Home Cart Sign in  
Chemical Structure| 214767-15-4 Chemical Structure| 214767-15-4

Structure of 214767-15-4

Chemical Structure| 214767-15-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 214767-15-4 ]

CAS No. :214767-15-4
Formula : C4H6N2O3
M.W : 130.10
SMILES Code : O=C([C@@H](CN1)NC1=O)O
MDL No. :MFCD00272205
InChI Key :KZKRPYCBSZIQKN-UWTATZPHSA-N
Pubchem ID :7003745

Safety of [ 214767-15-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 214767-15-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 214767-15-4 ]

[ 214767-15-4 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 634614-25-8 ]
  • [ 214767-15-4 ]
YieldReaction ConditionsOperation in experiment
565 mg With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20.0℃; under 760.051 Torr; for 24.0h; Under nitrogen atmosphere, to a solution of (R)-2-oxoimidazolidine-1,5-dicarboxylic acid 1-benzyl ester (1.61 g) in methanol/tetrahydrofuran (4/1, 20 ml) was added 10 wt % palladium on carbon (161 mg) at room temperature, and the mixture was stirred for 24 hours under one atmosphere of hydrogen. Under nitrogen atmosphere, palladium on carbon in this reaction solution was filtered off through Celite, and the filtrate was concentrated under reduced pressure. To the resulting residue were added diisopropyl ether and n-hexane, and the mixture was stirred. A solid was collected from this suspension by filtration, and dried under reduced pressure to give the titled compound (565 mg).
  • 2
  • [ 1426408-84-5 ]
  • [ 214767-15-4 ]
  • [ 1426404-47-8 ]
YieldReaction ConditionsOperation in experiment
56 mg With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 20.0℃; for 3.0h; To a solution of 1-(4-fluorophenyl)-5-[3-fluoro-5-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-1H-pyrazol-3-ylamine (about 0.277 mmol) prepared in the previous step in chloroform (1 ml) were sequentially added <strong>[214767-15-4](R)-2-oxoimidazolidine-4-carboxylic acid</strong> (40 mg) and WSC.HCl (64 mg) at room temperature, and the mixture was stirred for 3 hours. This reaction mixture was purified by silica gel thin-layer chromatography (eluent: chloroform/methanol=10/1). To the resulting solid were added water and a small amount of methanol, and the mixture was stirred. A solid was collected from this suspension by filtration and was dried under reduced pressure to give the titled compound (56 mg). 1H-NMR (DMSO-D6) δ: 1.20 (d, 3H, J=6.0 Hz), 3.35 (dd, 1H, J=8.6, 6.2 Hz), 3.58 (dd, 1H, J=9.3, 8.6 Hz), 4.12 (tq, 1H, J=9.7, 6.0 Hz), 4.31 (dd, 1H, J=9.3, 6.2 Hz), 4.60 (d, 1H, J=12.5 Hz), 4.63 (d, 1H, J=12.5 Hz), 6.33 (s, 1H), 6.59 (s, 1H), 6.98 (s, 1H), 7.02-7.07 (m, 2H), 7.18 (d, 1H, J=9.6 Hz), 7.23-7.35 (m, 4H), 10.72 (s, 1H).
  • 3
  • [ 214767-15-4 ]
  • [ 1426408-95-8 ]
  • (R)-2-oxoimidazolidine-4-carboxylic acid [5-(3-butylphenyl)-1-phenyl-1H-pyrazol-3-yl]amide [ No CAS ]
YieldReaction ConditionsOperation in experiment
12 mg With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20.0℃; for 2.0h; To a solution of 5-(3-butylphenyl)-1-phenyl-1H-pyrazol-3-ylamine (40 mg) in N,N-dimethylformamide (0.4 ml) were sequentially added <strong>[214767-15-4](R)-2-oxoimidazolidine-4-carboxylic acid</strong> (21 mg) prepared by the same procedures as Preparation 20, HATU (63 mg), diisopropylethylamine (29 μL) at room temperature, and the mixture was stirred for 2 hours. To this reaction mixture was added water, and the mixture was extracted with ethyl acetate. The resulting organic layer was washed with water and a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The resulting residue was purified by silica gel thin-layer chromatography (eluent: n-hexane/acetone=1/5). To the resulting solid was added diisopropyl ether, and the mixture was stirred. A solid was collected from this suspension by filtration, and was dried under reduced pressure to give the titled compound (12 mg). 1H-NMR (DMSO-D6) δ: 0.82 (t, 3H, J=7.4 Hz), 1.15 (tq, 2H, J=7.4 Hz, 7.4 Hz), 1.39 (tt, 2H, J=7.4 Hz, 7.4 Hz), 2.48 (t, 2H, J=7.4 Hz), 3.36 (dd, 1H, J=9.2 Hz, 5.6 Hz), 3.59 (dd, 1H, J=9.2 Hz, 9.2 Hz), 4.32 (dd, 1H, J=9.2 Hz, 5.6 Hz), 6.33 (s, 1H), 6.60 (s, 1H), 6.90 (s, 1H), 6.98 (s, 1H), 7.09 (d, 1H, J=7.6 Hz), 7.17 (d, 1H, J=7.6 Hz), 7.20-7.30 (m, 3H), 7.32-7.43 (m, 3H), 10.70 (s, 1H).
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 214767-15-4 ]

