNCIABILE ANCHE A.C.R.A.F. S.P.A. , ACRAF S.P.A. , ANGELINI S.P.A. - US2008/207727, 2008, A1 Location in patent: Page/Page column 5-6
[16]Current Patent Assignee: JOHNSON & JOHNSON INC - WO2009/62990, 2009, A2 Location in patent: Page/Page column 42-43
[17]Current Patent Assignee: WELLSTAT GROUP OF COMPANIES - WO2009/91732, 2009, A1 Location in patent: Page/Page column 26
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[21]Current Patent Assignee: SANOFI - US7005440, 2006, B1 Location in patent: Page/Page column 150
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2
[ 21900-37-8 ]
[ 55321-98-7 ]

Yield	Reaction Conditions	Operation in experiment
	With ammonia; benzene
	Multi-step reaction with 2 steps 1: 98 percent / H₂SO₄ / toluene / 4 h / Heating 2: 99 percent / Na₂CO₃, H₂O / 4 h / Heating
	With ammonium hydroxide In dichloromethane at 0 - 20℃; for 1h;

Reference： [1]Lock; Schmidt [Journal fur praktische Chemie (Leipzig 1954), 1934, vol. <2> 140, p. 229,231]
[2]Adolphe-Pierre; Menager; Tombret; Verite; Lepage; Lafont [Il Farmaco, 1998, vol. 53, # 7, p. 513 - 518]
[3]Hoque, Md Emdadul; Bisht, Ranjana; Unnikrishnan, Anju; Dey, Sayan; Mahamudul Hassan, Mirja Md; Guria, Saikat; Rai, Rama Nand; Sunoj, Raghavan B.; Chattopadhyay, Buddhadeb [Angewandte Chemie - International Edition, 2022, vol. 61, # 27][Angew. Chem., 2022, vol. 134, # 27]

3
[ 67-56-1 ]
[ 21900-37-8 ]
[ 14920-81-1 ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; at 0℃; for 0.5h;	EXAMPLE 1; Methyl 2,6-dimethyl-benzoate; To a cooled (0 C.) solution of 2,6-dimethylbenzoic acid (20.2 g, 134 mmol) in dichloromethane (200 mL) is added DMF (1 mL) followed by oxalyl chloride (14 mL, 162 mmol). On completion of addition, the cold bath is removed and stirring continued for 3 h. The resulting solution is concentrated under vacuum and the residue added slowly to a cooled (0 C.) solution comprising methanol (200 mL) and triethylamine (40 mL). On completion of addition, the reaction mixture is stirred for 30 min. then poured into hydrochloric acid solution (400 mL, 2N) which is then extracted with ether. The ether extract is washed with hydrochloric acid solution (1N), sodium bicarbonate solution and brine then dried over MgSO4 and concentrated to give the title compound which is used without further purification. MS (EI) 164 (M)+.

Reference： [1]Chemische Berichte,1975,vol. 108,p. 1694 - 1711
[2]Patent: US7005440,2006,B1 .Location in patent: Page/Page column 150

4
[ 64-17-5 ]
[ 21900-37-8 ]
[ 632-46-2 ]
[ 36596-67-5 ]

Yield	Reaction Conditions	Operation in experiment
	With water at 10℃; solvolysis examined; var. solvents and ratio of ones; mechanism; ΔH(excit.), ΔS(excit.);

Reference： [1]Bentkey, T. William; Harris, H. Carl; Koo, In Sun [Journal of the Chemical Society. Perkin transactions II, 1988, p. 783 - 790]

5
[ 64-17-5 ]
[ 21900-37-8 ]
[ 36596-67-5 ]

Yield	Reaction Conditions	Operation in experiment
8.7 g	With triethylamine In dichloromethane for 1h;

Reference： [1]Collman, James P.; Brauman, John I.; Fitzgerald, Jeffrey P.; Hampton, Philip D.; Naruta, Yoshinori; et al. [Journal of the American Chemical Society, 1988, vol. 110, # 11, p. 3477 - 3486]

6
[ 917-54-4 ]
[ 21900-37-8 ]
[ 2142-76-9 ]

Reference： [1]Journal of Organic Chemistry,1980,vol. 45,p. 3892 - 3902

7
[ 2386-52-9 ]
[ 21900-37-8 ]
[ 85374-78-3 ]

Reference： [1]Chemische Berichte,1983,vol. 116,p. 1183 - 1194

8
[ 21900-37-8 ]
[ 62285-58-9 ]

Reference： [1]Helvetica Chimica Acta,1960,vol. 43,p. 104 - 113

9
[ 21900-37-8 ]
[ 35100-92-6 ]
[ 165333-66-4 ]
3-amino-5-methyl-N₁-(2,6-dimethylbenzoyl)pyrazole [ No CAS ]
5-amino-3-methyl-N₁-(2,6-dimethylbenzoyl)pyrazole [ No CAS ]

Reference： [1]European Journal of Medicinal Chemistry,1995,vol. 30,p. 147 - 155

10
[ 21900-37-8 ]
[ 35100-92-6 ]
[ 139297-17-9 ]

Yield	Reaction Conditions	Operation in experiment
38%	With sodium hydrogencarbonate; In dichloromethane; ethyl acetate;	EXAMPLE 9 Preparation of N-(1,5-dimethylpyrazol-3-yl)-2,6 dimethyl benzamide (compound 3) To a cooled (0-5 C.) solution of 3-amino-1,5-dimethyl pyrazole (95%, 32.7 g, 0.28M) in anhydrous CH2 Cl2 (200 ml) was added a CH2 Cl2 (100 ml) solution of the 2,6 dimethyl benzoyl chloride (23.6 g, 0.14M). The reaction mixture was allowed to room temperature for 18 hours and then CH2 Cl2 was concentrated to give an oily mixture which was diluted in AcOEt. This suspension was then treated with saturated NaHCO3. After usual work-up, the crude material was cristallized with diisopropyloxide to give 13 g of the desired amide (38%: yield based on the 2,6-dimethyl benzoyl chloride). m.p.: 184 C.

Reference： [1]European Journal of Medicinal Chemistry,1995,vol. 30,p. 147 - 155
[2]Patent: US5464860,1995,A

11
[ 15118-60-2 ]
[ 21900-37-8 ]
4-[4-(2,6-Dimethyl-benzoylamino)-phenyl]-butyric acid [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1996,vol. 39,p. 2571 - 2578

12
[ 16947-63-0 ]
[ 21900-37-8 ]
N-(2,4-dimethyl-4-nitrophenyl)-2,6-dimethylbenzamide [ No CAS ]

Reference： [1]Organic and Biomolecular Chemistry,2007,vol. 5,p. 1062 - 1080

13
[ 5680-80-8 ]
[ 21900-37-8 ]
[ 905571-01-9 ]

Yield	Reaction Conditions	Operation in experiment
86%	With triethylamine In dichloromethane at 20℃; for 12h;
	With triethylamine In dichloromethane at 0 - 20℃;

Reference： [1]Nanchen, Steve; Pfaltz, Andreas [Chemistry - A European Journal, 2006, vol. 12, # 17, p. 4550 - 4558]
[2]Location in patent: experimental part Dieguez, Montserrat; Pamies, Oscar [Chemistry - A European Journal, 2008, vol. 14, # 12, p. 3653 - 3669]

14
[ 6575-13-9 ]
[ 21900-37-8 ]

Reference： [1]Helvetica Chimica Acta,1960,vol. 43,p. 104 - 113

15
[ 21900-37-8 ]
[ 305794-44-9 ]
[ 305794-30-3 ]

Yield	Reaction Conditions	Operation in experiment
97%	With sodium hydroxide In dichloromethane; water at 20℃;	1 A solution of free amine 29 (1.45 g, 3.97 mmol) and 2,6-dimethylbenzoyl chloride (840 mg, 5.0 mmol) in aqueous 1 N NaOH (20 ml) and CH2Cl2 (20 ml) was stirred overnight at RT. The reaction mixture was extracted with CH2Cl2, dried over Na2SO4 and concentrated under high vacuum to provide 30 (1.97 g, 97%), as a slightly yellow foam. To a solution of ketone 30 (550 mg, 1.11 mmol) in CH3OH (6 ml) was added NaBH4 (60 mg, 1.59 mmol) and the solution was stirred overnight at RT. The reaction mixture was then poured into 0.1 N NaOH, extracted with CH2Cl2, dried over Na2SO4, and concentrated to give 31 (543 mg, 98%), as a slightly yellow foam.

Reference： [1]Current Patent Assignee: MERCK & CO INC - EP1175402, 2005, B1 Location in patent: Page/Page column 17

16
1-(2-fluorophenyl)-2-methyl-1,2-propanediamine dihydrochloride [ No CAS ]
[ 21900-37-8 ]
N-[2-amino-1-(2-fluorophenyl)-2-methylpropyl]-2,6-dimethylbenzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
61%	With triethylamine In dichloromethane at 20℃;	24 A solution of 1-(2-fluorophenyl)-2-methyl-1 ,2-propanediamine dihydrochloride (D10) (207mg, 0.81 mmol), triethylamine (56OuI, 4.0mmol) and 2,6-dimethylbenzoyl chloride (136mg, 0.81 mmol) in dry DCM (10ml) was stirred at room temperature overnight. The reaction mixture was washed with saturated sodium hydrogen carbonate solution, dried and evaporated to give crude product which was chromatographed on silica gel. Elution with 20-100% ethyl acetate in pentane gave Λ/-[2-amino-1-(2-fluorophenyl)-2- methylpropyl]-2,6-dimethylbenzamide as a white solid (155mg, 61%). δH (400 MHz, CDCI3) 1.10 (3H, s), 1.32 (3H, s), 2.24 (6H, s), 5.34 (1 H, d, J = 8.8 Hz), 7.00 (2H, m), 7.1 - 7.4 (8H, overlapping m) ppm. LC/MS: m/z (ES+) 315 (MH+, C19H23N2OF requires 314), Retention time 1.64 minutes.

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2006/67414, 2006, A2 Location in patent: Page/Page column 59

17
[ 906096-11-5 ]
[ 21900-37-8 ]
C₁₆H₁₅NO₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine In dichloromethane at 20℃;	75.A Step A:; To a solution of 2,6-dimethylbenzoic acid (192 mg, 1.28 mmol) in dichloromethane (8 mL) was added oxalyl chloride (0.33 mL, 3.85 mmol) slowly. The reaction was stirred at room temperature for 2 h. The solvent was evaporated and the solid was directly redissolved in dichloromethane (8 mL). 2-amino-3-hydroxybenzoic acid hydrobromide (314 mg, 1.34 mmol) was added, followed by triethylamine (0.75 mL, 5.4 mmol). The resulting reaction mixture was stirred at room temperature overnight. The reaction was quenched with aqueous 2 N HCl (25 mL) until the solution reached pH 1. The aqueous layer was extracted with dichloromethane. The organic layers were washed with brine and dried over Na2SO4, filtered and concentrated. The residue was directly re-dissolved in toluene (7 mL) and the solution was treated with p-toluenesulfonic acid monohydrate (312 mg, 1.64 mmol). The reaction mixture was then heated to reflux for 1.5 h. The reaction was cooled down to room temperature and the toluene was evaporated. The reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was separated, then washed with water, brine, dried over Na2SO4, filtered and concentrated to a yellow solid. The crude product was purified by column chromatography (silica gel, 9:1 to 2:1 ethyl acetate/methanol) to afford the desired product (101 mg, 35%) as a yellow solid: 1H NMR (500 MHz, CD3OD) δ 7.95-7.86 (m, 1H), 7.79 (d, J=8.0 Hz, 1H), 7.48 (t, J=7.5 Hz, 1H), 7.30-7.24 (m, 1H), 7.14-6.98 (m, 2H), 3.34 (s, 3H), 3.31 (s, 3H); MS (ESI+) m/z 268 (M+H).

Reference： [1]Current Patent Assignee: CURIA INC - US2006/183769, 2006, A1 Location in patent: Page/Page column 35

18
[ 910905-86-1 ]
[ 21900-37-8 ]
2,6-dimethyl-N-{2-[4-(2-pyrrolidin-1-yl-ethylcarbamoyl)phenylamino]-pyrimidin-5-yl}-benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
12%	With N-ethyl-N,N-diisopropylamine In tetrahydrofuran Heating / reflux;	77 Example 77. 2,6-DimethvI-JV-{2-r4-(2-pyrrolidin-l-yl-ethylcarbamoylV phenylaminoi-pyrimidin-5-yU-benzamide (XXIX); [0235] To the amine 45 described in Example 68 (35 mg, 0.1 mmol) in 10 mL THF was added 2,6-dimethylbenzoyl chloride (21 mg, 0.12 mmol) and diisopropyl ethyl amine (52 μL, 0.3 mmol). The reaction mixture was refluxed overnight. The solvent evaporated and the residue was dissolved in DMSO, and separated using prep HPLC to give a brown syrup (6 mg, 12 %).[0236] 1H NMR (MeOH-d4): δ 2.01-2.12 (m, 2H), 2.15-2.25 (m, 2H), 2.39 (s, 6H), 3.14-3.22 (m, 2H), 3.44 (t, J- 5.8 Hz, 2H), 3.75 (t, J= 5.8 Hz, 2H), 3.76-3.85 (m, 2H), 7.13 (d, J= 7.7 Hz, 2H), 7.25 (t, J = 7.6 Hz, IH), 7.87 (dd, J= 8.1 Hz, J= 6.6 Hz, 4H), 8.83 (s, 2H). MS (ES+): m/z = 460 (M+H)+.

