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Chemical Structure| 21873-50-7 Chemical Structure| 21873-50-7

Structure of 21873-50-7

Chemical Structure| 21873-50-7

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Product Details of [ 21873-50-7 ]

CAS No. :21873-50-7
Formula : C9H6FNO
M.W : 163.15
SMILES Code : O=C1C=CNC2=C1C=C(F)C=C2
MDL No. :MFCD00269610

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Application In Synthesis of [ 21873-50-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 21873-50-7 ]
  • Downstream synthetic route of [ 21873-50-7 ]

[ 21873-50-7 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 21873-50-7 ]
  • [ 661463-17-8 ]
YieldReaction ConditionsOperation in experiment
76% With phosphorus tribromide In DMF (N,N-dimethyl-formamide); water at 0 - 20℃; for 1.08333 h; To a solution of (10b) (11.3 g, 69.3 mmol) in DMF (350 ml) was added dropwisephosphorous tribromide (7.1 ml, 76.3 mmol) over five minutes (slightly exothermic). The reaction was allowed to cool to room temperature and was then diluted with ice water and stirred 1 hour then diluted with additional water. The product was filtered off, washed with water and dried in vacuo to afford the product as a white solid (12.0 g, 76percent). MS (+ve ion electrospray) m/z 226 (MH+).
References: [1] Patent: WO2004/14361, 2004, A1, . Location in patent: Page/Page column 41.
 

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