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Chemical Structure| 21240-34-6 Chemical Structure| 21240-34-6

Structure of 21240-34-6

Chemical Structure| 21240-34-6

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Product Details of [ 21240-34-6 ]

CAS No. :21240-34-6
Formula : C15H10O3
M.W : 238.24
SMILES Code : O=C1OC(C2=CC=CC=C2)=C(C3=CC=CC=C3)O1
MDL No. :MFCD00005381

Safety of [ 21240-34-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 21240-34-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 21240-34-6 ]

[ 21240-34-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 21240-34-6 ]
  • [ 61477-39-2 ]
  • 3-[(1S)-3-hydroxy-1-methylpropyl]-4,5-diphenyloxazol-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
59% A mixture of (S)-3-Aminobutan-1-ol (4.25 mL, 42.0 mmol) and 4,5-diphenyl-1,3- dioxol-2-one (10.0 g, 42.0 mmol) in DMF (125 mL) was allowed to stir at RT overnight. The reaction was diluted with H2O and extracted with EtOAc (X5), and the combined organic layers washed (H2O X5, brine), dried (Na2SO4) and concentrated in vacuo. The residue was treated with TFA (39.0 mL, 504 mmol) and the solution was allowed to stir for 2 hours. The solution was concentrated and the residue taken up in MeOH and treated with K2CO3(11.9 mL, 210 mmol) and the mixture was allowed to stir for 1 hour. The mixture was concentrated and the residue was diluted with H2O and extracted with EtOAc (X3), and the combined organic layers washed (H2O X2, brine), dried (Na2SO4) and concentrated in vacuo. The residue was purified by column chromatography (0 to 100percent EtOAc in hexanes) to give a colorless solid (7.60 g, 59percent).
 

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