Reference： [1]Current Patent Assignee: SANOFI - WO2006/101977, 2006, A2 Location in patent: Page/Page column 79

19
[ 910907-93-6 ]
[ 21900-37-8 ]
[ 910907-98-1 ]

Yield	Reaction Conditions	Operation in experiment
23%	With triethylamine In tetrahydrofuran for 19h; Heating / reflux;	122 Example 122. 4-{445-(2,6-Dimethyl-benzovIaminoVpyrimidin-2-ylammo]-benzoyli- piperazine-1-carboxylic acid fert-butvl ester (69); [0299] To a solution of compound 68 described in Example 121 (0.20 g, 0.50 mmol) and 2,6-dimethyl-benzoyl chloride (0.20 g, 1.2 mmol) in THF (15 mL) was added triethylarnine (0.20 mL, 1.4 mmol). The mixture was heated at reflux for 19 h. The EPO mixture was allowed to cool to room temperature and most of the THF removed. The resulting residue was redissolved in EtOAc, washed with saturated NaHCO3, brine, dried over MgS O4 and filtered. The filtrate was concentrated and the residue purified by flash chromatography on silica gel (5% MeOH/DCM) to afford the title compound as a pale yellow solid (60 mg, 23%).

Reference： [1]Current Patent Assignee: SANOFI - WO2006/101977, 2006, A2 Location in patent: Page/Page column 105-106

20
[ 910903-73-0 ]
[ 21900-37-8 ]
2,6-dimethyl-N-{2-[4-(2-pyrrolidin-1-yl-ethylsulfamoyl)-phenylamino]-pyrimidin-5-yl}-benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
15%	With N-ethyl-N,N-diisopropylamine In dichloromethane; toluene for 20h; Heating / reflux;	19 Example 19. 2,6-Dimethyl-iV-{2-f4-(2-pyrroIidin-l-vI-ethvIsulfamoyl)-phenvIamino1-PVrimidin-5-vU-benzamide (VI); [0150] Compound 8 described in Example 11 (0.05 g, 0.14 mmol, 1 equiv) was diluted with 4mL DCM and treated with DIEA (53 μL, 0.30 mmol, 2.2 equiv) and 2,6-dimethyl- benzoyl chloride (0.023 g, 0.14 mmol, 1 equiv). After 18 h, additional 1.0 equiv of 2,6- dimethyl-benzoyl chloride and 4 mL toluene were added. This was then heated to reflux for 2 hours. Reaction was then cooled to ambient temperature and evaporated to brown residue. HPLC purification provided the title compound as a white solid (0.01 g, 15%).1H NMR (DMSO-d6): δ 1.84-1.88 (m, 2H), 1.98-2.02 (m, 2H), 2.29 (s, 6H), 2.97-3.05 (m, 4H), 3.19-3.25 (m, 2H), 3.48 (bs, IH), 3.52-3.60 (m, 2H), 7.13 (d, J= 7.6 Hz, 2H), 7.26 (t, J= 7.6 Hz, IH), 7.73 (d, J= 9.0 Hz, 2H), 7.76 (t, J= 6.2 Hz5 IH), 7.97 (d, J= 8.9 Hz, 2H), 8.88 (s, 2H), 9.55 (bs, IH), 10.22 (s, IH) 10.55 (s, IH). MS (ES+): m/z = 496 (M+H)+. LC retention time: 2.06 min.

Reference： [1]Current Patent Assignee: SANOFI - WO2006/101977, 2006, A2 Location in patent: Page/Page column 46

21
[ 910904-67-5 ]
[ 21900-37-8 ]
N-(2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-5-yl)-2,6-dimethyl-benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
16%	Stage #1: N-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-pyrimidine-2,5-diamine; 2,6-dimethylbenzoyl chloride With triethylamine In toluene for 18h; Heating / reflux; Stage #2: With sodium hydrogencarbonate In dichloromethane; water; toluene	94 Example 94. iV-(2-(4-(2-(Pyrrolidin-l-yl)ethoxy)phenylamino)pyriiiiidin-5-yl)-2,6- dimethvl- benzamide (XXXIX); [0265] To a solution of compound 54 described in Example 92 (109 mg, 0.36 mmol) in anhydrous PhMe (6 mL) was added 2,6-dimethylbenzoyl chloride (74 mg, 0.44 mmol). The mixture was heated under reflux for 18 h. The saturated NaHCO3 (30 mL) and CH2Cl2 (30 ml) were added. Organic phase was separated and aqueous was extracted with CH2Cl2 (3 x 10 mL). The combined organic solution was dried (Na2SO4). The product was purified by preparative HPLC; fractions containing the products were combined. EtOAc (20 ml) and saturated NaHCO3 (20 mL) were added and organic phase was separated. The aqueous phase was extracted with EtOAc (2 x 10 mL). Combined organic solution was dried (Na2SO4) to yield the final product (33 mg, 16%) as a yellow solid.[0266] 1H NMR (DMSO-d6): δ 1.88-191 (m, 2H), 1.98-2.03 (in, 2H), 2.29 (s, 6H), 3.08-3.12 (m, 2H), 3.54-3.59 (m, 4H), 4.30 (t, J= 4.9 Hz, 2H), 6.96 (d, J= 7.0 Hz, 2H), 7.12 (d, J= 7.7 Hz, 2H), 7.24 (t, J= 7.6, IH), 7.66 (d, J= 7.0 Hz, 2H), 8.74 (s, 2H), 9.52 (s, IH), 10.40 (s, IH), 10.57 (br, IH). MS (ES+): m/z = 433 (M+H)+.

Reference： [1]Current Patent Assignee: SANOFI - WO2006/101977, 2006, A2 Location in patent: Page/Page column 90

22
[ 910903-47-8 ]
[ 21900-37-8 ]
N-{2-[3-(2-dimethylamino-ethylsulfamoyl)-phenylamino]-pyrimidin-5-yl}-2,6-dimethyl-benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
48%	With triethylamine In toluene at 111℃; for 18h;	4 Example 4. ./V-ll-P-CZ-DiinethvIamino-ethylsulfamovD-phenvIaiiiinol-pyriindin-S- vI}-2, 6-dimethyl-benzamide (T); [0132] Compound 2 (0.055 mmol, 2.0 equiv) described in Example 3, 2, 6- dimethylbenzoyl chloride (0.030 mmol, 1.0 equiv) and TEA (0.12 mmol, 4.0 equiv) were dissolved in 5 mL toluene. The reaction mixture was refluxed at 1110C for 18 h under an argon atmosphere. After cooling to room temperature, the reaction was dissolved in DCM and washed with saturated NaHCO3 and brine. The organic phase was dried (MgSO4) and concentrated under reduced pressure. Prep HPLC run using a 10-50-75 acetonitrile and water mobile phase to give the title compound as a white solid (6.7mg, 48%).[0133] Rt = 0.14 (DCM/MeOH 9:1). 1H NMR (DMSO-d6): δ 2.08 (bs, 3H), 2.29 (s, 6H), 2.88 (bs, 3H), 3.32 (smear under water, 6H), 7.13 (d, J= 7.7 Hz, IH), 7.24 (t, J= 7.6 Hz, 2H), 7.34 (d, J= 8.2 Hz, IH), 7.47 (t, J= 8.0 Hz, 2H), 7.66 (d, J= 8.6 Hz, 2H), 7.87 (t, J=8.5 Hz,2H), 8.36 (s, IH), 8.84 (s, 2H), 10.02 (s, IH), 10.51 (s, IH). MS (ES+): m/z = 469 (M+H)+. LC retention time: 2.02 min.

Reference： [1]Current Patent Assignee: SANOFI - WO2006/101977, 2006, A2 Location in patent: Page/Page column 38

23
[ 21900-37-8 ]
[ 56973-26-3 ]
5-carbamoyl-1H-imidazole-4-yl 2',6'-dimethylbenzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; In pyridine;	EXAMPLE 1 To a suspension of 0.636 g. of 4-carbamoylimidazolium-5-olate in 15 ml of dry pyridine was dropwise added 1.2 g of 2,6-dimethylbenzoyl chloride at a temperature below 5 C. in N2 atmosphere. After being stirred for two hours at 41-43 C., the reaction mixture was cooled to room temperature and 0.8 g of triethylamine was added, and separated crystals were filtered off. Then the filtrate was concentrated under reduced pressure, and separated crystals were filtered off, washed with toluene and ether and dried to give 0.689 g of 5-carbamoyl-1H-imidazole-4-yl 2',6'-dimethylbenzoate, m.p. 176-177 C. Crude material was recrystallized from N,N-dimethylformamide and water. m.p.: 180-180.5 C.

Reference： [1]Patent: US4410696,1983,A

24
[ 79-37-8 ]
methyl 2-amino-3-(4-((2,6-dichlorophenyl)carbonylamino)-2-oxohydropyrimidinyl)propionate ⁽²³²⁾ TFA salt [ No CAS ]
[ 1466-76-8 ]
[ 144-55-8 ]
[ 21900-37-8 ]
methyl (2S)-3-(4-((2,6-dichlorophenyl)carbonylamino)-2-oxohydropyrimidinyl)-2-((2,6-dimethoxyphenyl)carbonylamino)propionate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
86%	With triethylamine In dichloromethane	243 Methyl (2S)-3-(4-((2,6-dichlorophenyl)carbonylamino)-2-oxohydropyrimidinyl)-2-((2,6-dimethoxyphenyl)carbonylamino)propionate (243) Example 243 Methyl (2S)-3-(4-((2,6-dichlorophenyl)carbonylamino)-2-oxohydropyrimidinyl)-2-((2,6-dimethoxyphenyl)carbonylamino)propionate (243) To a solution of 100 mg (0.200 mmol) of methyl 2-amino-3-(4-((2,6-dichlorophenyl)carbonylamino)-2-oxohydropyrimidinyl)propionate (232) TFA salt in 3 ml of dichloromethane, were added 0.28 ml (0.400 mmol) of triethylamine and 3 ml of a solution of 2,6-dimethylbenzoyl chloride (prepared from 73 mg (0.40 mmol) of 2,6-dimethoxybenzoic acid and 0.042 ml of oxalyl chloride) in dichloromethane, and the mixture was stirred at room temperature for 3.5 hours. Saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, and the resulting mixture was extracted with chloroform. Organic layers were combined, washed with 1N hydrochloric acid and saturated brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by column chromatography (silica gel; chloroform/methanol = 60/1-40/1) to obtain 94 mg of methyl (2S)-3-(4-((2,6-dichlorophenyl)carbonylamino)-2-oxohydropyrimidinyl)-2-((2,6-dimethoxyphenyl)carbonylamino)propionate (243) (yield: 86%). LR-MS (m/z): 547 [(M-H)-] IR (KBr): 3248, 3075, 3012, 2954, 2840, 1739, 1715, 1661, 1595, 1564, 1494, 1433, 1370, 1340, 1304, 1253, 1195, 1112, 1032 cm-1 1H-NMR (300MHz, CDCI3, δppm): 3.83(6H, s), 3.86(3H, s), 4.45(1H, dd, J= 5.7, 13.5 Hz), 4.67(1H, d, 12.9 Hz), 4.92(1H, t, J= 5.1 Hz), 6.58(2H, d, J= 8.4 Hz), 7.29-7.41(6H, m), 7.57(1H, d, J= 7.5 Hz), 7.89(1H, d, J= 7.2 Hz) [α]D20= -34.1° (c = 0.044, CH3OH)

Reference： [1]Current Patent Assignee: TORAY INDUSTRIES INC - EP1209147, 2002, A1

