213453-08-8|2-((2-Bromo-2-methylpropanoyl)oxy)ethyl methacrylate| Ambeed

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Quality Control of [ 213453-08-8 ] Purity: 98% (stabilized with TBC) SDS Specification

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Product Details of [ 213453-08-8 ]

CAS No. :	213453-08-8
Formula :	C₁₀H₁₅BrO₄
M.W :	279.13
SMILES Code :	C(OC(=O)C(C)(C)Br)COC(=O)C(=C)C
MDL No. :	MFCD18785732
InChI Key :	QXDYJUSFCUKOQD-UHFFFAOYSA-N
Pubchem ID :	21216988

Safety of [ 213453-08-8 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302
Precautionary Statements:	P264-P270-P301+P312-P330-P501

Application In Synthesis of [ 213453-08-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 213453-08-8 ]

[ 213453-08-8 ] Synthesis Path-Downstream 1~20

1
[ 868-77-9 ]
[ 20769-85-1 ]
[ 213453-08-8 ]

Yield	Reaction Conditions	Operation in experiment
		The 2-(bromoisobutyryloxy)ethyl methacrylate (BIEM, 2b) monomer was synthesized using a modified method following a previous report.4 In a typical run, HEMA (5.0 g, 0.038 mol) and triethylamine (7.8 g, 0.077 mol) were dissolved in dichloromethane (48.9 g, 0.6 mol) in a round-bottomed Schlenk flask under nitrogen. The reaction mixture was stirred at 0 C. and degassed by N2 for 45 min. α-bromoisobutyryl bromide (10.6 g, 0.046 mol) was then added drop-wise over a period of 20 min. After the reaction mixture was stirred for another 6 h at 0 C., the insoluble solids were filtered off. The filtrate was washed three times each with de-ionized water (3×50 mL), 0.5 M NaHCO3 (3×50 mL) and saturated NaCl (3×50 mL) aqueous solutions, respectively. Subsequently, MgSO4 was added to remove trace water and filtered off. The filtrate was evaporated to dryness. The final product, BIEM (2b), was further dried in a vacuum oven and its structure was confirmed by 1H NMR (FIG. 13A).

References: [1]Macromolecules,2015,vol. 48,p. 2118 - 2126.
[2]Journal of the American Chemical Society,2013,vol. 135,p. 11421 - 11424.
[3]Biomacromolecules,2014,vol. 15,p. 2235 - 2245.
[4]Chemical Communications,2021,vol. 57,p. 399 - 402.
[5]Journal of the American Chemical Society,2003,vol. 125,p. 3831 - 3838.
[6]Angewandte Chemie - International Edition,2016,vol. 55,p. 4260 - 4264.
Angew. Chem.,2016,vol. 128,p. 4332 - 4336,5.
[7]Macromolecules,2012,vol. 45,p. 1313 - 1320.
[8]Patent: US2019/231703,2019,A1 .Location in patent: Paragraph 0104.

2
[ 105-16-8 ]
[ 213453-08-8 ]
polymer, M_n 5700 and M_w/M_n 1.88 by GPC, M_n 7900 and M_w/M_n 3.90 by GPC/viscosimetry; monomer(s): 2-(diethylamino)ethyl methacrylate; 2-(2-bromoisobutyryloxy)ethyl methacrylate [ No CAS ]