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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 21577-50-4 Chemical Structure| 21577-50-4

Structure of 21577-50-4

Chemical Structure| 21577-50-4

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Product Details of [ 21577-50-4 ]

CAS No. :21577-50-4
Formula : C4H2Br2O3
M.W : 257.86
SMILES Code : O=C(O)C(Br)=C(Br)C=O
MDL No. :MFCD00063745

Safety of [ 21577-50-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P501-P260-P264-P280-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P405
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 21577-50-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 21577-50-4 ]

[ 21577-50-4 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 21577-50-4 ]
  • [ 463-52-5 ]
  • [ 64224-60-8 ]
  • 2
  • [ 21577-50-4 ]
  • [ 57297-29-7 ]
  • [ 304902-95-2 ]
YieldReaction ConditionsOperation in experiment
72% NaH (60percent purity, 41 .9 g) is added in portions to EtOH (800 ml.) at 0 °C. The resulting mixture is warmed to ambient temperature and the cyclopropanecarboxamidine hydrochlorid (93.5 g,) is added in portions. The reaction is warmed to 50 °C and maintained at this temperature for 0.5 h and then cooled to ambient temperature before mucobromic acid (100 g) is added in EtOH while keeping the internal temperature below 55 °C. The mixture is allowed to cool to ambient temperature and stirred for additional 16 h. All solid components are removed by filtration and the resulting solution is concentrated under reduced pressure. Aq. HCI (1 mol/L) is added, the aqueous phase is washed with EtOAc (3x), the combined organic extracts are dried over MgS04 and the solid parts removed by filtration. The residue is concentrated under reduced pressure and the resulting solid titrated with (Rho Omicron. The solids are collected by filtration and dried yielding the title compound (68.0 g, yield 72 percent) as a colorless solid. 1 H NMR (400 MHz, CDCI3): delta = 8.91 (s, 1 H), 2.38 - 2.26 (m, 1 H), 1.34 - 1 .14 (m, 4H) ppm; MS (ESI) m/z 244.9 [M + H+].
  • 3
  • [ 21577-50-4 ]
  • [ 1820-80-0 ]
  • [ 63572-73-6 ]
 

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Technical Information

• Alkyl Halide Occurrence • Arndt-Eistert Homologation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Chaykovsky Reaction • Corey-Fuchs Reaction • Fischer Indole Synthesis • General Reactivity • Grignard Reaction • Hantzsch Dihydropyridine Synthesis • Heat of Combustion • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hunsdiecker-Borodin Reaction • Hydride Reductions • Julia-Kocienski Olefination • Kinetics of Alkyl Halides • Knoevenagel Condensation • Kumada Cross-Coupling Reaction • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mukaiyama Aldol Reaction • Nozaki-Hiyama-Kishi Reaction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Preparation of Carboxylic Acids • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Carboxylic Acids • Reactions of Dihalides • Reformatsky Reaction • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stetter Reaction • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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