25
[ 79-37-8 ]
methyl 2-amino-3-(4-((2,6-dichlorophenyl)carbonylamino)-2-oxohydropyrimidinyl)propionate ⁽²³²⁾ TFA salt [ No CAS ]
[ 1975-52-6 ]
[ 144-55-8 ]
[ 21900-37-8 ]
methyl (2S)-3-(4-((2,6-dichlorophenyl)carbonylamino)-2-oxohydropyrimidinyl)-2-((2-methyl-5-nitrophenyl)carbonylamino)propionate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
98%	With triethylamine In dichloromethane	245 Methyl (2S)-3-(4-((2,6-dichlorophenyl)carbonylamino)-2-oxohydropyrimidinyl)-2-((2-methyl-5-nitrophenyl)carbonylamino)propionate (245) Example 245 Methyl (2S)-3-(4-((2,6-dichlorophenyl)carbonylamino)-2-oxohydropyrimidinyl)-2-((2-methyl-5-nitrophenyl)carbonylamino)propionate (245) To a solution of 100 mg (0.200 mmol) of methyl 2-amino-3-(4-((2,6-dichlorophenyl)carbonylamino)-2-oxohydropyrimidinyl)propionate (232) TFA salt in 3 ml of dichloromethane, were added 0.28 ml (0.400 mmol) of triethylamine and 3 ml of a solution of 2,6-dimethylbenzoyl chloride (prepared from 72 mg (0.40 mmol) of 2-methyl-5-nitrobenzoic acid and 0.042 ml of oxalyl chloride) in dichloromethane, and the mixture was stirred at room temperature for 1.5 hours. Saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture, and the resulting mixture was extracted with chloroform. Organic layers were combined, washed with 1N hydrochloric acid and saturated brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by column chromatography (silica gel; chloroform/methanol = 60/1-40/1) to obtain 107 mg of methyl (2S)-3-(4-((2,6-dichlorophenyl)carbonylamino)-2-oxohydropyrimidinyl)-2-((2-methyl-5-nitrophenyl)carbonylamino)propionate (245) (yield: 98%). LR-MS (m/z): 546 [(M-H)-] IR (KBr): 3263, 3078, 2956, 1719, 1663, 1561, 1491, 1433, 1348, 1304, 1243, 1194, 1135, 1079, 1042, 1007, 902 cm-1 1H-NMR (300MHz, CD3OD, δppm): 2.53(3H, s), 3.79(3H, s), 4.38-4.57(2H, m), 5.01-5.08(1H, m), 7.33-7.37(4H, m), 7.54(1H, d, J= 7.5 Hz), 7.82(1H, d, J= 7.5 Hz), 8.12(1H, dd, J= 2.4, 8.1 Hz), 8.26(1H, s), 8.28(1H, d, J= 2.7 Hz), 8.87(1H, s) [α]D20= -120° (c = 0.048, CH3OH)

Reference： [1]Current Patent Assignee: TORAY INDUSTRIES INC - EP1209147, 2002, A1

26
[ 39959-51-8 ]
[ 21900-37-8 ]
[ 1021434-08-1 ]

Reference： [1]Chemistry - A European Journal,2008,vol. 14,p. 1238 - 1252

27
[ 1020154-02-2 ]
[ 21900-37-8 ]
[ 1020154-56-6 ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	48 λ/-Ethyl-2.6-dimethyl-λ/-[3.3.3-trifluoro-2-αϖ-(4-fluorophenylV1 H-indazol-4- yllamino)methyl)-2-hvdroxypropyllbenzamide3-(Ethylamino)-1 ,1 ,1 -trifluoro-2-([1 -(4-fluorophenyl)-1 H-indazol-4-yl]amino}methyl)-2- propanol (25mg, 0.063mmol) was dissolved in anhydrous dichloromethane (0.15ml). N, N- diisopropylethylamine (0.01 1 ml, 0.13mmol) was then added followed by 2,6- dimethylbenzoyl chloride in DCM (10.6mg, 0.065mmol as a 10Oμl aliquot of 80.8mg in 0.76ml DCM) and the mixture stirred at room temperature overnight. The mixture was diluted with dichloromethane, washed successively with aqueous sodium bicarbonate and water and then dried through a hydrophobic frit and evaporated and the crude product purified by mass directed autopreparation (System B). Product containing fractions were partitioned between dichloromethane and aqueous sodium bicarbonate. The aqueous layer was re-extracted with dichloromethane and the combined organic extracts were washed successively water and brine, dried through a hydrophobic frit and evaporated in vacuo to give the title compound (13.1 mg). LCMS: tRET = 3.99 min; MH+ = 529

Reference： [1]Current Patent Assignee: GLAXOSMITHKLINE PLC - WO2008/43789, 2008, A1 Location in patent: Page/Page column 88-89

28
[ 894401-36-6 ]
[ 21900-37-8 ]
(E)-2-(2,6-dimethylbenzamido)-5-[4-(methyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid methyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine In dichloromethane at 20℃; for 3h;	68 Under an argon atmosphere, oxalyl dichloride (0.025 ml) and DMF (0.002 ml) were added to a solution of 2,6-dimethylbenzoic acid (24 mg) in dichloromethane (1.0 ml), and the resulting mixture was stirred at room temperature for 2 hours. The reaction solution was concentrated and the residue was dissolved in dichloromethane (1.0 ml). To the solution, 2-amino-5-[4-(methyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid methyl ester (50 mg) and triethylamine (0.05 ml) were added, and the resulting mixture was stirred at room temperature for 3 hours. To the reaction solution, 1N hydrochloric acid was added, and the resulting solution was extracted with dichloromethane, followed by drying the organic layer over anhydrous sodium sulfate. After removing anhydrous sodium sulfate by filtration, the filtrate was concentrated. The residue was purified by thin layer chromatography (silica gel, developing solvent: hexane/ethyl acetate = 3/2) to obtain (E)-2-(2,6-dimethylbenzamido)-5-[4-(methyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid methyl ester (62 mg).

Reference： [1]Current Patent Assignee: TORAY INDUSTRIES INC - EP2039687, 2009, A1 Location in patent: Page/Page column 71-72

29
[ 121-71-1 ]
[ 21900-37-8 ]
[ 1174130-58-5 ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine In dichloromethane at 20℃; for 16h; Inert atmosphere;	1.B Step B: Preparation of 3-Acetylphenyl 2,6-dimethylbenzoate:; To a stirred solution of 3'-Hydroxyacetophenone (4.84 g, 35.5 mmol) in anhydrous CH2Cl2 (50 ml) was added at room temperature pyridine (25 ml) followed by addition of 2,6- Dimethylbenzoyl chloride (Step A, 6 g, 35 mmol) in anhydrous CH2Cl2 (10 ml) under argon. The reaction mixture was stirred for 16 hours, concentrated under reduced pressure, diluted with CH2Cl2, and washed with .1M HCl, water and brine. The organic layer was dried over Na2SO4, concentrated and purified by flash chromatography eluted with ethyl acetate: hexane (1 :2) to give the title compound.1H NMR (270 MHz, CDCl3): 2.5 (s, 6H); 2.6 (s, 3H); 7.1 (m, 2H); 7.25 (m, IH); 7.4-7.6 (m, 2H); 7.8-7.9 (m, 2H).

Reference： [1]Current Patent Assignee: WELLSTAT GROUP OF COMPANIES - WO2009/91732, 2009, A1 Location in patent: Page/Page column 26-27

30
C₈H₁₆N₂ [ No CAS ]
[ 21900-37-8 ]
[ 872002-02-3 ]

Yield	Reaction Conditions	Operation in experiment
8%	Stage #1: C₈H₁₆N₂ With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 0.25h; Stage #2: 2,6-dimethylbenzoyl chloride In tetrahydrofuran; hexane at 0℃; for 0.25h;	37.1 Butyllithium 2.5M in hexanes (2 mL, 5 mmol) was added dropwise at 0° C to a suspension of 110 (0.35 g, 3 mmol, prepared as described in J. Org. Chem. 1996, 61:8897- 8903) () in THF (8 mL). The resulting mixture was stirred at 0° C for 15 min then 2,6- dimethyl-benzoyl chloride (0.421 g, 3 mmol) in THF (2mL) was added. The reaction mixture was stirred at 0° C for 15 min then quenched by addition of MeOH (7 mL) and evaporated. The residue was partitioned between EtOAc and water. The organic layer was dried (MgS04), filtered and evaporated. The residue was purified by flash chromatography on silica gel eluting with a gradient from 100% DCM to a 1:1 1 solution of DCM and DCM/MeOH/NH40H 80/10/1 to afford 52 mg (8%) of 111: ¹H NMR (CDC13) 8 1.01 (s, 3H), 1.11 (s, 3H), 2.26 (s, 6H), 2.83 (d, 1H, J-- 12 Hz), 2.90 (d, 1H, J= 12 Hz), 2.95 (d, 1H, J= 12 Hz), 2.96 (d, 1H, J= 12 Hz), 3.09 (d, 1H, J= 12 Hz), 3.15 (d, 1H, J= 12 Hz), 3.54 (d, 1H, J= 12 Hz), 3.84 (d, 1H, J= 12 Hz), 7.03 (bd, 2H, J= 9 Hz), 7.15 (dd, 1H, J= 9; 8 Hz) ; MS (ES+) m/z 273 (M + H)+.

Reference： [1]Current Patent Assignee: ROCHE HOLDING AG - WO2005/121145, 2005, A2 Location in patent: Page/Page column 166-167

31
4-((R*)-((R)-1,1-dimethylethylsulfinamido)(2-methyl-2-azabicyclo[2.2.2]octan-1-yl)methyl)-N,N-dimethylbenzenesulfonamide [ No CAS ]
[ 21900-37-8 ]
(R*)-N-((4-(N,N-dimethylsulfamoyl)phenyl)(2-methyl-2-azabicyclo[2.2.2]octan-1-yl)methyl)-2,6-dimethylbenzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 4-((R*)-((R)-1,1-dimethylethylsulfinamido)(2-methyl-2-azabicyclo[2.2.2]octan-1-yl)methyl)-N,N-dimethylbenzenesulfonamide With hydrogenchloride In 1,4-dioxane; methanol at 20℃; for 0.0833333h; Stage #2: 2,6-dimethylbenzoyl chloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;	5.D Step D. Preparation of (R)-N-((4-(N,N-dimethylsulfamoyl)phenyl)(2- methyl-2-azabicyclo [2.2.2] octan-l-yl)methyl)-2,6-dimethylbenzamide from 4-((R)-((R)- l,l-dimethylethylsulfinamido)(2-methyl-2-azabicyclo[2.2.2]octan-l-yl)methyl)-N,N- dimethylbenzenesulfonamide.; A solution of 4-((R)-((R)- 1 , 1 -dimethylethylsulfmamido)(2-methyl-2-azabicyclo[2.2.2]octan- l-yl)methyl)-N,N-dimethylbenzenesulfonamide (0.053 g, 0.12 mmol) in methanol (3 niL) was treated with 4.0 M hydrochloric acid in dioxane (1 mL, 4.00 mmol). The resulting solution was stirred at room temperature for 5 min and was then concentrated. The resulting residue was taken up in dichloromethane (2 mL) and sequentially treated with DIPEA (0.105 mL, 0.60 mmol) and 2,6-dimethylbenzoyl chloride (0.180 mL, 0.18 mmol). The reaction was stirred at room temperature for 16 h and then concentrated. This new residue was diluted with acetonitrile, filtered, and purified by preparative HPLC (C 18, acetonitrile in water containing ammonium carbonate, pH 10) to afford semi-pure product. This white solid was repurified by flash column chromatography (SiO2, 0-100% ethyl acetate in hexanes) to afford (R)-N-((4- (N,N-dimethylsulfamoyl)phenyl)(2-methyl-2-azabicyclo[2.2.2]octan-l-yl)methyl)-2,6- dimethylbenzamide (0.018 g, 31.9%) as a colorless glass. IH NMR (500 MHz, chloroform-d) δ ppm l.18 - 1.29 (m, I H), 1.36 - 1.49 (m, 3 H), 1.58 - 1.71 (m, 4 H), 1.93 - 2.04 (m, I H), 2.34 (s, 6 H), 2.41 (s, 3 H), 2.48 - 2.55 (m, 1 H), 2.74 (s, 6 H), 3.17 - 3.26 (m, 1 H), 4.92 (s, 1 H), 6.97 (br. s., 1 H), 7.03 (d, J=7.3 Hz, 2 H), 7.17 (t, J=7.5 Hz, 1 H), 7.49 (d, J=7.9 Hz, 2 H), 7.73 (d, J=8.2 Hz, 2 H). m/z (ES+), (M+H)+ = 470.4; MSl, HPLC tR = 0.49 min.

Reference： [1]Current Patent Assignee: ASTRAZENECA PLC - WO2010/87761, 2010, A1 Location in patent: Page/Page column 67

32
[ 1236548-17-6 ]
[ 21900-37-8 ]
[ 1236548-19-8 ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃;	9.C Step C. Preparation of tert-butyl l-((2,6-dimethylbenzamido)(5- methylfuran-2-yl)methyl)-7-azabicyclo[2.2.1]heptane-7-carboxylate from tert-butyl 1- (amino(5-methylfuran-2-yl)methyl)-7-azabicyclo [2.2.1 ] heptane- 7-carboxylateTo a round bottom flask was added tert-butyl l-(amino(5-methylfuran-2-yl)methyl)-7- azabicyclo[2.2.1]heptane-7-carboxylate (1.38 g, 4.51 mmol) dissolved in CH2Cl2 (18.0 mL) and cooled to O0C. Next DIPEA (1.965 mL, 11.28 mmol) was added followed by the dropwise addition of a solution of 2,6-dimethylbenzoyl chloride (0.837 g, 4.96 mmol) in CH2Cl2 (2.0 niL). The reaction was stirred at O0C for 20 hr. It was added to a separatory funnel along with water, saturated NaCl and CH2Cl2. The organic was collected and the aq. extracted 2X more with CH2Cl2. The combined organics were dried over Na2SO4 and rotovaped. This material was redissolved in Et2O, adsorped onto silica gel and purified by silica gel column chromatography to afford tert-butyl l-((2,6-dimethylbenzamido)(5-methylfuran-2-yl)methyl)- 7-azabicyclo[2.2.1]heptane-7-carboxylate (1.56g, 79%). m/z (ES+), (M+H)+ = 439; MS7, HPLC tR = 6.81 min.

