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Chemical Structure| 21691-53-2 Chemical Structure| 21691-53-2

Structure of 21691-53-2

Chemical Structure| 21691-53-2

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Product Details of [ 21691-53-2 ]

CAS No. :21691-53-2
Formula : C10H21NO2
M.W : 187.28
SMILES Code : CC(C)C[C@H](N)C(OC(C)(C)C)=O
MDL No. :MFCD00038311

Safety of [ 21691-53-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 21691-53-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 21691-53-2 ]

[ 21691-53-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 21691-53-2 ]
  • [ 150188-64-0 ]
  • [ 1448616-12-3 ]
YieldReaction ConditionsOperation in experiment
62% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 20℃; for 2.08333h; General procedure: To a solution of the commercially available L-leucine tert-butyl ester 18a (0.200 g, 0.89 mmol) in DMF (15 mL) was added an isovaleric acid (0.100 g, 0.98 mmol), HOBt·H2O (0.151 g, 0.98 mmol),and EDC·HCl (0.189 g, 0.98 mmol). The resulting solution wascooled to 0 C under ice bath conditions, and TEA was then added dropwise. After 5 min, the ice bath was removed and the mixture was allowed to stir for 2 h at ambient temperature. DMF was removed under high vacuum, and the resulting residue was dissolved in EtOAc (30 mL). The organic layer was washed with 5% citric acid (20 mL x 2), 5% NaHCO3 (20 mL x 2), and brine (20 mL).The solution was dried over Na2SO4, filtered, and evaporated under reduced pressure to give compound 19a. The resulting crude compound was purified by silica gel column chromatography using hexane-EtOAc as eluents.
 

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