There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Structure of 2131-55-7
*Storage: {[sel_prStorage]}
*Shipping: {[sel_prShipping]}
The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
4.5
*For Research Use Only !
Change View
Size | Price | VIP Price | US Stock |
Global Stock |
In Stock | ||
{[ item.pr_size ]} |
Inquiry
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.discount_usd) ]} {[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} |
Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]} | Inquiry {[ item.pr_usastock ]} In Stock Inquiry - | {[ item.pr_chinastock ]} {[ item.pr_remark ]} In Stock 1-2 weeks - Inquiry - | Login | - + | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
1-2weeks
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price, item.pr_usd) ]}
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
In Stock
- +
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 2131-55-7 |
Formula : | C7H4ClNS |
M.W : | 169.63 |
SMILES Code : | ClC1=CC=C(N=C=S)C=C1 |
MDL No. : | MFCD00004810 |
InChI Key : | MZZVFXMTZTVUFO-UHFFFAOYSA-N |
Pubchem ID : | 16480 |
GHS Pictogram: |
![]() ![]() ![]() |
Signal Word: | Danger |
Hazard Statements: | H311-H315-H319-H331-H334-H335 |
Precautionary Statements: | P233-P260-P261-P264-P271-P280-P285-P302+P352-P304-P304+P340-P304+P341-P305+P351+P338-P311-P312-P321-P322-P332+P313-P337+P313-P340-P342+P311-P361-P362-P363-P403-P403+P233-P405-P501 |
Class: | 6.1 |
UN#: | 2811 |
Packing Group: | Ⅱ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
20% | In pyridine; at 100.0℃; for 19.0h; | Description 18 (0.98 g, 6.95 mmol) and 4-chlorophenyl isothiocyanate (1.29 g, 7.65 mmol) were stirred in pyridine (5 ml) at 100 C. After 15 h additional 4chlorophenyl isothiocyanate (0.12 g, 0.70 mmol) was added and heating continued for a further 4 h. The reaction was cooled, poured onto ice and the resultant solid, methyl 5-([(4-chlorophenyl)amino]carbonothioyl}amino)-1H-imidazole-4carboxylate, was collected by filtration and dried (0.42 g, 20 %). Without <Desc/Clms Page number 45>purification, the solid was slurried in 1 % aqueous sodium hydroxide solution (10 ml) and heated at 80 C for 2 h. The reaction was cooled and filtered to remove unreacted starting material. The filtrate was acidified to pH 5 using acetic acid, causing a fine white precipitate to form. The solid was collected, rinsed with water and dried to give the title compound as a fine white solid (0. 28 g, 73 %). 1H NMR (360 MHz, DMSO)8 13.72 (2H, brs), 8.18(1H, s), 7.55 (2H, m), 7.30 (2H, m). Mlz (ES+) 279,281 (M+H+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
A mixture of 2-amino-1-(4-fluoro-phenyl)-ethanone hydrochloride (5.0 g, 26.5 mmol), 4-chlorophenyl isothiocyanate (4.49 g, 26.5 mmol) and sodium hydrogencarbonate (3.3 g, 39.7 mmol) in ethanol (100 mL) was heated at 90 C. for 2 hours. The solvent was removed under reduce pressure. The resulting residue was re-suspended in aqueous 1N sodium hydroxide (50 mL) and heated at 100 C. overnight. The hot mixture was filtered, cooled and carefully acidifed with aqueous 6N HCl. The resulting mixture was filtered to give 1-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-1H-imidazole-2-thiol (8.0 g, 26.3 mmol) as a yellow solid after drying. | ||
A mixture of 2-amino-1-(4-fluoro-phenyl)-ethanone hydrochloride (5.0 g, 26.5 mmol), 4-chlorophenyl isothiocyanate (4.49 g, 26.5 mmol) and sodium hydrogencarbonate (3.3 g, 39.7 mmol) in ethanol (100 mL) was heated at 90 C. for 2 hours. The solvent was removed under reduce pressure. The resulting residue was re-suspended in aqueous 1N sodium hydroxide (50 mL) and heated at 100 C. overnight. The hot mixture was filtered, cooled and carefully acidified with aqueous 6N HCl. The resulting mixture was filtered to give 1-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-1H-imidazole-2-thiol (8.0 g, 26.3 mmol) as a yellow solid after drying. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethyl acetate; | Example 65 3-[3-(4-Chlorophenyl)-thioureido]-4-methoxy-N-phenyl-benzamide Prepared according to the procedure described for Example 60 using 3-amino-4-methoxy-N-phenyl-benzamide (0.243 g, 1.0 mmol) and 4-chlorophenyl isothiocyanate (0.174 g, 1.03 mmol). Trituration in hexanes/ethyl acetate (1:1) gave the product (0.362 g); m.p. 179-180 C. Calculated for C21H18ClN3O2S: C, 61.23; H, 4.40; N, 10.20. Found: C, 60.94; H, 4.23; N, 10.03. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Part 3. Preparation of 1-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-1H-imidazole-2-thiol; A mixture of 2-amino-1-(4-fluoro-phenyl)-ethanone hydrochloride (1 eq), 4-chlorophenyl isothiocyanate (1 eq) and sodium hydrogencarbonate (1.5 eq) in ethanol is heated at 90 C. for 2 hours. The solvent is removed under reduce pressure. The resulting residue is re-suspended in aqueous 1N sodium hydroxide and heated at 100 C. overnight. The hot mixture is filtered, cooled and carefully acidified with aqueous 6N HCl. The resulting mixture is filtered to give 1-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-1H-imidazole-2-thiol. | ||
A mixture of 2-amino-1-(4-fluoro-phenyl)-ethanone hydrochloride (1 eq), 4-chlorophenyl isothiocyanate (1 eq) and sodium hydrogencarbonate (1.5 eq) in ethanol is heated at 90 C. for 2 hours. The solvent is removed under reduce pressure. The resulting residue is re-suspended in aqueous 1N sodium hydroxide and heated at 100 C. overnight. The hot mixture is filtered, cooled and carefully acidified with aqueous 6N HCl. The resulting mixture is filtered to give 1-(4-chloro-phenyl)-5-(4-fluoro-phenyl)-1H-imidazole-2-thiol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | With montmorillonite K10 Clay; In acetonitrile; at 20℃; for 3h; | General procedure: A round bottom flask containing commercially available montmorillonite K10 (10 molpercent) was placed in an oven at 120-130°C for 30 minutes and then it was cooled to room temperature under nitrogen protection. To the activated montmorillonite K10 was added isothiocyanate (3.4 mmol) and <strong>[25475-67-6]3-aminoisoquinoline</strong> (3.4 mmol) followed by acetonitrile (2 mL) at room temperature. The resulting suspension was stirred at room temperature for 1-3 hour. When the reaction was completed (detected by TLC), ethyl acetate (30 mL) was added and the catalyst was filtered off to recover. The organic layer was washed with water (3×30 mL), and finally with half saturated brine, dried over anhydrous Na2SO4 and concentrated by rotary evaporator. Finally, the residue was purified by recrystallization from ethanol. |