Reference： [1]Current Patent Assignee: ASTRAZENECA PLC - WO2010/87762, 2010, A1 Location in patent: Page/Page column 90-91

33
[ 106670-33-1 ]
[ 21900-37-8 ]
[ 1234380-97-2 ]

Yield	Reaction Conditions	Operation in experiment
76%	With triethylamine In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere;	Typical Procedure for Amidation of 2,6-Disubstituted Benzoic Acids Through Acid Chloride Formation Typical Procedure for Amidation of 2,6-Disubstituted Benzoic Acids Through Acid Chloride Formation (Synthesis of N-[2-(3-chloro-benzylsulfanyl)-ethyl]-2,6-dimethyl-benzamide, 75 as representative example). One drop of DMF was added to a solution of 2,6-dimethylbenzoic acid (0.3 g, 2 mmol) in thionyl chloride (2 mL), and the mixture was refluxed for 2 h. It was then cooled to room temperature and the excess thionyl chloride was removed in vacuo. The solid residue was dissolved in dry DCM (5 mL) and cooled to 0° C. A mixture of β-(3-chlorobenzyl)mercaptoethylamine (0.404 g, 2 mmol) and triethylamine (1 mL, 7 mmol) in dry DCM (5 mL) was added in dropwise manner at 0° C. under nitrogen atmosphere, and the mixture was allowed to stir at room temperature for 1.5 h. After the completion of reaction (as judged by TLC) the solvent was removed in vacuo and the solid residue was dissolved in DCM (30 mL). The organic phase was washed with brine (15 mL) and water (15 mL), dried over Na2SO4, and concentrated in vacuo. The crude residue was purified by silica gel column chromatography using a mixture of hexane/ethyl acetate (gradient from 15% v/v ethyl acetate/hexane to 35% v/v ethyl acetate/hexane) as eluent to obtain the desired amidated product, 75 (0.507 g, 76%): mp=53-55° C. 1H NMR (CDCl3, 400 MHz): δ 2.27 (s, 6H), 2.65 (t, J=6.4 Hz, 2H), 3.57 (q, J=6.4 Hz, 2H), 3.69 (s, 2H), 6.06 (bs, 1H), 6.99 (d, J=7.6 Hz, 2H), 7.14 (t, J=7.6 Hz, 1H), 7.19-7.23 (m, 3H), 7.32 (s, 1H). 13C NMR (CDCl3, 100 MHz): δ 19.41, 31.42, 35.46, 38.11, 127.27, 127.65, 127.71, 128.96, 129.12, 130.07, 134.39, 134.65, 137.61, 140.32, 170.61. HRMS calculated for C18H21ClNOS (M+H)+ 334.10324, found 334.10221.
0.507 g	With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;

Reference： [1]Current Patent Assignee: CLEVELAND CLINIC - US2013/158112, 2013, A1 Location in patent: Paragraph 0080
[2]Location in patent: experimental part Chakrabarti, Enakshi; Ghosh, Subrata; Sadhukhan, Sushabhan; Sayre, Lawrence; Tochtrop, Gregory P.; Smith, Jonathan D. [Journal of Medicinal Chemistry, 2010, vol. 53, # 14, p. 5302 - 5319]

34
[ 1174376-35-2 ]
[ 21900-37-8 ]
N'-[1-(2,6-dimethylbenzoyl)-5-fluoro-2-oxo-1,2-dihydro-pyrimidin-4-yl]-N,N-dimethylformamidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
37%	With pyridine at 40℃; for 2h;	2 To an 8 mL screw-cap vial were added pyridine (2 mL), N'-(5-fluoro-2-hydroxy-pyrimidin-4-yl)-N,N-dimethylformamidine (100 mg, 0.54 mmol), and 2,6-dimethylbenzoyl chloride (102 mg, 0.60 mmol). The mixture was heated to 40° C. for 2 h, evaporated to dryness, and partitioned between ethyl acetate (EtOAc) and water (H2O). The organic phase was dried over magnesium sulfate (MgSO4), filtered, evaporated, and the residue was purified by reverse phase chromatography to yield the title compound as a white solid (63 mg, 37%): mp 120-150° C.; 1H NMR (300 MHz, CDCl3) δ 8.81 (s, 1H), 8.22 (d, J=6.04 Hz, 1H), 7.23-7.17 (m, 1H), 7.07-7.01 (m, 2H), 3.27 (s, 3H), 3.24 (s, 3H), 2.24 (s, 6H); ESIMS m/z 317 ([M+H]+).

Reference： [1]Current Patent Assignee: SINOCHEM HOLDINGS CORPORATION LTD - US2011/34490, 2011, A1 Location in patent: Page/Page column 8-9

35
2-(1-(2-fluorobenzyl)-5-(oxazol-2-yl)-1H-pyrazol-3-yl)pyrimidine-4,5-diamine hydrochloride [ No CAS ]
[ 21900-37-8 ]
C₂₆H₂₂FN₇O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
39.7%	With pyridine In dichloromethane	10 Compound 1-220[00449] Compound 1-220 was synthesized as a solid (39.7%) via the condensation of Compound 1-149 (1 equiv) and 2,6-dimethylbenzoyl chloride (1.5 equiv) with a catalytic amount of dimemylaminopyridine in a 2:1 solution of dichloromethane and pyridine.Purification was carried out by triturating the reaction mixture with water and ethyl ether.1H NMR (400 MHz, CD3OD) 8.77 (d, IH), 8.72 (s, IH), 7.47 (s, IH), 7.23 - 7.29 (m, 2H), 7.03 - 7.14 (m, 4H), 6.86 - 6.89 (m, 2H), 5.97 (s, 2H), 2.42 (s, 6H).

Reference： [1]Current Patent Assignee: CYCLERION THERAPEUTICS INC - WO2012/3405, 2012, A1 Location in patent: Page/Page column 238

36
[ 1383342-63-9 ]
[ 21900-37-8 ]
2,6-dimethyl-N-[1-(5-methyl-1H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]benzamide hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine; 2,6-dimethylbenzoyl chloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 67h; Stage #2: With hydrogenchloride In water	31 To a mixture of l-(5-methyl-7H-pyn-olo[2,3-^pyrimidin-4-yl)-4-piperidinardne (Dlla) (60 mg) and 2,6-dimethylbenzoyl chloride (40.5 mg, 0.240 mmol, commercially available from e.g. fluorochem or butt park) in Dichloromethane (DCM) (1 mL) at 0 °C was added N,N- diisopropylethylamine (0.063 mL, 0.361 mmol) and the mixture stirred at room temperature for 6 h. LCMS showed incomplete reaction plus by-products. Further 2,6-dimethylbenzoyl chloride (40.5 mg, 0.240 mmol) and N,N-diisopropylethylamine (0.063 mL, 0.361 mmol) were added and the reaction stirred for lh and allowed to stand for 60 h (over weekend. The solvent was removed in vacuo and the crude product purified by MDAP to give 20 mg of product. This was very insoluble and was dissolved in 2M HC1 followed by evaporation of the solvent to form the hydrochloride salt of E31 as a bright pink solid in 15 mg. LCMS [M+H]+ 364.16 (at) 0.71 min ( 2 min run)

Reference： [1]Current Patent Assignee: GALAPAGOS - WO2012/80735, 2012, A1 Location in patent: Page/Page column 65

37
[ 77573-43-4 ]
[ 21900-37-8 ]
[ 1383427-36-8 ]

Yield	Reaction Conditions	Operation in experiment
	With dmap; N-ethyl-N,N-diisopropylamine In acetonitrile at 150℃; for 0.333333h; Microwave irradiation;	A mixture of acyl chloride (0.125 mmol), diisopropylethylamine (0.250 mmol), 4-(N,N- dimethylamino)-pyridine (0.025 mmol) and ingenol-5,20-acetonide (0.050 mmol) were stirred in a microwave oven at 150 °C in acetonitrile for 20 min. The mixture was mixed with ethyl acetate, filtered and washed with saturated aqueous sodium chloride. The organic phase was dried with sodium sulphate, concentrated in vacuo and purified by flash chromatography (heptane→ heptane/ethyl acetate 7:3), giving the title compound as a white solid. Compound 415 was prepared according to Procedure d.Starting material : 2,6-Dimethyl-benzoyl chloride. 1H NMR (300 MHz, CDCI3) δ 7 '.22-7.17 (m, IH), 7.05-7.02 (d, 2H), 6.09 (s, IH), 5.82- 5.81 (m, 2H), 4.28-4.09 (m, 4H), 3.39 (s, IH), 2.57-2.51 (m, IH), 2.36 (s, 6H), 2.32- 2.21 (m, IH), 1.84 (d, 3H), 1.75-1.66 (m, IH), 1.50 (s, 3H), 1.48 (s, 3H), 1.09 (s, 3H),3H), 0.90-0.85 (m, IH), 0.72-0.64 (m, IH).

Reference： [1]Current Patent Assignee: LEO FONDET - WO2012/83954, 2012, A1 Location in patent: Page/Page column 41; 47-48

38
[ 1426833-20-6 ]
[ 21900-37-8 ]
[ 1426833-33-1 ]

Yield	Reaction Conditions	Operation in experiment
114 mg	With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;	Ia4 Example Ia4 1-(2,6-Dimethyl-phenyl)-4-methyl-2,3,5,6,9b-pentaazacyclopenta[a]naphthalene. To a mixture of Ila (100 mg), DIPEA (0.2 mL) in DMF (2 mL) was added 2,6-dimethyl benzoyl chloride (96 mg), and the mixture was stirred at ambient temperature for 5min. The volatiles were removed in vacuo. The residue was purified by preparative TLC (eluent: DCM/methanol 20/1) to give the corresponding hydrazide (1 14 mg). 45 mg of this material was suspended in acetonitrile (2 mL) and treated with DIPEA (0.2 mL) for 5 min and then with PhPOCl2 (0.1 1 mL). The mixture was purified directly by preparative TLC (eluent: pentane/EtOAc 1/1) to afford example Ia4 (7.2 mg). LC/MS (method 132): RT(PDA)=1.54 min; PDA / ELS-purities 98.0% / 100%; mass observed 290.0.

Reference： [1]Current Patent Assignee: H. LUNDBECK A/S - WO2013/34761, 2013, A1 Location in patent: Page/Page column 21

39
[ 1426833-27-3 ]
[ 21900-37-8 ]
[ 1426833-37-5 ]

Yield	Reaction Conditions	Operation in experiment
45 mg	With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;	Id3 Example Id3 l -(2,6-Dimethyl-phenyl)-4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalene. To a mixture of lid (50 mg), DIPEA (0.2 mL) in DMF (2 mL) was added 2,6-dimethyl benzoyl chloride (48 mg), and the mixture was stirred for 5 min at ambient temperature. The volatiles were removed in vacuo. The residue was purified by preparative TLC (eluent: DCM/methanol 20/1) to afford the corresponding hydrazide (45 mg). This material was mixed with acetonitrile (2 mL) and DIPEA(0.2 mL) and treated with PhPOC . (0.04 mL) for 3 min at ambient temperature. The volatiles were removed in vacuo. The residue was purified by preparative TLC (eluent: DCM/methanol 30/1) to afford example Id3 (12 mg). LC/MS (method 132): RT(PDA) = 1.78 min; PDA purity 100%; mass observed 290.0.

Reference： [1]Current Patent Assignee: H. LUNDBECK A/S - WO2013/34761, 2013, A1 Location in patent: Page/Page column 23

40
(S)-N-(1-phenylethyl)propionamide [ No CAS ]
[ 21900-37-8 ]
(S)-N-propionyl-N-(1-phenylethyl)-2,6-dimethylbenzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
23%	With triethylamine In toluene for 3.5h; Reflux;	General procedure for imide synthesis General procedure: The corresponding amide 15 mmol (1equiv.) was dissolved in 75 mL of toluene. It were added 2.9 mL (21 mmol, 1.4equiv.) of triethylamine and 2.1 mL (18 mmol, 1.2 equiv.) of benzoylchloride to the solution. The reaction mixture was heated to refluxfor 3.5 hours. It was cooled to room temperature and diluted with 30 mL ofEtOAc, washed with 50 mL of sodium bicarbonate, 50 mL of HCl 1 M, and 50 mL ofbrine. It was dried and concentrated. The product was purified by flashchromatography with a mixture hexane/EtOAc (10:0 to 9:1).

