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Chemical Structure| 2141-54-0 Chemical Structure| 2141-54-0

Structure of 2141-54-0

Chemical Structure| 2141-54-0

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Product Details of [ 2141-54-0 ]

CAS No. :2141-54-0
Formula : C7H12N2
M.W : 124.18
SMILES Code : CCN(/C=C/C#N)CC

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Application In Synthesis of [ 2141-54-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2141-54-0 ]

[ 2141-54-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2141-54-0 ]
  • [ 56367-24-9 ]
  • 2-isopropylpyrazolo[1,5-a]pyrimidin-7-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
56% With acetic acid; In toluene; at 140℃; for 0.166667h;Microwave irradiation; To a stirred solution of <strong>[56367-24-9]5-isopropyl-1H-pyrazol-3-amine</strong> (XXXII; 1.5g; 12 mmol) and 3- (diethylamino)acrylonitrile (II; 2.3g; 18 mmol) in toluene (50 mL) was added acetic acid (16.5mL). The reaction mixture was heated at 140C in a microwave for 10 minutes. The reaction mixture was cooled and concentrated under reduced pressure. The crude mixture was purified by column chromatography using 5% MeOH-DCM to obtain 2-isopropylpyrazolo[1,5- a]pyrimidin-7-amine as a light brown solid (XXXIII; 1 .2g; 56% yield). ‘H NMR (400 MHz,DMSO-d6): ö 7.97-7.96 (d, J = 5.2 Hz, 1H), 7.52 (bs, 2H), 6.18 (s, 1H), 5.98-5.97 (d, J = 5.2Hz, 1H), 3.09-3.02(m, 1H), 1.30-1.28 (d,J 6.8 Hz, 6H). MS (M+1): 177.0.
 

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