Amides

Chemical Structure| 21277-16-7

A593440 [21277-16-7]

2-Oxoimidazolidine-4-carboxylic Acid

Similarity: 1.00

Chemical Structure| 41371-53-3

A429000 [41371-53-3]

(S)-2-Oxoimidazolidine-4-carboxylic acid

Similarity: 1.00

Chemical Structure| 917598-39-1

A726054 [917598-39-1]

1,3-Dimethyl-2-oxoimidazolidine-4-carboxylic acid

Similarity: 0.91

Chemical Structure| 157001-86-0

A812483 [157001-86-0]

(S)-Methyl 2-oxoimidazolidine-4-carboxylate

Similarity: 0.88

Chemical Structure| 5624-16-8

A342942 [5624-16-8]

2,5-Dioxoimidazolidine-4-carboxylic acid

Similarity: 0.84

Carboxylic Acids

Chemical Structure| 21277-16-7

A593440 [21277-16-7]

2-Oxoimidazolidine-4-carboxylic Acid

Similarity: 1.00

Chemical Structure| 41371-53-3

A429000 [41371-53-3]

(S)-2-Oxoimidazolidine-4-carboxylic acid

Similarity: 1.00

Chemical Structure| 917598-39-1

A726054 [917598-39-1]

1,3-Dimethyl-2-oxoimidazolidine-4-carboxylic acid

Similarity: 0.91

Chemical Structure| 5624-16-8

A342942 [5624-16-8]

2,5-Dioxoimidazolidine-4-carboxylic acid

Similarity: 0.84

Chemical Structure| 56099-64-0

A650949 [56099-64-0]

(S)-2-(3-Methylureido)propanoic acid

Similarity: 0.81

Related Parent Nucleus of
[ 214767-15-4 ]

Imidazolidines

Chemical Structure| 21277-16-7

A593440 [21277-16-7]

2-Oxoimidazolidine-4-carboxylic Acid

Similarity: 1.00

Chemical Structure| 41371-53-3

A429000 [41371-53-3]

(S)-2-Oxoimidazolidine-4-carboxylic acid

Similarity: 1.00

Chemical Structure| 917598-39-1

A726054 [917598-39-1]

1,3-Dimethyl-2-oxoimidazolidine-4-carboxylic acid

Similarity: 0.91

Chemical Structure| 157001-86-0

A812483 [157001-86-0]

(S)-Methyl 2-oxoimidazolidine-4-carboxylate

Similarity: 0.88

Chemical Structure| 5624-16-8

A342942 [5624-16-8]

2,5-Dioxoimidazolidine-4-carboxylic acid

Similarity: 0.84