Reference： [1]Garduño-Castro, Monserrat H.; Hernández-Rodríguez, Marcos [Tetrahedron Letters, 2014, vol. 55, # 1, p. 193 - 196]

41
[ 62-53-3 ]
[ 21900-37-8 ]
[ 17386-88-8 ]

Yield	Reaction Conditions	Operation in experiment
85%	With triethylamine In dichloromethane at 0 - 20℃;
4.9 g	With triethylamine In dichloromethane at 0℃;	2.1 Step 1) 2,6-dimethyl-N-phenylbenzamide To a suspension of 2,6-dimethyl benzoic acid (5.0 g, 33.29 mmol) in toluene (100 was added SOCl12 (12.08 mL, 166.47 mmol) at rt. The reaction was stirred at reflux overnight, then cooled to rt and concentrated in vacuo. The residue was dissolved in DCM (50 mL), and the solution was used for the next step directly. [0509] To a mixture of triethylamine (6.73 g, 66.54 mmol) and aniline (3.10 g, 33.27 mmol) in DCM (50 mL) at 0° C. was added the above solution dropwise, followed by adding water (100 mL). The separated organic phase was washed with water (100 mL×2) and brine (50 mL), dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (v/v)=6/1) to give the title compound as a pale yellow solid (4.9 g, 65.4%). [0510] MS (ESI, pos. ion) mz: 226.3 [M+H]+; [0511] 1H NMR (600 MHz, DMSO-d6) δ (ppm): 10.37 (s, 1H), 7.74 (d, J=7.6 Hz, 2H), 7.34 (t, J=7.9 Hz, 2H), 7.24 (t, J=7.6 Hz, 1H), 7.17-7.01 (m, 3H), 2.28 (s, 6H); [0512] 13C NMR (151 MHz, DMSO-d6) δ (ppm): 168.36 (s), 139.56 (s), 138.94 (s), 134.13 (s), 129.20 (s), 128.86 (s), 127.73 (s), 124.06 (s), 120.03 (s), 19.33 (s).
740 mg	With sodium hydrogencarbonate In 1,4-dioxane; water at 0 - 20℃;	20.1 Step 1) 2,6-dimethyl-N-phenylbenzamide [379] To a mixture of 2,6-dimethylbenzoic acid (1.99 g, 13.3 mmol) and N,N- dimethylformamide (103 mg, 1.409 mmol) in dichloromethane (15 mL) was added oxalyl di chloride (2.25 mL) at rt. The reaction was stirred at rt for 4 hours, then concentrated in vacuo, and the residue was dissolved in 4 mL of 1,4-dioxane. The resulted solution was added to a mixture of aniline (1.28 g, 13.7 mmol) and sodium bicarbonate (2.80 g, 175 mmol) in 1,4- dioxane (11 mL) and water (7 mL) at 0 °C, then moved to rt, and stirred overnight. The mixture was poured into 0 (100 mL), and extracted with EtOAc (50 mL χ 2). The combined organic phase was concentrated in vacuo, and the residue was purified by a silica gel column chromatography (PE EtOAc (v/v) = 10/1) to give the title compound as an off-white solid (740 mg, 25%). MS (ESI, pos. ion) m/z: 226.0 [M+H]+; NMR (400 MHz, CDCb) δ (ppm): 7.63-7.61 (d, J = 8.0 Hz, 2H), 7.39-7.36 (dd, J = 8.0, 8.0 Hz, 2H), 7.36 (br s, 1 H), 7.23-7.13 (m, 2H), 7.08-7.06 (d, J= 7.6 Hz, 2H), 2.40 (s, 6H).

Reference： [1]Verma, Ajay; Patel, Saket; Meenakshi; Kumar, Amit; Yadav, Abhimanyu; Kumar, Shailesh; Jana, Sadhan; Sharma, Shubham; Prasad, Ch. Durga; Kumar, Sangit [Chemical Communications, 2015, vol. 51, # 7, p. 1371 - 1374]
[2]Current Patent Assignee: SHENZHEN DONGYANGGUANG INDUSTRIAL DEVELOPMENT CO LTD - US2015/87658, 2015, A1 Location in patent: Paragraph 0509-0512
[3]Current Patent Assignee: CALITOR SCIENCES LLC; SHENZHEN DONGYANGGUANG INDUSTRIAL DEVELOPMENT CO LTD - WO2016/149160, 2016, A1 Location in patent: Paragraph 379

42
[ 765-30-0 ]
[ 21900-37-8 ]
N-cyclopropyl-2,6-dimethylbenzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
4 g	With triethylamine In dichloromethane at 0 - 20℃;	6.1 Step 1) N-cyclopropyl-2,6-dimethylbenzamide To a suspension of 2,6-dimethylbenzoic acid (4.0 g, 26.64 mmol) in toluene (30 mL) was added SOCl2 (8.0 mL, 106.54 mmol) at rt. The reaction was stirred at 90° C. overnight, then cooled down to rt, and concentrated in vacuo. The residue was dissolved in 30 mL of DCM, then to the solution were added NEt3 (14.85 mL, 106.54 mmol) and cyclopropanamine (2.03 mL, 29.30 mmol) dropwise at 0° C. The resulted solution was stirred at rt for 2 hours, and quenched with 50 mL of saturated brine. The separated organic phase was washed with 100 mL of saturated NaHCO3 aqueous solution, and 100 mL of saturated brine, dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (v/v) 4/1) to give the title compound as an off-white solid (4.0 g, 80%). [0555] 1H NMR (400 MHz, CDCl3) δ (ppm): 7.14-7.10 (dd, J=7.6, 7.6 Hz, 1H), 6.99-6.97 (d, J=7.6 Hz, 2H), 5.81 (br. s, 1H), 3.92-2.86 (m, 1H), 2.28 (s, 6H), 0.88-0.84 (m, 2H), 0.60-0.56 (m, 2H).
1.35 g	With triethylamine In dichloromethane at 20℃; Inert atmosphere;	23.1 Step 1) N-cvclopropyl-2.6-dimethylbenzamide [386] To a solution of 2,6-dimethylbenzoic acid (2.06 g, 13.7 mmol) in DCM (10 mL) was added oxalyl dichloride (2.3 mL, 27 mmol) at room temperature, the reaction was stirred at 45 °C for 5 hours, then cooled to room temperature, and concentrated in vacuo. The residue was dissolved in DCM (20 mL) and to the resulted solution was added Et3N (5.5 mL, 40 mmol) and cyclopropanamine (1 mL, 14.4 mmol) at room temperature. The resulted solution was stirred at room temperature overnight. The reaction was washed with H20 (100 mL χ 2), saturated NaHC03 aqueous solution (100 mL χ 2) and saturated brine (100 mL). The separated organic phase was dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified by a silica gel column chromatography (EtOAc PE (v/v) = 1/4) to give the title compound as a white solid (1.35 g, 52%). MS (ESI, pos. ion) m/z: 190.1 [M+H]+; NMR (400 MHz, DMSO-tfc) δ (ppm): 8.30 (s, 1H), 7.19-7.09 (m, 1H), 7.02 (d, J = 7.5 Hz, 2H), 2.81 (m, 1H), 2.18 (s, 6H), 0.72-0.61 (m, 2H), 0.52-0.43 (m, 2H).

Reference： [1]Current Patent Assignee: SHENZHEN DONGYANGGUANG INDUSTRIAL DEVELOPMENT CO LTD - US2015/87658, 2015, A1 Location in patent: Paragraph 0554; 0555
[2]Current Patent Assignee: CALITOR SCIENCES LLC; SHENZHEN DONGYANGGUANG INDUSTRIAL DEVELOPMENT CO LTD - WO2016/149160, 2016, A1 Location in patent: Paragraph 386

43
(Z)-4-((4-chlorobenzyl)oxy)-N'-hydroxybenzimidamide [ No CAS ]
[ 21900-37-8 ]
(Z)-4-((4-chlorobenzyl)oxy)-N'-((2,6-dimethylbenzoyl)oxy)benzimidamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
135 mg	With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 48h;	40 Diisopropylethylamine (68 μL, 0.389 mmol) was added to a mixture of crude 2,6-dimethylbenzoyl chloride (60 mg, 0.356 mmol, prepared as described previously for Intermediate 5a) and (Z)-4-((4-chlorobenzyl)oxy)-N'-hydroxybenzimidamide (98 mg, 0.354 mmol) in THF (3 mL). After stirring for 48 h at room temperature, the standard isolation procedure gave a crude residue was swished overnight in ether-pentane to give 135 mg (93%) of (Z)-4-((4-chlorobenzyl)oxy)-N'-((2,6-dimethylbenzoyl)oxy)benzimidamide as a white solid: 1H NMR (400 MHz, DMSO-d6)_ppm 2.29 (s, 6H) 5.17 (s, 2H) 6.72 (br. s., 2H) 7.07 (m, J=9.00 Hz, 2H) 7.11 (d, J=7.43 Hz, 2H) 7.22-7.29 (m, 1H) 7.42-7.53 (m, 4H) 7.69 (m, J=9.00 Hz, 2H); MS m/z 409.1329 (MH+); HPLC >99%, Rt 2.191 min, column 2.

Reference： [1]Current Patent Assignee: VIROCURA THERAPEUTICS - US2015/133495, 2015, A1 Location in patent: Paragraph 0206

44
(Z)-N'-hydroxy-4-(1,2,3-thiadiazol-4-yl)benzimidamide [ No CAS ]
[ 21900-37-8 ]
(Z)-N'-((2,6-dimethylbenzoyl)oxy)-4-(1,2,3-thiadiazol-4-yl)benzimidamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
63 mg	With triethylamine In tetrahydrofuran at 20℃; for 18.5h;	42 Triethylamine (0.040 mL, 0.285 mmol) was added to a mixture of (Z)-N'-hydroxy-4-(1,2,3-thiadiazol-4-yl)benzimidamide (0.052 g, 0.237 mmol) and 2,6-dimethylbenzoyl chloride (0.04 g, 0.237 mmol) in THF (1.5 mL) to give a white suspension. After stirring the mixture at room temperature for 18.5 h. the standard isolation protocol gave a white solid which was crystallized from EtOAc (2 mL). Filtration and drying at 40° C. under high vacuum afforded (Z)-N'-((2,6-dimethylbenzoyl)oxy)-4-(1,2,3-thiadiazol-4-yl)benzimidamide (63 mg, 75% yield) as a white solid: 1H NMR (400 MHz, DMSO-d6)_ppm 2.32 (s, 6H) 6.94 (br. s., 2H) 7.14 (d, J=7.43 Hz, 2H) 7.24-7.32 (m, 1H) 7.90-7.97 (m, 2H) 8.20-8.28 (m, 2H) 9.75 (s, 1H); MS m/z 353.1062 (MH+); HPLC 100%, Rt 5.48 min, column 2.

Reference： [1]Current Patent Assignee: VIROCURA THERAPEUTICS - US2015/133495, 2015, A1 Location in patent: Paragraph 0208

45
(Z)-2-(2,4-dimethoxyphenyl)-N'-hydroxyacetimidamide [ No CAS ]
[ 21900-37-8 ]
(Z)-2-(2,4-dimethoxyphenyl)-N'-((2,6-dimethylbenzoyl)oxy)acetimidamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
100 mg	With triethylamine In tetrahydrofuran at 20℃; for 1h;	39 Triethylamine (0.109 mL, 0.780 mmol) was added to a mixture of 2,6-dimethylbenzoyl chloride (65.8 mg, 0.390 mmol) and (Z)-2-(2,4-dimethoxyphenyl)-N'-hydroxyacetimidamide (82 mg, 0.390 mmol) in THF (2 mL). After stirring the suspension at room temperature for 1 h, the usual isolation procedure gave a solid residue which was purified by flash chromatography and then treated with a mixture of ether-pentane (with a trace of DCM) to give 100 mg (75%) of (Z)-2-(2,4-dimethoxyphenyl)-N'-((2,6-dimethylbenzoyl)oxy)acetimidamide as solid: 1H NMR (400 MHz, DMSO-d6)_ppm 2.24 (s, 6H) 3.31 (s, 2H) 3.75 (s, 3H) 3.79 (s, 3H) 6.21 (br. s., 2H) 6.50 (dd, J=8.41, 2.54 Hz, 1H) 6.56 (d, J=2.35 Hz, 1H) 7.081 (d, J=7.70 Hz, 1H) 7.083 (d, J=8.20 Hz, 1H) 7.14 (d, J=8.22 Hz, 1H) 7.23 (dd, J=7.83, 7.50 Hz, 1H); MS m/z 343.1624 (MH+); HPLC >99.5%, Rt 1.902 min, column 2.

