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Chemical Structure| 214707-02-5 Chemical Structure| 214707-02-5

Structure of 214707-02-5

Chemical Structure| 214707-02-5

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Product Details of [ 214707-02-5 ]

CAS No. :214707-02-5
Formula : C11H3Cl2F3N4
M.W : 319.07
SMILES Code : FC1=C(C2=C(Cl)N3C(N=C2Cl)=NC=N3)C(F)=CC(F)=C1

Safety of [ 214707-02-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 214707-02-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 214707-02-5 ]

[ 214707-02-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 214707-02-5 ]
  • [ 130596-62-2 ]
  • 5-chloro-7-(4,4-dimethyl-[1,4]azasilinan-1-yl)-6-(2,4,6-trifluoro-phenyl)-[1,2,4]triazolo[1,5-a]pyrimidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate;dmap; In ISOPROPYLAMIDE; at 20℃; for 2h; d) 4,4-dimethyl-[1 ,4]azasilinane hydrochloride (120 mg, 0.7 mmol) is added to a suspension of 5>7-dichloro-6-(2,4,6)-trifluoro-phenyl)-[1 ,2,4]triazolo[1 ,5-a]pyrimidine(190 mg, 0.6 mmol), potassium carbonate anhydrous (200 mg, 1.5 mmol) and catalytic amounts of 4-(dimethylamino)pyridine in 4 ml of N.N-dimethylacetamide. This mixture is stirred 2 h at room temperature, then poured on icewater and extracted with ethyl acetate. The combined organic layer is washed with water and brine, dried over magnesium sulfate and evaporated. The residue is purified by chromatography on silica gel, using ethyl aceate and hexane as eluents, to deliver 100 mg of 5-chloro-7-(4,4-dimethyl-[1 ,4]azasilinan-1-yl)-6-(2,4,6-trifluoro-phenyl)- [1 ,2,4]triazolo[1 ,5-a]pyrimidine (Compound No.l.p.081).
 

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