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Chemical Structure| 213765-61-8 Chemical Structure| 213765-61-8

Structure of 213765-61-8

Chemical Structure| 213765-61-8

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Product Details of [ 213765-61-8 ]

CAS No. :213765-61-8
Formula : C5H4INO
M.W : 221.00
SMILES Code : OC1=CC(I)=CN=C1
MDL No. :MFCD10574981

Safety of [ 213765-61-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 213765-61-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 213765-61-8 ]

[ 213765-61-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 161511-85-9 ]
  • [ 213765-61-8 ]
  • [ 213765-43-6 ]
YieldReaction ConditionsOperation in experiment
86% With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20℃; for 48h;Inert atmosphere; General Procedure for the Mitsunobu Reaction. To a mixture of the N-Boc protected alcohol (1.0 equiv), the 5-halogen-3-pyridinol (1.0 equiv), and Ph3P (1.3 equiv) in anhydrous THF (0.1 M) was added DEAD (1.3 equiv) dropwise at 0 C under nitrogen atmosphere. After stirring for 2 days at room temperature, the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel using a gradient of hexane-ethyl acetate (10: 1 to 5: 1) as the eluent to give the product in 68%-90% yield. (S)-tert-butyl-2-((5-iodopyridin-3-yloxy)methyl)azetidine-l-carboxylate ((S)-5). Yield: 86' (white solid). 1H NMR (CDC13, 400 MHz): δ 8.43 (d, 1H, J= 1.2 Hz), 8.30 (d, 1H, J= 2.4 Hz), 7.61 (dd, 1H, J = 2.4, 1.6 Hz), 4.50 (m, 1H), 4.32 (m, 1H), 4.12 (dd, J = 10, 2.8 Hz), 3.88 (m, 2H), 2.31 (m, 2H), 1.43 (s, 9H).
 

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