Reference： [1]Current Patent Assignee: VIROCURA THERAPEUTICS - US2015/133495, 2015, A1 Location in patent: Paragraph 0205

46
[ 551-93-9 ]
[ 21900-37-8 ]
N-(2-acetylphenyl)-2,6-dimethylbenzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
95%	With triethylamine In dichloromethane at 0 - 20℃;

Reference： [1]Verma, Ajay; Kumar, Sangit [Organic Letters, 2016, vol. 18, # 17, p. 4388 - 4391]

47
[ 16856-13-6 ]
[ 21900-37-8 ]
C₁₄H₁₇NO₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine In dichloromethane at -10℃; for 2h;	Methyl [5-Methyl-2-(2,6-dimethylphenyl)oxazol-4-yl]acetate(16a) To a suspension of the 2,6-dimethylbenzoyl chloride14a (11.8 g, 70 mmol) and 15 (18.4 g, 100 mmol) in CH2Cl2(450 mL) was added triethylamine (27.8 mL, 200 mmol)dropwise at -10°C, and stirred at the same temperature for2 h. The reaction mixture was washed with water, 6 M HCland saturated brine, and dried over Na2SO4. The solvent wasevaporated under reduced pressure to give a crude oil (16.8 g).

Reference： [1]Otake, Kazuya; Azukizawa, Satoru; Takeda, Shigemitsu; Fukui, Masaki; Kawahara, Arisa; Kitao, Tatsuya; Shirahase, Hiroaki [Chemical and Pharmaceutical Bulletin, 2015, vol. 63, # 12, p. 998 - 1014]

48
[ 737745-17-4 ]
[ 21900-37-8 ]
N-(2-(2-cyanophenoxy)ethyl)-N,2,6-trimethylbenzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine In dichloromethane at 0 - 20℃;

Reference： [1]Fang, Lizhen; Saint-Denis, Tyler G.; Taylor, Buck L. H.; Ahlquist, Seth; Hong, Kai; Liu, Saisai; Han, Lili; Houk; Yu, Jin-Quan [Journal of the American Chemical Society, 2017, vol. 139, # 31, p. 10702 - 10714]

49
C₁₄H₁₃FN₂O₂ [ No CAS ]
[ 21900-37-8 ]
(Z)-N′-((2,6-dimethylbenzoyl)oxy)-2-((4-fluorobenzyl)oxy)benzimidamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
107 mg	With triethylamine In dichloromethane at 20℃; for 2h;	41 Triethylamine (0.098 mL, 0.706 mmol) was added to solution of crude 2,6-dimethylbenzoyl chloride (85 mg, 0.504 mmol, prepared from the corresponding acid following the procedure described for Intermediate 5a) and of (Z)-2-((4-fluorobenzyl)oxy)-N′-hydroxybenzimidamide (131 mg, 0.504 mmol) in DCM (3 mL). The reaction was stirred at room temperature for 2 h and the standard isolation procedure gave a crude product which was purified by flash chromatography to give 107 m g (54%) of (Z)-N′-((2,6-dimethylbenzoyl)oxy)-2-((4-fluorobenzyl)oxy)benzimidamide as a white solid: 1H NMR (400 MHz, DMSO-d6)_ppm 2.29 (s, 6H) 5.15 (s, 2H) 6.70 (s, 2H) 7.02 (td, J=7.43, 1.17 Hz, 1H) 7.07-7.13 (m, 2H) 7.13-7.21 (m, 3H) 7.21-7.27 (m, 1H) 7.40 (dd, J=7.63, 1.76 Hz, 1H) 7.42-7.48 (m, 1H) 7.52-7.61 (m, 2H); MS m/z 393.1631 (MH+); HPLC >99.5%, Rt 2.072 min, column 2.

Reference： [1]Current Patent Assignee: VIROCURA THERAPEUTICS - US2015/133495, 2015, A1 Location in patent: Paragraph 0207

50
2,2,4,4-tetramethylpentane-1,5-diol [ No CAS ]
[ 21900-37-8 ]
5-hydroxy-2,2,4,4-tetramethylpentyl 2,6-dimethylbenzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
69%	With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;	40.1 Step 1: Synthesis of 5-hydroxy-2,2,4,4-tetramethylpentyl 2,6-dimethylbenzoate (41a) To a stirred solution of 2,2,4,4-tetramethylpentane-1,5-diol (39c) (0.48 g, 3.0 mmol) and pyridine (0.24 mL, 3.0 mmol) in DCM (20 mL) was added 2,6-dimethylbenzoyl chloride (0.45 mL, 3.0 mmol) dropwise over the course of 30 min at 0° C. (ice bath) under an atmosphere of argon. The reaction mixture was stirred overnight at room temperature. The mixture was diluted with H2O (20 mL), and the layers were separated. The aqueous layer was extracted with DCM (2*20 mL), and the combined organic layers were washed with brine (20 mL), dried (Na2SO4), and concentrated under vacuum. The residue was purified by column chromatography on silica gel using EtOAc/hexanes (5:95 to 1:1) as eluent to give the product (41a) (462 mg, 53%) as an oil. 1H-NMR (300 MHz, CDCl3): δ 7.22-7.17 (m, 1H), 7.04 (d, J=7.5 Hz, 2H), 4.10 (s, 2H), 3.32 (s, 2H), 2.33 (s, 6H), 1.41 (s, 2H), 1.10 (s, 6H), 1.00 (s, 6H).
53%	With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;	41.1 Step 1: Synthesis of 5-hydroxy-2,2,4,4-tetramethylpentyl 2,6-dimethylbenzoate (41a) To a stirred solution of 2,2,4,4-tetramethylpentane-1,5-diol (39c) (0.48 g, 3.0 mmol) and pyridine (0.24 mL, 3.0 mmol) in DCM (20 mL) was added 2,6-dimethylbenzoyl chloride (0.45 mL, 3.0 mmol) dropwise over the course of 30 min at 0° C. (ice bath) under an atmosphere of argon. The reaction mixture was stirred overnight at room temperature. The mixture was diluted with H2O (20 mL), and the layers were separated. The aqueous layer was extracted with DCM (2×20 mL), and the combined organic layers were washed with brine (20 mL), dried (Na2SO4), and concentrated under vacuum. The residue was purified by column chromatography on silica gel using EtOAc/hexanes (5:95 to 1:1) as eluent to give the product (41a) (462 mg, 53%) as an oil. 1H NMR (300 MHz, CDCl3): δ 7.22-7.17 (m, 1H), 7.04 (d, J=7.5 Hz, 2H), 4.10 (s, 2H), 3.32 (s, 2H), 2.33 (s, 6H), 1.41 (s, 2H), 1.10 (s, 6H), 1.00 (s, 6H).
	With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;	66.1 Step 1: Synthesis of 5-hydroxy-2,2,4,4-tetramethylpentyl 2,6-dimethylbenzoate (66a) To a stirred solution of 406 2,2,4,4-tetramethylpentane-1,5-diol (61c) (0.48 g, 3.0 mmol) and 17 pyridine (0.24 mL, 3.0 mmol) in 188 DCM (20 mL) was added 419 2,6-dimethylbenzoyl chloride (0.45 mL, 3.0 mmol) dropwise over the course of 30 min at 0° C. (ice bath) under an atmosphere of argon. The reaction mixture was stirred overnight at room temperature. The mixture was diluted with H2O (20 mL), and the layers were separated. The aqueous layer was extracted with DCM (2×20 mL), and the combined organic layers were washed with brine (20 mL), dried (Na2SO4), and concentrated under vacuum. The residue was purified by column chromatography on silica gel using 21 EtOAc/hexanes (5:95 to 1:1) as eluent to give the 420 product (66a) (462 mg, 53%) as an oil. 1H-NMR (300 MHz, CDCl3): δ 7.22-7.17 (m, 1H), 7.04 (d, J=7.5 Hz, 2H), 4.10 (s, 2H), 3.32 (s, 2H), 2.33 (s, 6H), 1.41 (s, 2H), 1.10 (s, 6H), 1.00 (s, 6H).

Reference： [1]Current Patent Assignee: ARIXA PHARMACEUTICALS INC - US2020/102307, 2020, A1 Location in patent: Paragraph 1524-1526
[2]Current Patent Assignee: ARIXA PHARMACEUTICALS INC - US10085999, 2018, B1 Location in patent: Page/Page column 158
[3]Current Patent Assignee: ARIXA PHARMACEUTICALS INC - US2019/100516, 2019, A1 Location in patent: Paragraph 1250; 1251

51
[ 3121-82-2 ]
[ 21900-37-8 ]
5-hydroxy-3,3-dimethylpentyl 2,6-dimethylbenzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
25%	With pyridine at 0 - 20℃; for 3h; Inert atmosphere;	66.1 Step 1: Synthesis of 5-hydroxy-3,3-dimethylpentyl 2,6-dimethylbenzoate (66a) To a stirred solution of 2,2-dimethylpentane-1,5-diol (1.1 g, 8.3 mmol) in pyridine (8.3 mL) at 0° C. under an argon atmosphere was added 2,6-dimethylbenzoyl chloride in one portion. The reaction mixture was allowed to warm to room temperature for 3 h. The reaction was concentrated to dryness and EtOAc was added. The mixture was filtered and the filtrate was concentrated under vacuum. The residue was purified by column chromatography on silica gel using EtOAc/hexanes (0:1 to 1:4) as eluent to give the product (66a) (0.44 g, 25%) as an oil. 1H-NMR (300 MHz, CDCl3): δ 7.18 (t, J=7.7 Hz, 1H), 7.03 (d, J=7.5 Hz, 2H), 4.32 (t, J=6.3 Hz, 2H), 3.34 (s, 2H), 2.32 (s, 6H), 1.78-1.68 (m, 2H), 1.40-1.34 (m, 2H), 0.90 (s, 6H).

Reference： [1]Current Patent Assignee: ARIXA PHARMACEUTICALS INC - US2020/102307, 2020, A1 Location in patent: Paragraph 1661-1663

52
[ 126-30-7 ]
[ 21900-37-8 ]
3-hydroxy-2,2-dimethylpropyl 2,6-dimethylbenzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%	With pyridine; dmap In dichloromethane at 0 - 20℃; Inert atmosphere;	54.1 Step 1: Synthesis of 3-hydroxy-2,2-dimethylpropyl 2,6-dimethylbenzoate (54a) To a stirred solution of 2,2-dimethylpropane-1,3-diol (2.5 g, 24.3 mmol) in DCM (60 mL) at ca. 0° C. (ice bath) under an atmosphere of argon, was added 2,6-dimethylbenzoyl chloride (1.2 mL, 8.1 mmol), pyridine (1.1 mL, 13.7 mmol), and N,N-4-dimethylaminopyridine (99 mg, 0.8 mmol). The reaction mixture was allowed to gradually warm to room temperature and the mixture was stirred overnight. The reaction was quenched by the addition of 1N HCl, and the mixture was extracted with DCM (twice). The combined organic extracts were washed with a saturated aqueous solution of NaHCO3 and brine, dried (MgSO4), filtered and concentrated under vacuum. The residue was purified by column chromatography on silica gel using EtOAc/hexanes (1:9 to 2:3) as eluent to give the product (54a) (1.5 g, 78%) as an oil. 1H NMR (300 MHz, CDCl3): δ 7.21 (m, 1H), 7.04 (m, 2H), 4.18 (s, 2H), 3.41 (s, 2H), 2.32 (s, 6H), 2.20 (br. s, 1H), 0.99 (s, 6H).
78%	With pyridine; dmap In dichloromethane at 0 - 20℃; Inert atmosphere;	79.1 Step 1: Synthesis of 3-hydroxy-2,2-dimethylpropyl 2,6-dimethylbenzoate (79a) To a stirred solution of 16 2,2-dimethylpropane-1,3-diol (2.5 g, 24.3 mmol) in 188 DCM (60 mL) at ca. 0° C. (ice bath) under an atmosphere of argon, was added 419 2,6-dimethylbenzoyl chloride (1.2 mL, 8.1 mmol), 17 pyridine (1.1 mL, 13.7 mmol), and 18 N,N-4-dimethylaminopyridine (99 mg, 0.8 mmol). The reaction mixture was allowed to gradually warm to room temperature and the mixture was stirred overnight. The reaction was quenched by the addition of 1N 20 HCl, and the mixture was extracted with DCM (twice). The combined organic extracts were washed with a saturated aqueous solution of 184 NaHCO3 and brine, dried (MgSO4), filtered and concentrated under vacuum. The residue was purified by column chromatography on silica gel using 21 EtOAc/hexanes (1:9 to 2:3) as eluent to give the 532 product (79a) (1.5 g, 78%) as an oil. 1H-NMR (300 MHz, CDCl3): δ 7.21 (m, 1H), 7.04 (m, 2H), 4.18 (s, 2H), 3.41 (s, 2H), 2.32 (s, 6H), 2.20 (br. s, 1H), 0.99 (s, 6H).
78%	With pyridine; dmap In dichloromethane at 0 - 20℃; Inert atmosphere;	54.1 Step 1: Synthesis of 3-hydroxy-2,2-dimethylpropyl 2,6-dimethylbenzoate (54a) To a stirred solution of 2,2-dimethylpropane-1,3-diol (2.5 g, 24.3 mmol) in DCM (60 mL) at ca. 0° C. (ice bath) under an atmosphere of argon, was added 2,6-dimethylbenzoyl chloride (1.2 mL, 8.1 mmol), pyridine (1.1 mL, 13.7 mmol), and N,N-4-dimethylaminopyridine (99 mg, 0.8 mmol). The reaction mixture was allowed to gradually warm to room temperature and the mixture was stirred overnight. The reaction was quenched by the addition of 1N HCl, and the mixture was extracted with DCM (twice). The combined organic extracts were washed with a saturated aqueous solution of NaHCO3 and brine, dried (MgSO4), filtered and concentrated under vacuum. The residue was purified by column chromatography on silica gel using EtOAc/hexanes (1:9 to 2:3) as eluent to give the product (54a) (1.5 g, 78%) as an oil. 1H-NMR (300 MHz, CDCl3): δ 7.21 (m, 1H), 7.04 (m, 2H), 4.18 (s, 2H), 3.41 (s, 2H), 2.32 (s, 6H), 2.20 (br. s, 1H), 0.99 (s, 6H).

Reference： [1]Current Patent Assignee: ARIXA PHARMACEUTICALS INC - US10085999, 2018, B1 Location in patent: Page/Page column 184
[2]Current Patent Assignee: ARIXA PHARMACEUTICALS INC - US2019/100516, 2019, A1 Location in patent: Paragraph 1326; 1327
[3]Current Patent Assignee: ARIXA PHARMACEUTICALS INC - US2020/102307, 2020, A1 Location in patent: Paragraph 1605-1607

53
[ 10519-69-4 ]
[ 21900-37-8 ]
4-hydroxy-2,2,3,3-tetramethylbutyl 2,6-dimethylbenzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
266 mg	With pyridine; dmap In dichloromethane at 0 - 20℃; Inert atmosphere;	45.2 Step 2: Synthesis of 4-hydroxy-2,2,3,3-tetramethylbutyl 2,6-dimethylbenzoate (45b) To a stirred solution of 2,2,3,3-tetramethylbutane-1,4-diol (45a) (0.71 g, 4.9 mmol) in DCM (15 mL) at 0° C. under an atmosphere of argon was added 2,6-dimethylbenzoyl chloride (0.2 mL, 1.6 mmol), pyridine (0.26 mL, 3.2 mmol) and N,N-4-dimethylaminopyridine (0.04 g, 0.3 mmol). The mixture was allowed to warm to room temperature and stirred at room temperature overnight. The mixture was cooled to 0° C. and the reaction was quenched by the addition of 1N HCl (15 mL), then extracted with DCM (twice). The combined organic layers were washed with sat. sodium bicarbonate and brine, then dried (Na2SO4), and concentrated under vacuum. The residue was purified by column chromatography on silica gel using EtOAc/hexanes (0:1 to 3:2) as eluent to give the product ( 45b) as an oil (266 mg). 1H NMR (300 MHz, CDCl3): δ 7.18 (t, J=8.4 Hz, 1H), 7.02 (d, J=6.9 Hz, 2H), 4.25 (s, 2H), 3.51 (s, 2H), 2.31 (s, 6H), 0.98 (s, 6H), 0.93 (s, 6H).
266 mg	With pyridine; dmap In dichloromethane at 0 - 20℃; Inert atmosphere;	70.2 Step 2: Synthesis of 4-hydroxy-2,2,3,3-tetramethylbutyl 2,6-dimethylbenzoate (70b) To a stirred solution of 442 2,2,3,3-tetramethylbutane-1,4-diol (70a) (0.71 g, 4.9 mmol) in 188 DCM (15 mL) at 0° C. under an atmosphere of argon was added 419 2,6-dimethylbenzoyl chloride (0.2 mL, 1.6 mmol), 17 pyridine (0.26 mL, 3.2 mmol) and 18 N,N-4-dimethylaminopyridine (0.04 g, 0.3 mmol). The mixture was allowed to warm to room temperature and stirred at room temperature overnight. The mixture was cooled to 0° C. and the reaction was quenched by the addition of 1N 20 HCl (15 mL), then extracted with DCM (twice). The combined organic layers were washed with sat. sodium bicarbonate and brine, then dried (Na2SO4), and concentrated under vacuum. The residue was purified by column chromatography on silica gel using 21 EtOAc/hexanes (0:1 to 3:2) as eluent to give the product (445 70b) as an oil (266 mg). 1H-NMR (300 MHz, CDCl3): δ 7.18 (t, J=8.4 Hz, 1H), 7.02 (d, J=6.9 Hz, 2H), 4.25 (s, 2H), 3.51 (s, 2H), 2.31 (s, 6H), 0.98 (s, 6H), 0.93 (s, 6H).
266 mg	With pyridine; dmap In dichloromethane at 0 - 20℃;	45.2 Step 2: Synthesis of 4-hydroxy-2,2,3,3-tetramethylbutyl 2,6-dimethylbenzoate (45b) To a stirred solution of 2,2,3,3-tetramethylbutane-1,4-diol (45a) (0.71 g, 4.9 mmol) in DCM (15 mL) at 0° C. under an atmosphere of argon was added 2,6-dimethylbenzoyl chloride (0.2 mL, 1.6 mmol), pyridine (0.26 mL, 3.2 mmol) and N,N-4-dimethylaminopyridine (0.04 g, 0.3 mmol). The mixture was allowed to warm to room temperature and stirred at room temperature overnight. The mixture was cooled to 0° C. and the reaction was quenched by the addition of 1N HCl (15 mL), then extracted with DCM (twice). The combined organic layers were washed with sat. sodium bicarbonate and brine, then dried (Na2SO4), and concentrated under vacuum. The residue was purified by column chromatography on silica gel using EtOAc/hexanes (0:1 to 3:2) as eluent to give the product (45b) as an oil (266 mg). 1H-NMR (300 MHz, CDCl3): δ 7.18 (t, J=8.4 Hz, 1H), 7.02 (d, J=6.9 Hz, 2H), 4.25 (s, 2H), 3.51 (s, 2H), 2.31 (s, 6H), 0.98 (s, 6H), 0.93 (s, 6H).

Reference： [1]Current Patent Assignee: ARIXA PHARMACEUTICALS INC - US10085999, 2018, B1 Location in patent: Page/Page column 165
[2]Current Patent Assignee: ARIXA PHARMACEUTICALS INC - US2019/100516, 2019, A1 Location in patent: Paragraph 1269; 1270
[3]Current Patent Assignee: ARIXA PHARMACEUTICALS INC - US2020/102307, 2020, A1 Location in patent: Paragraph 1546; 1549-1550

54
[ 32812-23-0 ]
[ 21900-37-8 ]
4-hydroxy-3,3-dimethylbutyl 2,6-dimethylbenzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
28%	With pyridine; dmap In dichloromethane at 0 - 20℃; Inert atmosphere;	62.1 Step 1: Synthesis of 4-hydroxy-3,3-dimethylbutyl 2,6-dimethylbenzoate (62a) To a stirred solution of 2,2-dimethylbutane-1,4-diol (0.84 g, 7.1 mmol) in DCM (9 mL) at ca. 0° C. (ice bath) under an argon atmosphere, was added 2,6-dimethylbenzoyl chloride (1.0 g, 5.9 mmol), pyridine (0.96 mL, 11.9 mmol), and N,N-4-dimethylaminopyridine (catalytic amount). The reaction mixture was allowed to gradually warm to room temperature and the mixture was stirred overnight. The mixture was quenched by the addition of 1N HCl (50 mL). The organic and aqueous layers were partitioned and the aqueous layer was extracted with DCM (twice). The combined organic layers were washed with saturated NaHCO3, and then dried (Na2SO4), and concentrated under vacuum. The residue was purified by column chromatography on silica gel using EtOAc/hexanes (0:1 to 3:7) as eluent to give the desired product (62a) (0.42 g, 28%). 1H NMR (300 MHz, CDCl3): δ 7.18 (t, J=7.6 Hz, 1H), 7.04-7.01 (m, 2H), 4.41 (t, J=7.6 Hz, 2H), 3.37 (s, 2H), 2.31 (s, 6H), 1.76 (t, J=7.5 Hz, 2H), 0.97 (s, 6H).
28%	With pyridine; dmap In dichloromethane at 0 - 20℃; Inert atmosphere;	86.1 Step 1: Synthesis of 4-hydroxy-3,3-dimethylbutyl 2,6-dimethylbenzoate (86a) To a stirred solution of 578 2,2-dimethylbutane-1,4-iol (47a) (0.84 g, 7.1 mmol) in 188 DCM (9 mL) at ca. 0° C. (ice bath) under an argon atmosphere, was added 419 2,6-dimethylbenzoyl chloride (1.0 g, 5.9 mmol), 17 pyridine (0.96 mL, 11.9 mmol), and 18 N,N-4-dimethylaminopyridine (catalytic amount). The reaction mixture was allowed to gradually warm to room temperature and the mixture was stirred overnight. The mixture was quenched by the addition of 1N 20 HCl (50 mL). The organic and aqueous layers were partitioned and the aqueous layer was extracted with DCM (twice). The combined organic layers were washed with saturated NaHCO3, and then dried (Na2SO4), and concentrated under vacuum. The residue was purified by column chromatography on silica gel using 21 EtOAc/hexanes (0:1 to 3:7) as eluent to give the desired 579 product (86a) (0.42 g, 28%). 1H-NMR (300 MHz, CDCl3): δ 7.18 (t, J=7.6 Hz, 1H), 7.04-7.01 (m, 2H), 4.41 (t, J=7.6 Hz, 2H), 3.37 (s, 2H), 2.31 (s, 6H), 1.76 (t, J=7.5 Hz, 2H), 0.97 (s, 6H).
28%	With pyridine; dmap In dichloromethane at 0 - 20℃; Inert atmosphere;	61.1 Step 1: Synthesis of 4-hydroxy-3,3-dimethylbutyl 2,6-dimethylbenzoate (61a) To a stirred solution of 2,2-dimethylbutane-1,4-diol (0.84 g, 7.1 mmol) in DCM (9 mL) at ca. 0° C. (ice bath) under an argon atmosphere, was added 2,6-dimethylbenzoyl chloride (1.0 g, 5.9 mmol), pyridine (0.96 mL, 11.9 mmol), and N,N-4-dimethylaminopyridine (catalytic amount). The reaction mixture was allowed to gradually warm to room temperature and the mixture was stirred overnight. The mixture was quenched by the addition of 1N HCl (50 mL). The organic and aqueous layers were partitioned and the aqueous layer was extracted with DCM (twice). The combined organic layers were washed with saturated NaHCO3, and then dried (Na2SO4), and concentrated under vacuum. The residue was purified by column chromatography on silica gel using EtOAc/hexanes (0:1 to 3:7) as eluent to give the desired product (61a) (0.42 g, 28%).

Reference： [1]Current Patent Assignee: ARIXA PHARMACEUTICALS INC - US10085999, 2018, B1 Location in patent: Page/Page column 196
[2]Current Patent Assignee: ARIXA PHARMACEUTICALS INC - US2019/100516, 2019, A1 Location in patent: Paragraph 1357; 1358
[3]Current Patent Assignee: ARIXA PHARMACEUTICALS INC - US2020/102307, 2020, A1 Location in patent: Paragraph 1636-1638

55
[ 3121-82-2 ]
[ 21900-37-8 ]
5-hydroxy-4,4-dimethylpentyl 2,6-dimethylbenzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
25%	With pyridine at 0 - 20℃; for 3h;	67.1 Step 1: Synthesis of 5-hydroxy-3,3-dimethylpentyl 2,6-dimethylbenzoate (67a) To a stirred solution of 2,2-dimethylpentane-1,5-diol (1.1 g, 8.3 mmol) in pyridine (8.3 mL) at 0° C. under an argon atmosphere was added 2,6-dimethylbenzoyl chloride in one portion. The reaction mixture was allowed to warm to room temperature for 3 h. The reaction was concentrated to dryness and EtOAc was added. The mixture was filtered and the filtrate was concentrated under vacuum. The residue was purified by column chromatography on silica gel using EtOAc/hexanes (0:1 to 1:4) as eluent to give the product (67a) (0.44 g, 25%) as an oil. 1H NMR (300 MHz, CDCl3): δ 7.18 (t, J=7.7 Hz, 1H), 7.03 (d, J=7.5 Hz, 2H), 4.32 (t, J=6.3 Hz, 2H), 3.34 (s, 2H), 2.32 (s, 6H), 1.78-1.68 (m, 2H), 1.40-1.34 (m, 2H), 0.90 (s, 6H).

Reference： [1]Current Patent Assignee: ARIXA PHARMACEUTICALS INC - US10085999, 2018, B1 Location in patent: Page/Page column 204

56
[ 21900-37-8 ]
2,6-dimethyl-benzoic acid hydrazide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
43 g	With potassium carbonate; hydrazine hydrate; sodium hydroxide In acetic acid butyl ester; water at 15 - 40℃; for 1h;	1.3 In another flask, hydrazine (16.6 g, 0.333 mol) was taken in mixture of 25% aqueous NaOH (400 mL), 10% K2CO3 solution (60 mL) and n-butyl acetate (400 mL). The mixture was cooled to 15° C. and the acid chloride prepare above was slowly added. The resultant mixture was stirred at 40° C. for an hour. After completion of the reaction, the organic layer separated and concentrated. The crude product (55 g) was triturated with ethyl acetate and filtered to obtain 43 g of intermediate 6. 1H-NMR (400 MHz, DMSO-d6): δ [ppm] 2.19 (s, 6H), 4.43 (s, br, 2H), 7.01-7.04 (m, 2H), 7.13-7.17 (m, 1H), 9.31 (s, br, 1H).

Reference： [1]Current Patent Assignee: SUMITOMO CHEMICAL COMPANY LIMITED; Sumitomo Chemical (w/o Dongwoo Fine-Chem) - US2019/51846, 2019, A1 Location in patent: Paragraph 0149; 0170; 0175-0179; 0180

57
[ 53120-74-4 ]
[ 21900-37-8 ]
5-hydroxy-3,3-dimethylpentyl 2,6-dimethylbenzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
25%	With pyridine at 0 - 20℃; for 3h; Inert atmosphere;	91.1 Step 1: Synthesis of 5-hydroxy-3,3-dimethylpentyl 2,6-dimethylbenzoate (91a) To a stirred solution of 597 2,2-dimethylpentane-1,5-diol (1.1 g, 8.3 mmol) in 17 pyridine (8.3 mL) at 0° C. under an argon atmosphere was added 419 2,6-dimethylbenzoyl chloride in one portion. The reaction mixture was allowed to warm to room temperature for 3 h. The reaction was concentrated to dryness and 21 EtOAc was added. The mixture was filtered and the filtrate was concentrated under vacuum. The residue was purified by column chromatography on silica gel using EtOAc/hexanes (0:1 to 1:4) as eluent to give the 611 product (91a) (0.44 g, 25%) as an oil. 1H-NMR (300 MHz, CDCl3): δ 7.18 (t, J=7.7 Hz, 1H), 7.03 (d, J=7.5 Hz, 2H), 4.32 (t, J=6.3 Hz, 2H), 3.34 (s, 2H), 2.32 (s, 6H), 1.78-1.68 (m, 2H), 1.40-1.34 (m, 2H), 0.90 (s, 6H).

Reference： [1]Current Patent Assignee: ARIXA PHARMACEUTICALS INC - US2019/100516, 2019, A1 Location in patent: Paragraph 1382; 1383

58
2,2,4,4-tetramethylpentane-1,5-diol [ No CAS ]
[ 21900-37-8 ]
5-hydroxy-2,2,4,4-tetramethylpentyl benzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
53%	With pyridine In dichloromethane at 0 - 20℃;	41.1 Step 1: Synthesis of 5-hydroxy-2,2,4,4-tetramethylpentyl 2,6-dimethylbenzoate (41a) To a stirred solution of 2,2,4,4-tetramethylpentane-1,5-diol (39c) (0.48 g, 3.0 mmol) and pyridine (0.24 mL, 3.0 mmol) in DCM (20 mL) was added 2,6-dimethylbenzoyl chloride (0.45 mL, 3.0 mmol) dropwise over the course of 30 min at 0° C. (ice bath) under an atmosphere of argon. The reaction mixture was stirred overnight at room temperature. The mixture was diluted with H2O (20 mL), and the layers were separated. The aqueous layer was extracted with DCM (2×20 mL), and the combined organic layers were washed with brine (20 mL), dried (Na2SO4), and concentrated under vacuum. The residue was purified by column chromatography on silica gel using EtOAc/hexanes (5:95 to 1:1) as eluent to give the product (41a) (462 mg, 53%) as an oil. 1H-NMR (300 MHz, CDCl3): δ 7.22-7.17 (m, 1H), 7.04 (d, J=7.5 Hz, 2H), 4.10 (s, 2H), 3.32 (s, 2H), 2.33 (s, 6H), 1.41 (s, 2H), 1.10 (s, 6H), 1.00 (s, 6H).

Reference： [1]Current Patent Assignee: ARIXA PHARMACEUTICALS INC - US2020/102307, 2020, A1 Location in patent: Paragraph 1529-1531

59
2-methoxy-N-(3-(((3R,4R)-4-methoxypyrrolidin-3-yl)oxy)phenyl)benzenesulfonamide hydrochloride [ No CAS ]
[ 21900-37-8 ]
N-(3-(((3R,4R)-1-(2,6-dimethylbenzoyl)-4-methoxypyrrolidin-3-yl)oxy)phenyl)-2-methoxybenzenesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
145 mg	With triethylamine In N,N-dimethyl-formamide at 20℃; for 3h;	74.D D) N-(3-(((3R,4R)-1-(2,6-dimethylbenzoyl)-4-methoxypyrrolidin-3-yl)oxy)phenyl)-2-methoxybenzenesulfonamide To a mixture of 2-methoxy-N-(3-(((3R,4R)-4-methoxypyrrolidin-3-yl)oxy)phenyl)benzenesulfonamide hydrochloride (120 mg), TEA (147 mg) and DMF (4 ml) was added 2,6-dimethylbenzoyl chloride (53.8 mg). The mixture was stirred at room temperature for 3 hr. The mixture was poured into water, and extracted with ethyl acetate. The organic layer was separated, washed with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (145 mg). 1H NMR (300 MHz, DMSO-d6) δ 1.87-2.19 (6H, m), 2.84-3.02 (1H, m), 3.15-3.41 (4H, m), 3.60-3.74 (2H, m), 3.79-4.00 (4H, m), 4.65-4.91 (1H, m), 6.46-6.80 (3H, m), 6.91-7.29 (6H, m), 7.48-7.63 (1H, m), 7.67-7.84 (1H, m), 9.94-10.13 (1H, m).

Reference： [1]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - US2020/392149, 2020, A1 Location in patent: Paragraph 0708; 0714-0715

60
[ 614-45-9 ]
[ 21900-37-8 ]
[ 155249-15-3 ]

Yield	Reaction Conditions	Operation in experiment
4.03 g	Stage #1: tert-Butyl peroxybenzoate With sodium hydride In tetrahydrofuran; decane; mineral oil at -10℃; for 0.333333h; Stage #2: 2,6-dimethylbenzoyl chloride In tetrahydrofuran; decane; mineral oil at -10℃; for 0.333333h;	12 To a stirred solution of TBHP (5.5 M in decane) (7.3 mL, 40 mmol, 2.0 eq.) in anhydrous THF (75 mL) was added NaH (60% dispersion in mineral oil) (1.59 g, 40 mmol, 2.0 eq.) and the solution was stirred for 20 min at -10° C. (salt water/ice). After such time, the crude acid chloride obtained in the previous step was added dropwise in 5.0 mL anhydrous THF and the solution was stirred for 20 min at -10° C. After such time, the reaction mixture was quenched with NaHCO3 (50 mL) and stirred until effervescence ceased. The layers were separated and the organic layer was washed with brine (1×30 mL), dried over Na2SO4, filtered and concentrated in vacuo. The crude mixture was purified by flash column chromatography on silica (10:90 EtOAc:Hexanes) to afford the title compound ( 51) contaminated with decane. To remove decane, the residue obtained was dissolved in 50 mL CH3CN and washed with Hexanes (2×15 mL) affording pure perester (51) (4.03 g, 18.14 mmol, 91% over 2 steps) as a colorless oil. TLC: Rf=0.50 (10:90 EtOAc:Hexanes; UV, p-anisaldehyde). 1H NMR (500 MHz, CDCl3): δ 7.23 (t, J=7.62 Hz, 1H), 7.05 (d, J=7.63 Hz, 2H), 2.37 (s, 6H), 1.40 (s, 9H). 13C NMR (126 MHz, CDCl3): δ 167.4, 136.2 (2C), 130.7, 130.3, 127.7 (2C), 83.7, 26.6 (3C), 19.8 (2C). HRMS-ESI (m/z): [M+Na]+ calculated for [C13H18O3Na]+: 245.1148, found: 245.1143.

Reference： [1]Current Patent Assignee: UNIVERSITY SYSTEM OF GEORGIA - US2021/363098, 2021, A1 Location in patent: Page/Page column 0295; 0304; 0306

61
[ 21900-37-8 ]
[ 121-88-0 ]
(2-amino-5-nitrophenyl) 2,6-dimethylbenzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine In dichloromethane at 20℃;	2-(2,6-Dimethylphenyl)-6-nitro-1,3-benzoxazole (5) To a solution of 2-amino-5-nitrophenol (4) (0.57 g, 3.7 mmol) and triethylamine (0.61 mL, 4.4 mmol) inCH2Cl2 (10 mL) was added crude 2,6-dimethylbenzoyl chloride (0.62 g). The mixture was stirred at rtovernight. Water was added to the reaction solution, followed by partitioning using AcOEt. The organicphase was washed with brine, dried over sodium sulfate, and filtered. Then, the solvent was distilledunder reduced pressure to give the crude title compound. The obtained residue was partially purified bysilica gel column chromatography (AcOEt: hexane = 10:90 to 45:55) to give crude(2-amino-5-nitro-phenyl) 2,6-dimethylbenzoate (0.63 g), which was used in the next reaction withoutfurther purification

Reference： [1]Akiu, Mayuko; Asano, Daigo; Hasegawa, Tomoko; Honda, Tomohiro; Ishizaka, Tomomichi; Nakamura, Tsuyoshi; Pinkerton, Anthony B.; Sogawa, Yoshitaka; Terayama, Koji; Tsuji, Takashi; Yokoyama, Mika [Heterocycles, 2021, vol. 104, # 1, p. 94 - 122]

62
4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoylhydrazine [ No CAS ]
[ 21900-37-8 ]
4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N'-(2,6-dimethylbenzoyl)-2-methylbenzohydrazide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
0.9 g	With triethylamine In dichloromethane at 20℃;	27.3 (3)4-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl)-N'-(2,6-dimethylbenzoyl)-2-methylbenzoylhydrazide: The 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole-3-yl)-2-methylbenzoylhydrazide (0.209g, 0.5mmol), triethylamine (0.066g, 0.65mmol) was added to a 100mL three-mouth round-bottom flask, 10mL of dichloromethane was added, 2,6-dimethylbenzoyl chloride (0.109g, 0.65mmol) was added dropwise, and the reaction at room temperature was 8 to 12h. After the end of the reaction, the reaction mixture was desolubled under reduced pressure, the silica gel was mixed, and the chromatography column was separated to obtain a white solid of 0.90g.

Reference： [1]Current Patent Assignee: GUIZHOU UNIVERSITY - CN114380762, 2022, A Location in patent: Paragraph 0217-0221

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

CAS No. :	21900-37-8	MDL No. :	MFCD00052854
Formula :	C₉H₉ClO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	CFLAYISSADVCJH-UHFFFAOYSA-N
M.W :	168.62	Pubchem ID :	89096
Synonyms :

Num. heavy atoms :	11
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.22
Num. rotatable bonds :	1
Num. H-bond acceptors :	1.0
Num. H-bond donors :	0.0
Molar Refractivity :	46.56
TPSA :	17.07 Å²

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.06 cm/s

[ CAS No. 21900-37-8 ] {[proInfo.proName]}

Quality Control of [ 21900-37-8 ]

Related Doc. of [ 21900-37-8 ]

Product Details of [ 21900-37-8 ]

Calculated chemistry of [ 21900-37-8 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 21900-37-8 ]

Application In Synthesis of [ 21900-37-8 ]

[ 21900-37-8 ] Synthesis Path-Upstream 1~3

[ 21900-37-8 ] Synthesis Path-Downstream 1~62

Related Functional Groups of
[ 21900-37-8 ]

Aryls

Chlorides

Acyl Chlorides

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Log Po/w (iLOGP) :	2.19
Log Po/w (XLOGP3) :	3.19
Log Po/w (WLOGP) :	2.68
Log Po/w (MLOGP) :	2.67
Log Po/w (SILICOS-IT) :	3.26
Consensus Log Po/w :	2.8

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Log S (ESOL) :	-3.23
Solubility :	0.0987 mg/ml ; 0.000585 mol/l
Class :	Soluble
Log S (Ali) :	-3.22
Solubility :	0.102 mg/ml ; 0.000603 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.73
Solubility :	0.0314 mg/ml ; 0.000186 mol/l
Class :	Soluble

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.07

Signal Word:	Danger	Class:	8
Precautionary Statements:	P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P321-P363-P405-P501	UN#:	3265
Hazard Statements:	H314	Packing Group:	Ⅲ
GHS Pictogram:

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Code	Phrase
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P321
P322
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P342	If experiencing respiratory symptoms:
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P353	Rinse skin with water/shower.
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P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
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P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
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Disposal
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P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling